US2020071337A1PendingUtilityA1

Antiviral compounds

72
Assignee: GILEAD PHARMASSET LLCPriority: Nov 16, 2011Filed: Apr 8, 2019Published: Mar 5, 2020
Est. expiryNov 16, 2031(~5.3 yrs left)· nominal 20-yr term from priority
Inventors:Elizabeth M. BaconJeromy J. CottellAshley Anne KatanaDarryl KatoEvan S. KrygowskiJohn O. LinkJames G. TaylorChinh Viet TranTeresa Alejandra Trejo MartinZheng-Yu YangSheila Zipfel
A61P 43/00A61P 31/14A61P 31/12A61P 1/16C07D 405/12A61K 38/07A61K 31/7064A61K 38/06C07D 491/052A61K 45/06A61K 31/7056A61K 2300/00A61K 31/7072A61K 38/21A61K 47/60A61K 31/4188C07F 5/025Y10S514/894
72
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Claims

Abstract

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Claims

exact text as granted — not AI-modified
1 - 38 . (canceled) 
     
     
         39 . A compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         40 . A process for preparing a compound of formula: 
       
         
           
           
               
               
           
         
         comprising contacting a compound of formula: 
       
       
         
           
           
               
               
           
         
         with a solution comprising HCl, followed by (R)-2-(methoxycarbonylamino)-2-phenylacetic acid under conditions sufficient to provide the compound of formula: 
       
       
         
           
           
               
               
           
         
       
     
     
         41 . A compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         42 . A process for preparing a compound of formula: 
       
         
           
           
               
               
           
         
         comprising contacting a compound of formula: 
       
       
         
           
           
               
               
           
         
         with a solution comprising HCl, followed by (R)-2-(methoxycarbonylamino)-2-phenylacetic acid under conditions sufficient to provide the compound of formula: 
       
       
         
           
           
               
               
           
         
       
     
     
         43 . The process of  claim 42 , wherein the compound of formula: 
       
         
           
           
               
               
           
         
       
       is prepared a process comprising contacting a compound of formula: 
       
         
           
           
               
               
           
         
       
       with tert-butyl (2S,4S)-2-(5-iodo-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate under conditions sufficient to provide the compound of formula: 
       
         
           
           
               
               
           
         
       
     
     
         44 . The process of  claim 43 , wherein the conditions comprise a palladium catalyst. 
     
     
         45 . The process of  claim 43 , wherein the compound of formula: 
       
         
           
           
               
               
           
         
         is prepared a process comprising: 
         a) oxidizing a compound of formula: 
       
       
         
           
           
               
               
           
         
         to provide a compound of formula: 
       
       
         
           
           
               
               
           
         
         b) contacting the compound of formula 
       
       
         
           
           
               
               
           
         
         with a solution comprising HCl, followed by (methoxycarbonyl)-L-valine under conditions sufficient to provide a compound of formula: 
       
       
         
           
           
               
               
           
         
          and 
         c) contacting the compound of formula: 
       
       
         
           
           
               
               
           
         
         with bis(pinacolato)diboron under conditions sufficient to provide the compound of formula: 
       
       
         
           
           
               
               
           
         
       
     
     
         46 . A compound of formula:

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