Imidazolidinedione derivatives

Abstract

The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.

1 . A compound of formula (VII): 
       
         
           
           
               
               
           
         
       
       wherein:
 R 1  is halo, C 1-4  alkyl, C 1-4  alkoxy, halo-C 1-4 -alkyl, halo-C 1-4 -alkoxy or cyano; 
 R 2  is H, halo, cyano, C 1-4  alkyl or C 1-4  alkoxy; with the proviso that when R 2  is H, R 1  is not in the para position; 
 X is CH or N; 
 Y is CH or N; 
 
       or a salt thereof. 
     
     
         2 . A compound according to  claim 1  wherein X is CH and Y is CH. 
     
     
         3 . A compound according to  claim 1  wherein X is N and Y is CH. 
     
     
         4 . A compound according to  claim 1  wherein X is N and Y is N. 
     
     
         5 . A compound according to  claim 1  wherein R 1  is halo, C 1-4  alkyl or C 1-4  alkoxy. 
     
     
         6 . A compound according to  claim 1  wherein R 2  is H, halo, C 1-4  alkyl or C 1-4  alkoxy. 
     
     
         7 . A compound according to  claim 1  wherein R 1  is halo, C 1-4  alkyl, C 1-4  alkoxy, halo-C 1-4 alkoxy or cyano; and R 2  is H, halo, C 1-4  alkyl or C 1-4  alkoxy. 
     
     
         8 . A compound according to  claim 1  wherein R 1  is C 1-4 alkyl, C 1-4  alkoxy or halo-C 4  alkoxy; R 2  is H, cyano or C 1-4  alkyl; X is N; and Y is N or CH. 
     
     
         9 . A compound according to  claim 1  wherein R 1  is propyl, butyl, methoxy, propoxy or trifluoromethoxy; R 2  is H, cyano or methyl; X is N; and Y is N or CH.