US2020085753A1PendingUtilityA1

Microparticles, methods for their preparation and use

62
Assignee: HARVARD COLLEGEPriority: Nov 8, 2013Filed: Sep 19, 2019Published: Mar 19, 2020
Est. expiryNov 8, 2033(~7.3 yrs left)· nominal 20-yr term from priority
Inventors:David A. WeitzStefanie UtechEsther AmstadRaluca OstafeAngelo S. MaoDavid J. MooneyConnie Chang WilkingHuanan WangRadivoje Prodanovich
A61K 9/5036A61K 35/00A61K 9/5089A61K 9/1652
62
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Claims

Abstract

The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.

Claims

exact text as granted — not AI-modified
1 - 42 . (canceled) 
     
     
         43 . An article, comprising:
 a tissue scaffold, comprising a plurality of microparticles, the microparticles comprising a core and a shell,   a first cell type in the core, and   a second cell type in the shell.   
     
     
         44 . The article of  claim 43 , wherein the microparticles comprise a crosslinked gel. 
     
     
         45 . The article of  claim 43 , wherein the microparticles comprise a Ca 2+ -crosslinked alginate gel. 
     
     
         46 . The article of  claim 43 , wherein the microparticles have a coefficient of variation in size distribution of from about 0.03 to about 0.05. 
     
     
         47 . The article of  claim 43 , wherein the microparticles comprise an alginate gel or a alginate derivative thereof. 
     
     
         48 . The article of  claim 43 , wherein the first cell type grows in three dimensions within the microparticles. 
     
     
         49 . The article of  claim 43 , wherein the second cell type grows in three dimensions within the microparticles. 
     
     
         50 . The article of  claim 43 , wherein the microparticles further comprise a virus. 
     
     
         51 . The article of  claim 43 , wherein the microparticles further comprise a protein. 
     
     
         52 . The article of  claim 43 , wherein the first cell type at least partially protrudes into the shell. 
     
     
         53 . The article of  claim 43 , wherein the second cell type at least partially protrudes into the core. 
     
     
         54 . The article of  claim 43 , wherein the first cell type at least partially protrudes to an exterior of the microparticles. 
     
     
         55 . The article of  claim 43 , wherein the second cell types at least partially protrudes to an exterior of the microparticles. 
     
     
         54 . The article of  claim 43 , wherein the microparticles further comprise pores. 
     
     
         55 . The article of  claim 43 , wherein the first cell type and the second cell type are present in different concentrations.

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