Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level

Abstract

The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.

We claim: 
     
         1 . A method for treating a mammalian subject having diabetes or a related disorder selected from impaired glucose tolerance, impaired fasting glucose, insulin resistance, metabolic syndrome, postprandial hyperglycemia and/or overweight/obesity comprising administering to said subject an effective amount of (i) baclofen or a salt or sustained release formulation thereof, in combination with (ii) metformin or a salt or sustained release formulation thereof. 
     
     
         2 . The method of  claim 1 , wherein the subject has type 2 diabetes. 
     
     
         3 . The method of  claim 1 , wherein said combination is administered repeatedly to the subject. 
     
     
         4 . The method of  claim 1 , wherein the compounds in said combination are formulated for a simultaneous, sequential or separate administration to the subject. 
     
     
         5 . The method of  claim 1 , wherein the compounds in said combination are formulated in a single composition. 
     
     
         6 . The method of  claim 1 , wherein said combination further comprises a pharmaceutically acceptable carrier or excipient. 
     
     
         7 . A method for controlling blood glucose level in a mammalian subject in need thereof, comprising administering to said subject a combination as defined in  claim 1 . 
     
     
         8 . The method of  claim 7 , wherein the subject has type 2 diabetes. 
     
     
         9 . The method of  claim 7 , wherein said combination is administered repeatedly to the subject. 
     
     
         10 . The method of  claim 7 , wherein the compounds in said combinations are formulated for a simultaneous, sequential or separate administration to the subject. 
     
     
         11 . The method of  claim 7 , wherein the compounds in said combination are formulated in a single composition. 
     
     
         12 . The method of  claim 7 , wherein said combination further comprises a pharmaceutically acceptable carrier or excipient. 
     
     
         13 . A method for increasing or stimulating glucose uptake in adipocytes and/or muscular cells in a mammalian subject in need thereof, comprising administering to said subject a combination as defined in  claim 1 . 
     
     
         14 . The method of  claim 13 , wherein the subject has type 2 diabetes. 
     
     
         15 . The method of  claim 13 , wherein said combination is administered repeatedly to the subject. 
     
     
         16 . A method for decreasing apoptosis of pancreatic beta cells in a mammalian subject in need thereof, comprising administering to said subject a combination as defined in  claim 1 . 
     
     
         17 . The method of  claim 16 , wherein the subject has type 2 diabetes. 
     
     
         18 . The method of  claim 16 , wherein said combination is administered repeatedly to the subject. 
     
     
         19 . A composition comprising (i) baclofen or a salt or sustained release formulation thereof, in combination with (ii) metformin or a salt or sustained release formulation thereof. 
     
     
         20 . The composition of  claim 19 , further comprising a pharmaceutically acceptable carrier or excipient.