Method for suppressing brain metastasis

Abstract

A method for suppressing brain metastasis includes administering an miR-181c expression inhibitor, an miR-181c activity inhibitor, or an exosome secretion inhibitor as an active ingredient.

What is claimed is: 
     
         1 . A method for suppression of brain metastasis, comprising administering one or more agents selected from the group consisting of an miR-181c expression inhibitor, an miR-181c activity inhibitor, and an exosome secretion inhibitor as an active ingredient to a subject in need of the suppression of brain metastasis. 
     
     
         2 . The method of  claim 1 , wherein the one or more agents selected from the group consisting of the miR-181c expression inhibitor, the miR-181c activity inhibitor, and the exosome secretion inhibitor is an agent selected from the following;
 (i) an antisense oligonucleotide, aptamer, or siRNA to pri-miR-181c or pre-miR-181c;   (ii) an antisense oligonucleotide to miR-181c, an aptamer that specifically binds to miR-181c, siRNA against miR-181c, or miRNA mimetics of miR-181c;   (iii) an antisense oligonucleotide, aptamer, or siRNA against the nSMase2 and/or RAB27B gene; or   (iv) an antibody or an immunoreactive fragment thereof against nSMase2 and/or RAB27B; peptide mimetics or an aptamer that specifically binds to nSMase2 and/or RAB27B; or an antagonist of nSMase2 and/or RAB27B.