Topical compositions

Abstract

Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.

That which is claimed is: 
     
         1 . An anhydrous topical composition comprising at least one viscosity increasing agent, at least one organic solvent and at least one humectant. 
     
     
         2 . The anhydrous topical composition of  claim 1 , wherein
 the at least one viscosity increasing agent is present in the composition at a concentration in a range of 0.5 to 30 weight percent;   the at least one organic solvent is present in the composition at a concentration in a range of 50 to 90 weight percent; and   the at least one humectant is present in the composition at a concentration in a range of 2 to 20 weight percent.   
     
     
         3 . The anhydrous topical composition of  claim 2 , wherein the at least one viscosity increasing agent comprises hydroxypropylcellulose; the at least one organic solvent comprises ethanol and the at least one humectant comprises hexylene glycol. 
     
     
         4 . The anhydrous topical composition of  claim 1 , further comprising at least one water repellant. 
     
     
         5 . The anhydrous topical composition of  claim 4 , wherein
 the at least one viscosity increasing agent is present in the composition at a concentration in a range of 0.5 to 30 weight percent;   the at least one organic solvent is present in the composition at a concentration in a range of 50 to 90 weight percent;   the at least one humectant is present in the composition at a concentration in a range of 2 to 20 weight percent; and   the at least one water repellent is present in the composition at a concentration in a range of 0.5 to 15 weight percent.   
     
     
         6 . The anhydrous topical composition of  claim 5 , wherein the at least one viscosity increasing agent comprises hydroxypropylcellulose; the at least one organic solvent comprises ethanol and the at least one humectant comprises hexylene glycol; and the at least one water repellent comprises cyclomethicone. 
     
     
         7 . The anhydrous topical composition of  claim 1 , further comprising a water reactive active pharmaceutical ingredient (API). 
     
     
         8 . The anhydrous topical composition of  claim 7 , wherein the water reactive API releases nitric oxide (NO) upon contact with water. 
     
     
         9 . The anhydrous topical composition of  claim 8 , wherein the water reactive API comprises a diazeniumdiolate functional group. 
     
     
         10 . The anhydrous topical composition of  claim 9 , wherein the water reactive API comprises a NO-releasing co-condensed silica. 
     
     
         11 . The anhydrous topical composition of  claim 10 , wherein the co-condensed silica has a mean particle size of less than 10 μm. 
     
     
         12 . A packaged nitric oxide-releasing topical gel having a shelf life of at least four weeks. 
     
     
         13 . The packaged nitric oxide-releasing topical gel of  claim 12 , wherein the shelf life is under refrigerated conditions. 
     
     
         14 . The packaged nitric oxide-releasing topical gel according to  claim 12 , wherein the shelf life is at least 52 weeks. 
     
     
         15 . The packaged nitric oxide releasing topical gel according to  claim 12 , wherein the shelf life is a predicted shelf life. 
     
     
         16 . A packaged nitric oxide-releasing topical gel having a useful life of at least 30 days. 
     
     
         17 . The packaged nitric oxide-releasing topical gel according to  claim 16 , wherein the useful shelf life is a predicted useful shelf life. 
     
     
         18 . An anhydrous topical composition comprising:
 hydroxypropyl cellulose present in the composition at a concentration in a range of 0.1 to 15 weight percent;   ethyl alcohol or isopropyl alcohol present in the composition at a concentration in a range of 45 to 95 weight percent;   hexylene glycol present in the composition at a concentration in a range of 1 to 20 weight percent;   cyclomethicone present in the composition at a concentration in a range of 0.5 to 15 weight percent; and   a diazeniumdiolated co-condensed silica particle at a concentration in a range of 0.1 to 40 weight percent.   
     
     
         19 . The anhydrous topical composition of any of  claim 1  or  18 , wherein the anhydrous topical composition is non-drying and/or non-irritating. 
     
     
         20 . A method of treating a dermatological condition comprising applying the anhydrous topical composition of any of  claim 1 - 11  or  18 - 19  to the skin of a patient to treat the dermatological condition. 
     
     
         21 . The method of  claim 20 , wherein the dermatological condition comprises acne.