US2020141937A1PendingUtilityA1
Detection methods employing hcv core lipid and dna binding domain monoclonal antibodies
Est. expiryMar 14, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Robert N. ZiemannApril AhlbergDavid J. HawksworthBryan C. TiemanA. Scott MuerhoffChristopher MarohnicKathy Otis
G01N 33/5767C07K 2317/92G01N 2469/10C07K 2317/34G01N 2800/52G01N 2333/186C07K 2317/56C07K 16/109C07K 16/118
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Claims
Abstract
The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.
Claims
exact text as granted — not AI-modified1 .- 16 . (canceled)
17 . A system comprising:
(i) a first monoclonal antibody, or antigen-binding portion thereof, directed against an epitope in the DNA binding domain of HCV core antigen; and (ii) a second monoclonal antibody, or antigen-binding portion thereof, comprising a heavy chain variable domain amino acid sequence of SEQ ID NO: 20 and a light chain variable domain amino acid sequence of SEQ ID NO: 374 or a heavy chain variable domain amino acid sequence of SEQ ID NO: 88 and a light chain variable domain amino acid sequence of SEQ ID NO: 378.
18 .- 21 . (canceled)
22 . A monoclonal antibody comprising a heavy chain variable domain amino acid sequence of SEQ ID NO: 20 and a light chain variable domain amino acid sequence of SEQ ID NO: 374.
23 . A composition comprising the monoclonal antibody of claim 22 and a pharmaceutically acceptable carrier.
24 . A monoclonal antibody comprising a heavy chain variable domain amino acid sequence of SEQ ID NO: 88 and a light chain variable domain amino acid sequence of SEQ ID NO: 378.
25 . A composition comprising the monoclonal antibody of claim 24 and a pharmaceutically acceptable carrier.Join the waitlist — get patent alerts
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