US2020078328A1PendingUtilityA1

Medicaments for slowing parkinson's disease

59
Assignee: BIAL PORTELA & CA SAPriority: Nov 28, 2014Filed: Jul 17, 2019Published: Mar 12, 2020
Est. expiryNov 28, 2034(~8.4 yrs left)· nominal 20-yr term from priority
Inventors:Patricio Manuel Vieira Araujo Soares Da SilvaJose Francisco Da Costa De Pinho Rocha
A61P 43/00A61P 25/16A61K 31/165A61K 31/198A61K 45/06A61K 2300/00A61K 31/4439A61K 31/00
59
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Claims

Abstract

Opicapone, levodopa and an AADC inhibitor are described for use in slowing the progression of Parkinson's Disease.

Claims

exact text as granted — not AI-modified
1 - 6 . (canceled) 
     
     
         7 . A method of slowing progression of Parkinson's Disease which method comprises administering to a patient not previously treated for Parkinson's Disease an effective amount of:
 (i) levodopa;   (ii) an AADC inhibitor; and   (iii) opicapone.   
     
     
         8 - 9 . (canceled) 
     
     
         10 . The method of  claim 7 , wherein the slowing of the progression of Parkinson's Disease involves a delay in the progression of Parkinson's Disease by a period of at least one month. 
     
     
         11 . (canceled) 
     
     
         12 . The method of  claim 7 , wherein opicapone is administered once a day and levodopa is administered from 2 to 10 times a day. 
     
     
         13 . A method as claimed in  claim 12 , wherein levodopa is administered 3, 4, 5 or 6 times a day. 
     
     
         14 . The method of  claim 7 , wherein the dose of opicapone is 25 mg to 100 mg. 
     
     
         15 . The method of  claim 7 , wherein the AADC inhibitor is carbidopa or benserazide. 
     
     
         16 . The method of  claim 7 , wherein the levodopa is present in a unit dose of from 50 mg to 250 mg. 
     
     
         17 . The method of  claim 7 , wherein the levodopa is present in a tablet at 100 mg. 
     
     
         18 . The method of  claim 7 , wherein the AADC inhibitor is carbidopa or benserazide, wherein the levodopa and the AADC inhibitor are present in a single dosage unit. 
     
     
         19 . The method of  claim 18 , wherein the single dosage unit is a tablet comprising 100 mg levodopa and 25 mg carbidopa for use 3, 4, 5 or 6 times a day and opicapone 50 mg for use once a day. 
     
     
         20 . (canceled) 
     
     
         21 . The method of  claim 7 , wherein the patient benefits by more than 0.25 hr in OFF period. 
     
     
         22 . A method of delaying progression of Parkinson's Disease in patients treated with an effective dose of levodopa and an AADC inhibitor which comprises administering an effective dose of opicapone to said patient, wherein the patient has not been previously treated for Parkinson's disease. 
     
     
         23 . (canceled) 
     
     
         24 . The method of  claim 22 , wherein opicapone is administered once a day, wherein the dose of opicapone is 25 mg to 100 mg. 
     
     
         25 . The method of  claim 24 , wherein the dose of opicapone is 50 mg. 
     
     
         26 . The method of  claim 22 , wherein levodopa is administered 3, 4, 5 or 6 times a day, wherein levodopa is present in a unit dose of from 50 mg to 250 mg. 
     
     
         27 . The method of  claim 22 , wherein the AADC is carbidopa or benserazide in a ratio of 1:4 with levodopa. 
     
     
         28 . The method of  claim 26 , wherein levodopa is used at 100 mg and carbidopa at 25 mg. 
     
     
         29 - 41 . (canceled)

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