Composition for preventing or treating gastritis or peptic ulcer

Abstract

The present invention relates to a pharmaceutical or food composition comprising Cinnamomum cassia pretreated extract exhibiting an excellently enhanced pharmacological effect than Cinnamomum cassia extract prepared by a conventional common extraction method of Cinnamomum cassia and extract prepared with Cinnamomum cassia single herb medicine, or a method for preventing, improving or treating gastritis or peptic ulcer using the composition. In addition, the present invention relates to a preparation method of Cinnamomum cassia pretreated extract which is characterized by pretreating Cinnamomum cassia with a non-polar solvent and extracting it with a polar solvent.

1 . A pharmaceutical composition for preventing or treating gastritis or peptic ulcer comprising non-polar solvent pretreatment and polar solvent extract of  Cinnamomum cassia.    
     
     
         2 . The pharmaceutical composition according to  claim 1 , wherein the peptic ulcer is stomach ulcer or duodenal ulcer. 
     
     
         3 . The pharmaceutical composition according to  claim 1 , wherein the non-polar solvent is ethyl acetate. 
     
     
         4 . The pharmaceutical composition according to  claim 1 , wherein the polar solvent is water. 
     
     
         5 . The pharmaceutical composition according to  claim 1 , which is administered once or several times as divided, wherein the pharmaceutical composition is characterized by comprising the extract so that the daily dose of the  Cinnamomum cassia  pretreated extract is 9.7 to 2,919 mg. 
     
     
         6 . The pharmaceutical composition according to  claim 1 , wherein the yield of the  Cinnamomum cassia  pretreated extract is 15 to 20→1 (meaning that 1 Kg of the final extraction dry ex is obtained when adding 15 to 20 Kg of crude herb medicine). 
     
     
         7 . A food composition for preventing or improving gastritis or peptic ulcer comprising non-polar solvent pretreatment and polar solvent extract of  Cinnamomum cassia.    
     
     
         8 . The food composition according to  claim 7 , wherein the peptic ulcer is stomach ulcer or duodenal ulcer. 
     
     
         9 . The food composition according to  claim 7 , wherein the non-polar solvent is ethyl acetate. 
     
     
         10 . The food composition according to  claim 7 , wherein the polar solvent is water. 
     
     
         11 . The food composition according to  claim 7 , which is administered once or several times as divided, wherein the  Cinnamomum cassia  pretreated extract is characterized by comprising the extract so that the daily dose of the  Cinnamomum cassia  pretreated extract is 9.7 to 2,919 mg. 
     
     
         12 . The food composition according to  claim 1 , wherein the composition is health functional food, health supplementary food or functional food. 
     
     
         13 . A preparation method of  Cinnamomum cassia  non-polar solvent pretreatment and polar solvent extract comprising
 a) a step of pretreating  Cinnamomum cassia  by immersing into a non-polar solvent;   b) a step of removing the non-polar solvent in the step a); and   c) a step of extracting  Cinnamomum cassia  obtained in the step b) with a polar solvent.   
     
     
         14 . The preparation method according to  claim 13 , wherein the non-polar solvent in the step a) is ethyl acetate. 
     
     
         15 . The preparation method according to  claim 13 , wherein the step a) is performed by immersing  Cinnamomum cassia  into a non-polar solvent having a weight of 1 to 3 times compared to  Cinnamomum cassia  herb medicine and stirring at 20 to 35° C. for 30 minutes to 3 hours. 
     
     
         16 . The preparation method according to  claim 13 , wherein the polar solvent used in the step c) is water. 
     
     
         17 . The preparation method according to  claim 13 , wherein the step c) is performed by extracting  Cinnamomum cassia  obtained in the step b) for 80 to 100° C. for 2 hours to 6 hours using a polar solvent of 6 times to 10 times compared to  Cinnamomum cassia  herb medicine. 
     
     
         18 . The preparation method according to  claim 13 , wherein the dry yield of the extract prepared in the step c) is 15˜20→1 (meaning that 1 Kg of the final extraction dry ex is obtained when adding 15 to 20 Kg of crude herb medicine). 
     
     
         19 . A method for preventing, improving or treating gastritis or peptic ulcer, comprising a step of administering a composition comprising non-polar solvent pretreatment and polar solvent extract of  Cinnamomum cassia.