Depot formulations

Abstract

Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.

1 . A formulation comprising:
 (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;   (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer; and   (iii) one or more solvents that have a solvent capacity,   wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and   wherein   (a) R satisfies the following: 0.55≤R≤ about 0.95;   (b) when R satisfies the following: 0.55≤R≤0.85, the solvent capacity of the one or more solvents is greater than or equal to about 20%; and   (c) when R satisfies the following: greater than 0.85 to about 0.95, the solvent capacity of the one or more solvents is greater than or equal to about 10%.   
     
     
         2 - 40 . (canceled)