US2020163903A1PendingUtilityA1

Buffered Oxygen Therapeutic

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Assignee: NUVOX PHARMA LLCPriority: Oct 13, 2011Filed: Dec 7, 2018Published: May 28, 2020
Est. expiryOct 13, 2031(~5.3 yrs left)· nominal 20-yr term from priority
Inventors:Evan C. UngerEdmund R. Marinelli
A61K 31/02A61K 9/0026A61K 9/107A61K 31/025
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Claims

Abstract

An oxygen therapeutic composition, which includes a perfluorocarbon material having a boiling point of about 4 degrees Celsius to about 60 degrees Celsius, a lipid; a viscosity modifier; a buffer.

Claims

exact text as granted — not AI-modified
I claim: 
     
         1 . An oxygen therapeutic composition, comprising:
 a perfluorocarbon material having a boiling point of about 4 degrees Celsius to about 60 degrees Celsius;   a lipid;   a viscosity modifier;   a buffer;   wherein:   the buffer stabilizes a pH of the composition at between about 6.5 to about 7.5; and
 the composition comprises a viscosity of about 2.0 to about 3.5 mPas. 
   
     
     
         2 . The composition of  claim 1 , wherein said lipid comprises a polyethylene glycol (“PEG”) moiety. 
     
     
         3 . The composition of  claim 2 , wherein the number average molecular weight of said PEG moiety is between about 100 Daltons to about 20,000 Daltons. 
     
     
         4 . The composition of  claim 2 , wherein the number average molecular weight of said PEG moiety is between about 1,000 Daltons to about 10,000 Daltons. 
     
     
         5 . The composition of  claim 2 , wherein the number average molecular weight of said PEG moiety is between about 2,000 Daltons to about 5,000 Daltons. 
     
     
         6 . The composition of  claim 2 , wherein said lipid moiety comprises between about 10 carbons to about 24 carbons in length. 
     
     
         7 . The composition of  claim 2 , wherein said lipid moiety comprises between about 12 carbons to about 22 carbons in length. 
     
     
         8 . The composition of  claim 2 , wherein said lipid moiety comprises between about 14 carbons to about 20 carbons in length. 
     
     
         9 . The composition of  claim 3 , wherein said viscosity modifier comprises sucrose. 
     
     
         10 . The composition of  claim 9 , wherein said sucrose is present at a level of between about 28 weight percent and about 30 weight percent. 
     
     
         11 . The composition of  claim 9 , wherein said composition does not comprise fructose. 
     
     
         12 . The composition of  claim 9 , wherein said composition does not comprise glucose. 
     
     
         13 . The composition of  claim 2 , wherein said buffer is formed from equal molar parts of (0.005 M) NaH 2 PO 4  and (0.005 M) Na 2 HPO 4 . 
     
     
         14 . The composition of  claim 2 , further comprising dipalmitoylphosphatidylcholine. 
     
     
         15 . The composition of  claim 14 , further comprising dipalmitoylphosphatidylethanolamine with a covalently linked poly(ethylene glycol) moiety comprising a number average molecular weight of about 5000. 
     
     
         16 . The composition of  claim 15 , wherein said composition is homogenized to form an emulsion.

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