US2020149104A1PendingUtilityA1

Additive To Improve Sequencing By Synthesis Performance

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Assignee: QIAGEN SCIENCES LLCPriority: Feb 11, 2016Filed: Nov 13, 2019Published: May 14, 2020
Est. expiryFeb 11, 2036(~9.6 yrs left)· nominal 20-yr term from priority
Inventors:James J. Dimeo
C12Q 1/6869C12Q 1/6874C12Q 1/6848
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Claims

Abstract

The invention relates to methods, compositions, devices, systems and kits are described including, without limitation, reagents and mixtures, for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods.

Claims

exact text as granted — not AI-modified
1 - 11 . (canceled) 
     
     
         12 . A system comprising primers hybridized to template in solution, said solution comprising methylenediphosphonic acid. 
     
     
         13 . The system of  claim 12 , wherein said hybridized primers and template are immobilized. 
     
     
         14 . The system of  claim 13 , wherein said hybridized primers and template are in a flow cell.

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