Devices, systems, and methods for specializing, monitoring, and/or evaluating therapeutic nasal neuromodulation

Abstract

Devices, systems, and methods for specializing, monitoring, and/or evaluating therapeutic nasal neuromodulation are disclosed herein. A targeted neuromodulation system configured in accordance with embodiments of the present technology can include, for example, an evaluation/modulation assembly at a distal portion of a shaft and including a plurality of electrodes. The electrodes are configured to emit stimulating energy at frequencies for identifying and locating target neural structures and detect the resultant bioelectric properties of the tissue. The system can also include a console that maps locations of the target neural structures. The evaluation/modulation assembly can then apply therapeutic neuromodulation energy in a highly tailored neuromodulation pattern based on the mapped locations of the target neural structures. Accordingly, the system provides therapeutic neuromodulation to highly specific target structures while avoiding non-target structures to reduce collateral effects.

1 .- 44 . (canceled) 
     
     
         45 . A treatment system comprising:
 a treatment device comprising an end effector comprising a feedback element and a treatment element; and   a console including a controller operably associated with the treatment device, the controller having a computer-readable medium carrying instructions, which when executed by the controller, causes the console to: receive feedback from the feedback element of the end effector, determine locations of target neural structures and vessels at a treatment site based on the received feedback, generate a treatment pattern that distinguishes the locations of the target neural structures from the locations of the vessels at the treatment site, and apply treatment via the treatment element of the end effector to the treatment site according to the treatment pattern such that treatment is provided to the target neural structures and not the vessels.   
     
     
         46 . The system of  claim 45 , wherein the feedback from the feedback element further allows identification of additional anatomical structures. 
     
     
         47 . The system of  claim 45 , wherein the feedback from the feedback element further allows confirmation of efficacy of the treatment and/or enhancement of performance of the system. 
     
     
         48 . The system of  claim 45 , wherein the feedback from the feedback element further allows for monitoring of neural activity and/or temperature at the target neural structures during treatment. 
     
     
         49 . The system of  claim 48 , wherein the feedback from the feedback element further allows for automatically shut off the system when the neural activity and/or temperature reaches a predetermined threshold. 
     
     
         50 . The system of  claim 45 , wherein the console comprises a display and feedback is communicated to a user via the display. 
     
     
         51 . The system of  claim 50 , wherein the display is selected from the group consisting of:
 a monitor, a touchscreen, and a user interface.   
     
     
         52 . The system of  claim 45 , wherein the feedback element comprises one or more electrodes. 
     
     
         53 . The system of  claim 52 , wherein the one or more electrodes provide feedback that comprises one or more resistance values for the target neural structures and the vessels at the treatment site. 
     
     
         54 . The system of  claim 53 , wherein the resistance feedback is shown as high resolution spatial grid on a display of the console. 
     
     
         55 . The system of  claim 45 , wherein the treatment element comprises a cryotherapy treatment element. 
     
     
         56 . The system of  claim 45 , wherein the treatment element comprises a delivery state and an expanded state. 
     
     
         57 . The system of  claim 45 , wherein the treatment element is configured to deliver radiofrequency energy. 
     
     
         58 . The system of  claim 57 , wherein the treatment element comprises a plurality of electrodes. 
     
     
         59 . The system of  claim 58 , wherein the plurality of electrodes are arranged on a plurality of struts. 
     
     
         60 . The system of  claim 45 , further comprising a shaft 
     
     
         61 . The system of  claim 60 , further comprising a handle coupled to the shaft, wherein the handle is configured to allow manipulation of the shaft. 
     
     
         62 . The system of  claim 60 , wherein the shaft is steerable. 
     
     
         63 . The system of  claim 62 , wherein the shaft comprises a bend radius. 
     
     
         64 . The system of  claim 62 , wherein the shaft is steerable in at least two different directions.