Lens oil having a narrow molecular weight distribution for intraocular lens devices

Abstract

A silicone oil having a mean molecular weight average greater than about 20,000 Daltons, with no more than about 3% to about 4% of the total silicone oil by weight being comprised of components having a molecular weight less than about 15,000 Daltons. In some embodiments, the silicone oil is used in intraocular lens devices.

1 .- 22 . (canceled) 
     
     
         23 . An intraocular lens device, comprising:
 an anterior region;   a posterior region;   a cavity region defined between the anterior and posterior regions; and   a fluid comprising a silicone oil disposed in the cavity region wherein the silicone oil comprises molecules having a molecular weight greater than about 2,000 Daltons, and wherein the silicone oil comprises a copolymer comprising diphenylsiloxane and dimethylsiloxane units.   
     
     
         24 . The intraocular lens device of  claim 23 , wherein the silicone oil comprises molecules having a molecular weight greater than about 3,000 Daltons. 
     
     
         25 . The intraocular lens device of  claim 23 , wherein the silicone oil comprises molecules having a molecular weight greater than about 5,000 Daltons. 
     
     
         26 . The intraocular lens device of  claim 23 , wherein the silicone oil has a refractive index of about 1.40 to about 1.60. 
     
     
         27 . The intraocular lens device of  claim 23 , wherein the silicone oil has a refractive index of about 1.49. 
     
     
         28 . The intraocular lens device of  claim 23 , wherein the silicone oil has a mean molecular weight in the range of about 20,000 Daltons to about 30,000 Daltons, 
     
     
         29 . The intraocular lens device of  claim 23 , wherein the silicone oil comprises about 20 mole % to about 25 mole % of diphenylsiloxane and about 80 mole % to about 75 mole % of dimethylsiloxane. 
     
     
         30 . The intraocular lens device of  claim 23 , wherein the copolymer further comprises substituted or unsubstituted dialkylsiloxane units. 
     
     
         31 . The intraocular lens device of  claim 23 , wherein the anterior portion comprises a refractive optical element, and wherein at least a portion of the posterior portion comprises an elastic material configured to actuate in response to a force applied thereto, causing the fluid to exert a deforming or displacing force on the refractive optical element. 
     
     
         32 . The intraocular lens device of  claim 23 , wherein at least one of the anterior region and the posterior region comprises a bulk polymeric material comprising a fluorosilicone polymer. 
     
     
         33 . An intraocular lens (IOL) device configured for implantation in a lens capsule of a patient's eye, the IOL device comprising:
 a silicone oil comprising molecules having a molecular weight greater than about 2,000 Daltons, wherein the silicone oil comprises a copolymer comprising diphenylsiloxane and dimethylsiloxane units; and   a bulk polymeric material, wherein at least a portion of the bulk material is in physical contact with the silicone oil.   
     
     
         34 . The IOL device of  claim 33 , wherein the silicone oil is entirely encapsulated by the bulk polymeric material. 
     
     
         35 . The IOL device of  claim 33 , wherein the bulk polymeric material is a fluorosilicone polymer represented by formula (I): 
       
         
           
           
               
               
           
         
         where n and m are each independently 0 to about 500; t is about 100 to about 1000; each R 1  is independently alkyl or aryl; R 2  is haloalkyl; R 3  is alkyl or haloalkyl; R 4  and R 5  are independently alkyl, haloalkyl or aryl; and each X is a crosslinker that links the polymer of formula (I) with a second polymer of formula (I). 
       
     
     
         36 . The IOL device of  claim 33 , wherein the silicone oil is purified using supercritical fluid extraction. 
     
     
         37 . The IOL device of  claim 33 , wherein the silicone oil comprises molecules having a molecular weight greater than about 3,000 Daltons. 
     
     
         38 . The IOL device of  claim 33 , wherein the silicone oil comprises molecules having a molecular weight greater than about 5,000 Daltons. 
     
     
         39 . The IOL device of  claim 33 , wherein the silicone oil has a refractive index of about 1.40 to about 1.60. 
     
     
         40 . The IOL device of  claim 33 , wherein the silicone oil has a refractive index of about 1.49. 
     
     
         41 . The IOL device of  claim 33 , wherein the silicone oil has a mean molecular weight in the range of about 20,000 Daltons to about 30,000 Daltons. 
     
     
         42 . The IOL device of  claim 33 , wherein the copolymer further comprises substituted or unsubstituted dialkylsiloxane units.