Microneedle Device

Abstract

The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

1 - 9 . (canceled) 
     
     
         10 . A method for producing a microneedle device comprising the steps of:
 providing a microneedle array comprising a substrate and a microneedle;   mixing a physiologically active substance, arginine, and glycerin to obtain a coating composition;   coating the microneedle with the coating composition; and   drying the coating composition to form a coating layer on the microneedle.   
     
     
         11 . The method according to  claim 10 , wherein the coating composition further contains an acid selected from the group consisting of citric acid, phosphoric acid, boric acid, tartaric acid, and lactic acid. 
     
     
         12 . The method according to  claim 10 , wherein the drying is performed until, in the coating layer, the mass of arginine reaches 0.06 to 0.85-fold of the mass of the physiologically active substance and the mass of glycerin reaches 40% or less relative to the mass of the whole coating layer. 
     
     
         13 . The method according to  claim 11 , wherein the drying is performed until, in the coating layer, the mass of arginine reaches 0.06 to 0.85-fold of the mass of the physiologically active substance and the mass of glycerin reaches 40% or less relative to the mass of the whole coating layer.