Composition For Enhancing Protein Strength

Abstract

A composition for enhancing protein strength according to the present invention contains an aminosilane compound capable of covalent binding with a protein of hair, scalp, skin, nails, leather, or textile, so that the protein and the amino silane compound form a covalent bond, and thus the composition can improve the protein strength enhancement effect and maximize the semi-permanent protein strength enhancement effect.

1 . A composition for enhancing protein strength, comprising:
 an aminosilane compound; and   a reaction mediator.   
     
     
         2 . The composition according to  claim 1 , wherein the aminosilane compound is selected from the group consisting of the compounds represented by Formulas 1 to 3 below: 
       
         
           
           
               
               
           
         
         wherein in Formulas 1 to 3, R 1  is each independently hydrogen; or a linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms or a benzene ring hydrocarbon, which includes one or more double bonds in a part of the molecule, or is substituted with one or more atoms selected from the group consisting of O, N, S, P and Si or substituted in an anionic, cationic or amphoteric form, or includes a structure to which a metal ion is bonded in a salt form; and R 2  is each independently a linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms or a benzene ring hydrocarbon, which includes one or more double bonds in a part of the molecule, or is substituted with one or more atoms selected from the group consisting of O, N, S, P and Si or substituted in an anionic, cationic or amphoteric form, or includes a structure to which a metal ion is bonded in a salt form and in which at least one primary or secondary amine is included at an end of the molecular structure. 
       
     
     
         3 . The composition according to  claim 1 , wherein the aminosilane compound is one or more selected from the group consisting of 3-aminopropyltriethoxysilane, bis[(3-triethoxysilyl)propyl]amine, 3-aminopropyltrimethoxysilane, 4-aminobutyltriethoxysilane, bis[(3-trimethoxysilyl)propyl]amine, 3-aminopropylmethyldiethoxysilane, 3-aminopropyldimethylethoxysilane, 3-aminopropylmethyldimethoxysilane, aminoethylaminopropyltrimethoxysilane, aminoethylaminopropyltriethoxysilane, aminoethylaminopropylmethyldimethoxysilane, diethylenetriaminopropylmethyldimethoxysilane, piperazinylpropylmethyldimethoxysilane, (n-phenylamino)methyltrimethoxysilane, (n-phenylamino)methyltriethoxysilane, 3-(n-phenylamino)propyltrimethoxysilane, n-(n-butyl)-3-aminopropyltrimethoxysilane, 4-aminobutyltriethoxysilane, m-aminophenyltrimethoxysilane, p-aminophenyltrimethoxysilane, aminophenyltrimethoxysilane, m-aminophenyltriethoxysilane, p-aminophenyltriethoxysilane, aminophenyltriethoxysilane, 3-aminopropyltris(methoxyethoxy-ethoxy)silane, 11-aminoundecyltriethoxysilane, 3-(m-aminophenoxy(propyltrimethoxy-silane), aminopropylsilanetriol, 3-aminopropylmethyldiethoxysilane, 3-aminopropyldiisopropylethoxy-silane, 3-aminopropyldimethylethoxysilane, n-(2-aminoethyl)-3-aminopropyltri-methoxysilane, n-(2-aminoethyl)-3-aminopropyltri-ethoxysilane, n-(6-aminohexyl)aminomethyl-triethoxysilane, n-(6-aminohexyl)aminopropyl-trimethoxysilane, n-(2-aminoethyl)-11-aminoundecyl-trimethoxysilane, (aminoethylaminomethyl)phenethyl-trimethoxysilane, n-3-[(amino(polypropylenoxy)]amino-propyltrimethoxysilane, n-(2-aminoethyl)-3-aminopropyl-silanetriol, n-(2-aminoethyl)-3-aminopropylmethyl-dimethoxysilane, n-(2-aminoethyl)-3-aminoisobutyl-methyldimethoxysilane, (aminoethylamino)-3-isobutyldi-methylmethoxysilane, (3-trimethoxysilylpropyl)diethylene-triamine, n-butylaminopropyltrimethoxy-silane, n-ethylaminoisobutyltrimethoxy-silane, n-methylaminopropyltrimethoxy-silane, n-phenylaminopropyltrimethoxy-silane, 3-(n-allylamino)propyltrimethoxy-silane, (cyclohexylaminomethyl)tri-ethoxysilane, n-cyclohexylaminopropyltrimeth-oxysilane, n-ethylaminoisobutylmethyl-diethoxysilane, (phenylaminomethyl)methyl-dimethoxysilane, n-phenylaminomethyltriethoxysilane, n-methylaminopropylmethyl-dimethoxysilane, 3-(n-styrylmethyl-2-aminoethylamino)-propyltrimethoxysilane hydrochloride, n-(trimethoxysilylpropyl)isothio-uronium chloride, bis[(3-trimethoxysilyl)propyl]-ethylenediamine, bis[(3-trimethoxysilyl)propyl]-ethylenediamine, bis[3-(triethoxysilyl)propyl]urea, bis(trimethoxysilylpropyl)urea, bis(methyldiethoxysilylpropyl)amine, ureidopropyltriethoxysilane, acetamidopropyltrimethoxysilane, n-[5-(trimethoxysilyl)-2-aza-1-oxo-pentyl]caprolactam and ureidopropyltrimethoxysilane. 
     
     
         4 . The composition according to  claim 1 , wherein the reaction mediator is one or more selected from the group consisting of a carbodiimide-based compound, a dihydroxyquinoline-based compound, an aminium-based compound, a phosphonium-based compound and an enzyme. 
     
     
         5 . The composition according to  claim 4 , wherein the carbodiimidie-based compound is a compound having at least one methane diimine (—N═C═N—) in the molecule. 
     
     
         6 . The composition according to  claim 4 , wherein the carbodiimidie-based compound is a compound represented by Formula 4 below: 
       
         
           
           
               
               
           
         
         wherein in Formula 4, A is a monomer which has one or more structures selected from the group consisting of 
       
       
         
           
           
               
               
           
         
         and includes isocyanate (*) groups at both ends of a repeat unit, wherein R is each independently hydrogen; or a linear, branched or cyclic hydrocarbon having 1 to 500 carbon atoms or a benzene ring hydrocarbon, which includes one or more double bonds in a part of the molecule, or is substituted with one or more atoms selected from the group consisting of O, N, S, P and Si or substituted in an anionic, cationic or amphoteric form, or includes a structure to which a metal ion is bonded in a salt form; and m is an integer of 1 to 100. 
       
     
     
         7 . The composition according to  claim 4 , wherein the dihydroxyquinoline-based compound is a compound represented by Formula 5 below: 
       
         
           
           
               
               
           
         
         Wherein in Formula 5, R 1  is one selected from the group consisting of aqueous non-ionic polymers; bead- and resin-type polymer resins; and silica beads, and R 2  and R 3  are each independently a linear or branched saturated alkyl group having 1 to 10 carbon atoms; or an unsaturated alkyl group. 
       
     
     
         8 . The composition according to  claim 7 , wherein the aqueous non-ionic polymer is one or more polymers selected from the group consisting of polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyethylene oxide (PEO), polyacrylonitrile (PAN), polyvinylpyrrolidone (PVP), polyisopropylacrylamide (PNIPPAm), a cellulose derivative, a starch derivative, dextran and guar gum, and has a molecular weight of less than 20,000 Da. 
     
     
         9 . The composition according to  claim 7 , wherein the bead- and resin-type polymer resin is a polymer prepared by polymerizing one or more monomers selected from the group consisting of styrene, ethylene, butadiene, acrylonitrile, methylstyrene, terephthalate, ethylene chloride, ketone ether, imide ether, sulfone ether, phthalamide, phenylene ether, phenylene oxide, phenylsulfide, sulfone, urethane, vinylidene fluoride and tetrafluoroethylene, and has a molecular weight of less than 20,000 Da. 
     
     
         10 . The composition according to  claim 7 , wherein the silica bead has a diameter of 100 nm to 1 mm. 
     
     
         11 . The composition according to  claim 4 , wherein the aminium-based compound is one or more selected from the group consisting of N-[(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate N-oxide, N-[(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium hexafluoroborate, 2-(3,4-(N-[(1H-benzotriazol-1-yl) (dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate N-oxide, 2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3,-tetramethyl uronium tetrafluoroborate, O-(3,4,-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3,-tetramethyluronium hexafluoroborate, O-(3,4,-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3,-tetramethyluronium hexafluorophosphate, 2-(2-oxo-1(2H)-pyridyl-1,1,3,3,-tetramethyluronium tetrafluoroborate, 2-(2-oxo-1(2H)-pyridyl-1,1,3,3-tetramethyluronium tetrafluorophosphate, 2-succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate), 2-succinimido-1,1,3,3-tetramethyluronium tetrafluorophosphate, N,N,N′,N′-bis(tetramethylene-O-pentafluorophenyluronium tetrafluoroborate, N,N,N′,N′-bis(tetramethylene-O-pentafluorophenyluronium hexafluorophosphate, N-[6-trifluoromethyl(1H-benzotriazol-1-yl) (dimethylamino)methylene]-N-methyl methanaminium tetrafluoroborate N-oxide, N-[6-trifluoromethyl(1H-benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate N-oxide, N-[(dimethylamino)-1H-1,2,3-triazolo[4,5,b]pyridin-1-yl]methylene]-N-methylmethanaminium hexafluorophosphate N-oxide, N-[(dimethylamino)-1H-1,2,3-triazolo [4,5-b]pyridin-1-ylmethylene]-N-methyl methanaminium tetrafluoroborate N-oxide, N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-sulfide, S-(1-oxido-1-pyridinyl)-1,1,3,3-tetramethylthiouronium hexafluorophosphate, O-[cyano(ethoxycarbonyl)methyleneamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate, O-[cyano(ethoxycarbonyl) methylene amino]-N,N,N′,N′-tetramethyluronium hexafluorophosphate, O-[(dicyano methylidene)-amino]-1,1,3,3-tetramethyluronium hexafluorophosphate, O-[(dimethoxycarbonylmethylidene)-amino]-1,1,3,3-tetramethyluronium hexafluorophosphate, N-[(cyano(pyridin-2-yl)methylene aminooxy) (dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate, 2-(5-norbornene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium tetrafluoroborate, 2-phthalimido-1,1,3,3-tetramethyluronium tetrafluoroborate, bis(tetra methylene)chloroformamidinium hexafluorophosphate, (1H-benzotriazol-1-yl)(1-pyrollidinylmethylene) pyrrolidinium hexafluorophosphate N-oxide, 1-(1-pyrrolidinyl-1H-1,2,3-triazolo [4,5-b]pyridin-1-ylmethylene) pyrrolidinium hexafluorophosphate N-oxide, O-(3,4-dihydro-4-oxo-1,2,3-benzo triazin-3-yl)-1,1,3,3-bis(tetramethylene)uranium hexafluorophosphate, O-(3,4-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl)-1,1,3,3-bis(tetramethylene) uranium hexafluorophosphate, N,N,N′,N′-bis(tetra methylene)-O-pentafluoro phenyluronium hexafluorphosphate, N,N,N′,N′-bis(tetramethylene)-S-pentafluorothiophenyluronium hexafluorphosphate, 1-(1-pyrrolidinyl-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene) pyrrolidinium hexafluorophosphate N-sulfide, N,N,N′,N′-bis(tetramethylene)-O-2-nitrophenyluronium hexafluorophosphate, N,N,N′,N′-bis(tetramethylene)-O-pentafluorophenyluronium hexafluorohosphate, O-(benzotriazol-1-yl)-1,1,3,3-bis(pentamethylene) hexafluorophosphate, O-(7-azabenzotriazol-1-yl)-1,1,3,3-bis(pentamethylene)-uronium hexafluorophosphate, 2-[2-oxo-1(2H)-pyridyl]-1,1,3,3-bis(pentamethylene) uronium tetrafluoroborate, 2-chloro-1,3-dimethylimidazolidinium hexafluorophosphate, O-(benzotriazol-1-yl)-1,3-dimethyl-1,3-dimethylene uronium hexafluorophosphate, O-(7-azabenzotriazol-1-yl)-1,3-dimethyl-1,3-dimethyleneuronium hexafluorophosphate, 2-chloro-1,3-dimethylpyrimidinium hexafluorophosphate, O-(benzotriazol-1-yl)-1,3-dimethyl-1,3-trimethyleneuronium hexafluorophosphate, O-(7-azabenzotriazol-1-yl)-1,3-dimethyl-1,3-trimethyleneuronium hexafluorophosphate, (7-benzotriazol-yl)-1,1,3-tri methyl-1-hexafluorophosphate, (7-azabenzotriazol-yl)-1,1,3-trimethyl-1-phenyluronium hexafluorophosphate, O-(1H-benzotriazol-1-yl)-1,1-dimethyl-3,3-tetramethylene uranium hexafluorophosphate, O-(1H-1,2,3-triazolo[4,5-b[pyridin-yl)-1,1-dimethyl-3,3-tetramethyleneuronium hexafluorophosphate, O-(1H-benzotriazol-1-yl)-1,1-dimethyl-3,3-pentamethylene uranium hexafluorophosphate, 6-chloro-1((dimethylamino)(morpholino)methylene)-1H-benzo triazolium hexafluorophosphate-3oxide, 3-((dimethylamino)-(morpholino)methylene)-1H-[1,2,3]triazolo[4,5-b]pyridinium hexafluorophosphate, 6-trifluoromethyl-1-((dimethylamino)-(morpholino)methylene)-1H-benzotriazoliumhexafluorophosphate-3-oxide, 1-((dimethylamino)-(morpholino)) oxypentafluorophenylmetheniminium hexafluorophosphate, 1-[(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino morpholinomethylene)]methanaminium hexafluorophosphate, 1-[(1-(dicyanomethyleneaminooxy) dimethylamino morpholinomethylene)]methanaminium hexafluorophosphate, 1-[(1,3-diethoxy-1,3-dioxopropan-2-ylideneaminooxy) dimethylaminomorpholinomethylene)]methanaminium hexafluorophosphate, N-[(cyano(pyridin-2-yl)methyleneaminooxy) (dimethylamino)methylene]-N-morpholinomethanaminiumhexafluorophosphate, 1-[(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylaminopyrrolodino methylene)]methanaminium hexafluorophosphate, 1-((dicyanomethyleneaminooxy) morpholinomethylene)pyrrolidinium hexafluorophosphate, 1-[(1,3-diethoxy-1,3-dioxopropan-2-yldeneaminooxy)-dimethylamino-pyrrolodinomethylene]]methanaminium hexafluorophosphate, 1-[(1-(cyano-2-ethoxy-2-oxoethylidene aminooxy)-dimethylamino-pyrrolodinomethylene)]methanaminium hexafluororphosphate, 1-((1-cyano-2-ethoxy-2-oxoethylideneaminooxy)(morpholino) methylene)pyrrolidinium hexafluorophosphate, benzotriazol-1-yloxy-N,N-dimethyl-methanaminium hexachloroantimonate, 5-(1H-benzotriazol-1-yloxy)-3,4-dihydro-1-methyl-2H-pyrrolium hexachloroantimonate, 5-(7-azabenzotriazol-1-yloxy)-3,4-dihydro-1-methyl-2H-pyrrolium hexachloroantimonate, 1-(1H-benzotriaol-1-yloxy)phenyl-methylene pyrrolidinium hexachloroantimonate, 5-(pentafluorophenyloxy)-3,4-dihydro-1-methyl-2H-pyrrolium hexachloroantimonate, 5-(succinimidyloxy)-3,4-dihydro-1-methyl-2H-pyrrolium hexachloroantimonate, 5-(3′,4′-dihydro-4′-oxo-1′,2′,3′-benzotriazin-3′-yloxy)-3,4-diydro-1-methyl-2H-pyrrolium hexachloroantimonate) and a derivative thereof. 
     
     
         12 . The composition according to  claim 4 , wherein the phosphonium-based compound is a compound having one or more phosphonium salts in the molecule. 
     
     
         13 . The composition according to  claim 4 , wherein the phosphonium-based compound is one or more selected from the group consisting of benzotriazol-1-yloxytris (dimethylamino) phosphonium hexafluorophosphate, bromotris (dimethylamino) phosphonium hexafluorophosphate, chlorotri (pyrrolidino) phosphonium hexafluorophosphate, bromotri (pyrrolidino) phosphonium hexafluorophosphate, chloro-tris(dimethylamino) phosphonium hexafluorophosphate, benzotriazol-1-yloxytri (pyrrolidino) phosphonium hexafluorophosphate, [(7-azabenzotriazol-1-yl)oxy]tris-(dimethylamino) phosphonium hexafluorophosphate, [(7-azabenzotriazol-1-yl)oxy]tris-(pyrrolidino) phosphonium hexaflurophosphate, O-[(cyano-(ethoxycarbonyl)methyliden)-amino]-yloxytripyrrolidino phosphonium hexafluorophosphate, └(6-nitrobenzotriazol-yl)oxy┘tris-(pyrrolidino) phosphonium hexafluorophosphate, [(6-trifluoromethyl)benzotriazol-1-yl]oxy-tris(pyrrolidino)phosphonium hexafluorophosphate, [4-nitro-6-(trifluoromethyl)benzotriazol-1-yl]oxy]tris(pyrrolidino) phosphonium hexafluorophosphate, (6-chloro-benzotriazol-1-yloxy)tris (pyrrolidino)-phosphonium hexafluorophosphate, N′,N′,N′,N′-bis(tetramethylene)-O-pentafluoro phenyluronium hexafluorophosphate, (pyridyl-2-thio)tris (pyrrolidino)-phosphonium hexafluorophosphate, [(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)oxy]tris-(pyrrolidino)phosphonium hexafluorophosphate, [(3,4-dihydro-4-oxo-5-azabenzo-1,2,3-triazin-3-yl]tris-(pyrrolidino) phosphonium hexafluorophosphate and a derivative thereof. 
     
     
         14 . The composition according to  claim 4 , wherein the enzyme is transglutaminase, sortase A, tyrosinase, laccase/peroxidase or lysyl oxidase/amine oxidase. 
     
     
         15 . The composition according to  claim 1 , which is for enhancing the strength of a hair, scalp, skin, finger/toe nail, leather or fiber protein. 
     
     
         16 . The composition according to  claim 1 , wherein the aminosilane compound is contained at 0.000001 to 30 parts by weight with respect to 100 parts by weight of the total composition. 
     
     
         17 . The composition according to  claim 1 , wherein the reaction mediator is contained at 0.001 to 20 parts by weight with respect to 100 parts by weight of the total composition. 
     
     
         18 . A care product comprising the composition for enhancing protein strength of  claim 1 .