US2020171057A1PendingUtilityA1

Methods for Accelerated Return of Skin Integrity and for the Treatment of Impetigo

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Assignee: FOAMIX PHARMACEUTICALS LTDPriority: Oct 2, 2009Filed: Oct 30, 2019Published: Jun 4, 2020
Est. expiryOct 2, 2029(~3.2 yrs left)· nominal 20-yr term from priority
Inventors:Dov TamarkinElana GazalRita KeynanMeir EiniDavid Schuz
A61K 8/342A61K 47/06A61K 31/593A61Q 19/00A61K 31/57A61K 47/44A61K 47/02A61K 9/0048A61Q 19/10A61K 9/122A61K 31/65A61K 2800/33A61K 31/137A61K 8/361A61K 47/10A61K 8/31A61K 31/573A61K 31/4164A61K 47/24A61Q 17/04A61K 9/06A61K 9/0014A61K 9/12A61K 47/12A61K 2800/31A61K 31/192A61K 9/124A61P 17/10
72
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Claims

Abstract

Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelerating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.

Claims

exact text as granted — not AI-modified
1 - 20 . (canceled) 
     
     
         21 . A method for healing an infected acne lesion without scarring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
 (a) 60% to 90% by weight of one or more hydrophobic oils;   (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof;   (c) at least one fatty alcohol;   (d) at least one fatty acid;   (e) 0.2% to 10% by weight of a minocycline; and   
       wherein the foamable composition does not comprise a surfactant. 
     
     
         22 . The method of  claim 21 , wherein the least one fatty acid comprises stearic acid. 
     
     
         23 . The method of  claim 21 , wherein the minocycline is present in a free base form, a salt form, a hydrate form, or a complex form. 
     
     
         24 . The method of  claim 21 , wherein the minocycline comprises 1 to 4% by weight of the foamable composition. 
     
     
         25 . The method of  claim 21 , wherein the at least one fatty alcohol is selected from the group consisting of myristyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, and a mixture of two or more thereof. 
     
     
         26 . The method of  claim 21 , wherein the foamable composition further comprises fumed silica. 
     
     
         27 . The method of  claim 21 , wherein the minocycline is micronized. 
     
     
         28 . The method of  claim 21 , wherein the one or more hydrophobic oils is selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, cyclomethicone, and a mixture of two or more thereof. 
     
     
         29 . The method of  claim 21 , wherein the foamable composition comprises a second active agent. 
     
     
         30 . A method for healing an infected acne lesion without scarring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
 (a) 60% to 90% by weight of one or more hydrophobic oils;   (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof;   (c) at least one fatty alcohol;   (d) at least one fatty acid;   (e) 0.2% to 10% by weight of a minocycline; and   
       wherein the foamable composition is waterless. 
     
     
         31 . The method of  claim 30 , wherein the least one fatty acid comprises stearic acid. 
     
     
         32 . The method of  claim 30 , wherein the minocycline is present in a free base form, a salt form, a hydrate form, or a complex form. 
     
     
         33 . The method of  claim 30 , wherein the minocycline comprises 1 to 4% by weight of the foamable composition. 
     
     
         34 . The method of  claim 30 , wherein the at least one fatty alcohol is selected from the group consisting of myristyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, and a mixture of two or more thereof. 
     
     
         35 . The method of  claim 30 , wherein the foamable composition further comprises fumed silica. 
     
     
         36 . The method of  claim 30 , wherein the minocycline is micronized. 
     
     
         37 . The method of  claim 30 , wherein the one or more hydrophobic oils is selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, cyclomethicone, and a mixture of two or more thereof. 
     
     
         38 . The method of  claim 30 , wherein the foamable composition is surfactant-free. 
     
     
         39 . The method of  claim 30 , wherein the foamable composition comprises a second active agent. 
     
     
         40 . A method for healing an infected acne lesion without scarring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
 (a) 60% to 90% by weight of one or more hydrophobic oils;   (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof;   (c) at least one fatty alcohol;   (d) at least one fatty acid;   (e) 0.2% to 10% by weight of a minocycline; and   
       wherein the foamable composition has an Aw value less than about 0.9. 
     
     
         41 . The method of  claim 40 , wherein the foamable composition has an Aw value of less than about 0.7 
     
     
         42 . The method of  claim 40 , wherein the least one fatty acid comprises stearic acid. 
     
     
         43 . The method of  claim 40 , wherein the minocycline is present in a free base form, a salt form, a hydrate form, or a complex form. 
     
     
         44 . The method of  claim 40 , wherein the minocycline comprises 1 to 4% by weight of the foamable composition. 
     
     
         45 . The method of  claim 40 , wherein the at least one fatty alcohol is selected from the group consisting of myristyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, and a mixture of two or more thereof. 
     
     
         46 . The method of  claim 40 , wherein the foamable composition further comprises fumed silica. 
     
     
         47 . The method of  claim 40 , wherein the minocycline is micronized. 
     
     
         48 . The method of  claim 40 , wherein the one or more hydrophobic oils is selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, cyclomethicone, and a mixture of two or more thereof. 
     
     
         49 . The method of  claim 40 , wherein the foamable composition is surfactant-free. 
     
     
         50 . The method of  claim 40 , wherein the foamable composition comprises a second active agent. 
     
     
         51 . A method for healing an inflammatory acne lesion without scarring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
 (a) 60% to 90% by weight of one or more hydrophobic oils;   (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof;   (c) at least one fatty alcohol;   (d) at least one fatty acid;   (e) 0.2% to 10% by weight of a minocycline; and   
       wherein the foamable composition does not comprise a surfactant. 
     
     
         52 . The method of  claim 51 , wherein the least one fatty acid comprises stearic acid. 
     
     
         53 . The method of  claim 51 , wherein the minocycline is present in a free base form, a salt form, a hydrate form, or a complex form. 
     
     
         54 . The method of  claim 51 , wherein the minocycline comprises 1 to 4% by weight of the foamable composition. 
     
     
         55 . The method of  claim 51 , wherein the at least one fatty alcohol is selected from the group consisting of myristyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, and a mixture of two or more thereof. 
     
     
         56 . The method of  claim 51 , wherein the foamable composition further comprises fumed silica. 
     
     
         57 . The method of  claim 51 , wherein the minocycline is micronized. 
     
     
         58 . The method of  claim 51 , wherein the one or more hydrophobic oils is selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, cyclomethicone, and a mixture of two or more thereof. 
     
     
         59 . The method of  claim 51 , wherein the foamable composition comprises a second active agent.

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