US2020129537A1PendingUtilityA1

Compositions comprising s-adenosylmethionine and a gallic acid ester

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Assignee: MSI METHYLATION SCIENCES INCPriority: Oct 17, 2012Filed: Dec 26, 2019Published: Apr 30, 2020
Est. expiryOct 17, 2032(~6.2 yrs left)· nominal 20-yr term from priority
Inventors:Dechi GuanI. David Macdonald
A61P 11/06A61P 29/00A61P 15/00A61K 9/28A61K 9/2054A61K 31/7076A61K 9/4866A61P 1/16A61P 35/00A61K 47/14A61P 1/04A61P 31/18A61P 11/02A61P 19/02A61P 39/06A61P 37/00A61K 31/235A61K 9/0053A61K 9/2059A61P 25/32A61P 25/18A61P 25/00A61P 25/28A61P 17/00A61P 25/22A61P 17/18A61P 37/06A61P 37/08A61P 1/00A61P 9/10A61P 31/20A61P 31/14A61P 25/24A61P 25/16A61K 31/353A61P 9/00A61P 43/00A61P 25/04
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Claims

Abstract

Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a disease or disorder comprising administering a composition comprising exogenous S-adenosylmethionine and at least one gallic acid ester to a patient in need thereof.

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