Microdevice and method for transdermal delivery and sampling of active substances

Abstract

A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.

1 - 15 . (canceled) 
     
     
         16 . A kit for delivering an agent to a mammal, comprising:
 a microdevice comprising a structure selected from microneedles, microblades, microknives, and combinations thereof;   a wet formulation comprising a bioactive agent;   a mechanism to provide for a driving force to the microdevice; and   an occlusive layer.   
     
     
         17 . The kit of  claim 16 , wherein the driving force is ultrasound, iontophoresis, radio frequency or heat gradient. 
     
     
         18 . The kit of  claim 16 , further comprising
 an applicator of the microdevice for applying the microdevice to an area of skin of a mammal.   
     
     
         19 . The kit of  claim 16 , further comprising
 a driving force mechanism for driving the bioactive agent to transport through the stratum corneum of the area of skin into the mammal.   
     
     
         20 . The kit of  claim 16 , wherein the mammal has a medical condition,
 wherein the agent is a natural or synthetic vaccine selected from the group consisting of proteins, peptides, paclitaxel, docetaxel, vaccines, protein vaccines, peptide vaccines, gene vaccines and DNA vaccines, and   wherein the vaccine is against influenza (flu), diphtheria, tetanus, pertussis (DTaP), measles, mumps, rubella (MMR), hepatitis B, polio,  Haemophilus influenzae  type b, chickenpox, tuberculosis, anthrax, yellow fever, rabies, AIDS, cancers, meningococcus, SARS and cholera.   
     
     
         21 . The kit of  claim 16 , wherein the formulation comprises elastic liposomes encapsulating the agent. 
     
     
         22 . The kit of  claim 16 , wherein the formulation does not comprises elastic liposomes. 
     
     
         23 . The kit of  claim 21 , wherein the elastic liposome comprises deformable nanoparticles. 
     
     
         24 . The kit of  claim 16 , wherein the formulation is a topical or systemic delivery formulation selected from a skin patch, cream, ointment, or lotion. 
     
     
         25 . The kit of  claim 16 , wherein the driving force mechanism comprises ultrasound, or radio frequency, heat gradient or iontophoresis device. 
     
     
         26 . The kit of  claim 16 , wherein the agent is a pain relieving agent. 
     
     
         27 . The kit of  claim 26 , wherein the pain relieving agent is lidocaine, tetracaine, dyclonine or a combination of thereof, and
 wherein the formulation is lotion, cream, gel patch, ointment or skin patch comprising lidocaine, tetracaine, dyclonine or a combination thereof.   
     
     
         28 . The kit of  claim 16 , wherein the formulation is a topical or systemic delivery formulation selected from a skin patch, cream, ointment, or lotion. 
     
     
         29 . The kit of  claim 16 , wherein the applicator is a mechanical applicator. 
     
     
         30 . The kit of  claim 16 , wherein the formulation is a wet skin patch.