Compositions and methods for treating conditions related to adrenocortical activity and/or excessive steroid production

Abstract

Provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production. In particular, provided herein are methods for treating subjects having conditions related to adrenocortical activity and/or excessive steroid production through administration of at least one of the following agents: 1) an agent capable of inhibiting cholesterol efflux related to ABCA1 and/or ABCG1; 2) an agent capable of inhibiting MDR1 related cortisol secretion and/or MDR1 P-glycoprotein multiple drug transporter activity; and 3) an agent capable of inhibiting mitochondrial activity.

What is claimed is: 
     
         1 . A method of treating, ameliorating, or preventing a condition related to adrenocortical activity and/or excessive steroid production comprising co-administering to said patient a therapeutically effective amount of two or more agents selected from
 1) an agent capable of inhibiting cholesterol efflux related to ABCA1 and/or ABCG1;   2) an agent capable of inhibiting MDR1 related cortisol secretion and/or MDR1 P-glycoprotein multiple drug transporter activity; and   3) an agent capable of inhibiting mitochondrial activity.