Combination therapy of phosphate binders and vitamin k

Abstract

A method of treating chronic kidney disease including administering to a subject in need thereof a combination of a vitamin K and a phosphate binder.

1 . A method of treating chronic kidney disease comprising administering to a subject in need thereof a combination of a vitamin K in a first amount and a phosphate binder in a second amount. 
     
     
         2 . The method according to  claim 1 , wherein the vitamin K comprises a vitamin K 2 . 
     
     
         3 . The method according to  claim 2 , wherein the vitamin K 2  comprises MK-7. 
     
     
         4 . The method according to  claim 1 , wherein the first amount and the second amount are sufficient to reduce the subject's serum phosphate level to 4.5 mg/dL or less. 
     
     
         5 . The method according to  claim 1 , wherein the first amount and the second amount are sufficient to reduce the subject's dp-ucMGP level to no more than about 700 pmol/L. 
     
     
         6 . The method according to  claim 1 , wherein the first amount and the second amount are sufficient to prevent onset of cardiovascular disease in the subject. 
     
     
         7 . The method according to  claim 1 , wherein the first amount and the second amount are sufficient to prevent vascular calcification in the subject and/or reduce the subject's vascular calcification. 
     
     
         8 . The method according to  claim 1 , wherein the first amount and the second amount are sufficient to reduce the subject's non-bone calcium level. 
     
     
         9 . The method according to  claim 1 , wherein the first amount and the second amount are sufficient to reduce a rate of bone degeneration in the subject. 
     
     
         10 . The method according to  claim 1 , wherein the vitamin K and the phosphate binder are administered simultaneously. 
     
     
         11 . A method of treating cardiovascular disease comprising administering to a subject in need thereof a combination of a vitamin K in a first amount and a phosphate binder in a second amount, wherein the cardiovascular diseases is characterized at least by vascular calcification. 
     
     
         12 . A synergistic combination of a vitamin K in a first amount and a phosphate binder in a second amount. 
     
     
         13 . The combination according to  claim 8 , wherein the vitamin K comprises a vitamin K 2 . 
     
     
         14 . The combination according to  claim 8 , wherein the vitamin K 2  comprises MK-7.