Textile engineered prosthetics, bioreactors, and methods of manufacturing textile engineered prosthetics

Abstract

A bioreactor system includes a bioreactor container having a first compartment, a second compartment, a first membrane separating the first compartment from the second compartment, a third compartment, and a second membrane separating the third compartment from the first compartment or the second compartment and the system further includes a tissue scaffold integrated with the bioreactor container in the second compartment to form a single bioreactor unit. One or more fluids can be added to one or more of the compartments.

What is claimed is: 
     
         1 . A bioreactor system comprising:
 a bioreactor container comprising a first compartment, a second compartment, a first membrane separating the first compartment from the second compartment, a third compartment, and a second membrane separating the third compartment from the first compartment or the second compartment; and   a tissue scaffold integrated with the bioreactor container in the second compartment to form a single bioreactor unit.   
     
     
         2 . The bioreactor system of  claim 1  wherein the tissue scaffold includes a textile. 
     
     
         3 . The bioreactor system of  claim 2  wherein the tissue scaffold includes a woven textile. 
     
     
         4 . The bioreactor system of  claim 1  further comprising a buffer solution in the first compartment of the bioreactor container. 
     
     
         5 . The bioreactor system of  claim 4  wherein the buffer solution comprises a pharmaceutical ingredient. 
     
     
         6 . The bioreactor system of  claim 4  wherein the buffer solution exhibits a pH of between 4 and 10. 
     
     
         7 . The bioreactor system of  claim 1  further comprising a bio-fluid in the third compartment of the bioreactor container. 
     
     
         8 . The bioreactor system of  claim 7  wherein the bio-fluid comprises cells, growth-factors, or combinations thereof. 
     
     
         9 . The bioreactor system of  claim 1  wherein a wall of the bioreactor includes polyethylene. 
     
     
         10 . The bioreactor system of  claim 9  wherein at least one of the first membrane or the second membrane includes polyethylene. 
     
     
         11 . The bioreactor system of  claim 1  wherein at least one of the first membrane or the second membrane includes polyethylene. 
     
     
         12 . The bioreactor system of  claim 1  wherein a wall of the bioreactor and at least one membrane include the same material. 
     
     
         13 . The bioreactor of  claim 1  further comprising a valve configured to communicatively connect the first compartment to the second compartment. 
     
     
         14 . The bioreactor of  claim 1  further comprising a valve configured to communicatively connect the third compartment to the first compartment or the second compartment. 
     
     
         15 . The bioreactor system of  claim 1  wherein at least one of the first membrane or the second membrane includes a hydrogel. 
     
     
         16 . The bioreactor system of  claim 1  further comprising a buffer solution in the first compartment of the bioreactor container and a bio-fluid in the third compartment of the bioreactor. 
     
     
         17 . The bioreactor system of  claim 1  further comprising a buffer solution in the first compartment of the bioreactor container wherein the buffer solution comprises a pharmaceutical ingredient; and a bio-fluid in the third compartment of the bioreactor wherein the bio-fluid comprises cells, growth-factors, or combinations thereof. 
     
     
         18 . The bioreactor system of  claim 17  wherein the buffer solution includes a predetermined cell composition and the bio-fluid includes a predetermined pharmaceutical composition, wherein the cell composition and pharmaceutical composition are personalized for an individual patient in response to a determination by a physician.