US2020102295A1PendingUtilityA1
Nitrocatechol derivatives as comt inhibitors
Est. expiryJul 26, 2025(expired)· nominal 20-yr term from priority
Inventors:David Alexander LearmonthLaszlo Erno KissPedro Nuno Leal PalmaHumberto Dos Santos FerreiraPatricio Manuel Vieira Araujo Soares Da Silva
C07D 413/06C07D 215/60A61P 9/12A61K 31/4412C07D 413/14C07D 271/06C07D 413/12A61K 31/4425A61P 1/00C07D 417/04A61P 27/02A61P 43/00C07D 401/04C07D 413/04C07D 213/89C07D 271/107A61P 25/14A61K 31/4245A61P 25/00A61P 25/02A61P 1/04A61P 7/10C07D 405/04A61P 25/16A61K 31/421
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Claims
Abstract
New compounds of formula I are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
Claims
exact text as granted — not AI-modified1 - 24 . (canceled)
25 . A compound according to formula IIA, IIB or IIC,
wherein R 4 , R 5 , R 6 and R 7 independently from each other represent hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -thioalkyl, C 1 -C 6 -alkoxy, C 6 -C 12 -aryloxy, a C 6 -C 12 -thioaryl group, C 1 -C 6 -alkanoyl, a C 7 -C 13 -aroyl group, amino, C 1 -C 6 -alkylamino, C 1 -C 6 -dialkylamino, C 3 -C 12 -cycloalkylamino, C 3 -C 12 -heterocycloalkylamino, C 1 -C 6 -alkylsulphonyl, C 6 -C 12 -arylsulphonyl, halogen, C 1 -C 6 -halo alkyl, trifluoromethyl, cyano, nitro or a heteroaryl group; or where two or more of residues R 4 , R 5 , R 6 and R 7 taken together represent aliphatic or heteroaliphatic rings or aromatic or heteroaromatic rings.
26 . The compound of claim 25 , wherein R 4 , R 5 , R 6 and R 7 independently from each other represent C 1 -C 6 -alkyl or halogen.
27 . The compound of claim 25 , wherein R 4 is Cl; R 5 is CH 3 ; R 6 is Cl; and R 7 is CH 3 .
28 . A compound according to formula VA, VB, or VC,
wherein R 4 , R 5 , R 6 and R 7 independently from each other represent hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -thioalkyl, C 1 -C 6 -alkoxy, C 6 -C 12 -aryloxy, a C 6 -C 12 -thioaryl group, C 1 -C 6 -alkanoyl, a C 7 -C 13 -aroyl group, amino, C 1 -C 6 -alkylamino, C 1 -C 6 -dialkylamino, C 3 -C 12 -cycloalkylamino, C 3 -C 12 -heterocycloalkylamino, C 1 -C 6 -alkylsulphonyl, C 6 -C 12 -arylsulphonyl, halogen, C 1 -C 6 -haloalkyl, trifluoromethyl, cyano, nitro or a heteroaryl group; or where two or more of residues R 4 , R 5 , R 6 and R 7 taken together represent aliphatic or heteroaliphatic rings or aromatic or heteroaromatic rings.
29 . The compound of claim 28 , wherein R 4 , R 5 , R 6 and R 7 independently from each other represent C 1 -C 6 -alkyl or halogen.
30 . The compound of claim 28 , wherein R 4 is Cl; R 5 is CH 3 ; R 6 is Cl; and R 7 is CH 3 .
31 . A compound according to formula VILA, VIIB or VIIC,
wherein R 4 , R 5 , R 6 and R 7 independently from each other represent hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -thioalkyl, C 1 -C 6 -alkoxy, C 6 -C 12 -aryloxy, a C 6 -C 12 -thioaryl group, C 1 -C 6 -alkanoyl, a C 7 -C 13 -aroyl group, amino, C 1 -C 6 -alkylamino, C 1 -C 6 -dialkylamino, C 3 -C 12 -Cycloalkylamino, C 3 -C 12 -heterocycloalkylamino, C 1 -C 6 -alkylsulphonyl, C 6 -C 12 -arylsulphonyl, halogen, C 1 -C 6 -haloalkyl, trifluoromethyl, cyano, nitro or a heteroaryl group; or where two or more of residues R 4 , R 5 , R 6 and R 7 taken together represent aliphatic or heteroaliphatic rings or aromatic or heteroaromatic rings.
32 . The compound of claim 31 , wherein R 4 , R 5 , R 6 and R 7 independently from each other represent C 1 -C 6 -alkyl or halogen.
33 . The compound of claim 31 , wherein R 4 is Cl; R 5 is CH 3 ; R 6 is Cl; and R 7 is CH 3 .Join the waitlist — get patent alerts
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