Preparation of occlusive dressings

Abstract

A method of preparing an occlusive wound dressing involves preparing a slurry of an occlusive composition with a hydrophobic compound and a bacteriostatic agent, applying the occlusive composition on a fabric to produce a coated fabric, disposing the coated fabric in packaging, adding water onto at least one of the coated fabric and the packaging, sealing the packaging containing the coated fabric, and irradiating the sealed package to sterilize and produce the occlusive wound dressing. The occlusive wound dressing has from about 60 wt % to about 75 wt % hydrophobic compound, from about 2 wt % to about 5 wt % bacteriostatic agent, from about 2 wt % to about 5 wt % water, and from about 5 wt % to about 36 wt % fabric.

What is claimed: 
     
         1 - 19 . (canceled) 
     
     
         20 . A kit comprising:
 a wound dressing; and   a first packaging member,   wherein the first packaging member comprises a polyethylene film on at least a portion thereof, and wherein the wound dressing comprises petrolatum, bismuth tribromophenate, water, and fabric.   
     
     
         21 . The kit of  claim 20  further comprising a second packaging member. 
     
     
         22 . The kit of  claim 21 , wherein the first packaging member and the second packaging member are sealed together via the polyethylene film to form a sealed package. 
     
     
         23 . The kit of  claim 22 , wherein the sealed package has been exposed to a total dose of gamma radiation in a range of from about 15 kGy to about 55 kGy. 
     
     
         24 . The kit of  claim 20 , wherein the first packaging member comprises a pocket, and wherein at least a portion of the wound dressing is disposed in the pocket. 
     
     
         25 . The kit of  claim 20 , wherein the wound dressing further comprises an antimicrobial agent. 
     
     
         26 . The kit of  claim 25 , wherein the antimicrobial agent is selected from the group consisting of polyhexamethylene biguanide; 2,4,4′-trichloro-2′-hydroxydiphenyl ether; chlorhexidine and salts thereof; silver and salts or complexes thereof; polymyxin, tetracycline; aminoglycoside compounds; bacitracin; neomycin; chloramphenicol; miconazole; and combinations thereof. 
     
     
         27 . The kit of  claim 26 , wherein the antimicrobial agent is present in the wound dressing in an amount from about 500 ppm to about 3,000 ppm. 
     
     
         28 . The kit of  claim 20 , wherein wound dressing comprises from about 60 wt % to about 75 wt % petrolatum. 
     
     
         29 . The kit of  claim 20 , wherein wound dressing comprises from about 2 wt % to about 5 wt % bismuth tribromophenate. 
     
     
         30 . The kit of  claim 20 , wherein wound dressing comprises from about 2 wt % to about 15 wt % water. 
     
     
         31 . The kit of  claim 20 , wherein wound dressing comprises from about 5 wt % to about 36 wt % fabric. 
     
     
         32 . The kit of  claim 20 , wherein wound dressing is an occlusive wound dressing. 
     
     
         33 . The kit of  claim 20 , wherein the fabric comprises at least one of cotton, rayon, cellulose acetate, and polyimide. 
     
     
         34 . The kit of  claim 20 , wherein the fabric is a woven fabric. 
     
     
         35 . The kit of  claim 34 , wherein the woven fabric comprises first yarns and second yarns that are different from the first yarns. 
     
     
         36 . The kit of  claim 35 , wherein the first yarns comprise cellulosic fibers and the second yarns comprise non-adherent polymeric fibers. 
     
     
         37 . The kit of  claim 20 , wherein the fabric is a non-woven fabric. 
     
     
         38 . A method of preparing a wound dressing, comprising:
 preparing a slurry of an occlusive composition comprising a petrolatum and bismuth tribromophenate;   applying a portion of the occlusive composition on a fabric comprised of at least one of cotton, polyester, rayon, cellulose acetate, and polyimide to produce a coated fabric;   disposing the coated fabric on a portion of a first packaging member;   introducing water on at least one of the coated fabric and the portion of the first packaging member;   sealing the first packaging member to a second packaging member to produce a sealed package containing the coated fabric with the occlusive composition; and   irradiating the sealed package to produce the wound dressing.   
     
     
         39 . A wound dressing comprising petrolatum, bismuth tribromophenate, water, and fabric.