Methods for the treatment of erectile dysfunction using fispemifene

Abstract

A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.

1 . A method of raising testosterone, luteinizing hormone, and follicle-stimulating hormone in a subject suffering from erectile dysfunction and secondary hypogonadism comprising administering an amount of fispemifene sufficient to raise levels of testosterone, luteinizing hormone, and follicle-stimulating hormone. 
     
     
         2 . The method of  claim 1  wherein the amount of fispemifene is effective to treat the erectile dysfunction. 
     
     
         3 . The method of  claim 1  further comprising administering a therapeutically effective amount of a PDE-5 inhibitor to treat the erectile dysfunction.