Tissue occluding agent

Abstract

The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

1 - 15 . (canceled) 
     
     
         16 . An aqueous solution for tissue occluding comprising a peptide, wherein the amino acid sequence of the peptide consists of an amino acid sequence as set forth in SEQ ID NO:2. 
     
     
         17 . The aqueous solution of  claim 16 , wherein the aqueous solution comprises 1 w/v % to 3 w/v % of the peptide. 
     
     
         18 . The aqueous solution of  claim 16 , further comprising a small molecule drug. 
     
     
         19 . The aqueous solution of  claim 18 , wherein the small molecule drug is selected from the group consisting of glucose, saccharose, purified saccharose, lactose, maltose, trehalose, dextran, iodine, lysozyme chloride, dimethylisopropylazulene, tretinoin tocoferil, povidone iodine, alprostadil alfadex, anise alcohol, isoamyl salicylate, α,α-dimethylphenylethyl alcohol, bacdanol, helional, sulfazin silver, bucladesine sodium, alprostadil alfadex, gentamycin sulfate, tetracycline hydrochloride, sodium fusidate, mupirocin calcium hydrate and isoamyl benzoate. 
     
     
         20 . A hemostatic agent for hemorrhage of blood in a condition of reduced clotting function induced by addition of an anticoagulant, comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         21 . A hemostatic agent for a hemorrhaging wound surface of a parenchymal organ, comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         22 . A hemostatic agent for arterial hemorrhage and phleborrhagia, comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         23 . An agent for preventing bile leakage from the gall bladder or bile duct, comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         24 . An agent for preventing hemorrhage or air leakage from the lungs, comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         25 . A mucosal tissue infusion for elevating an excision site in endoscopic demucosation, the infusion comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         26 . An agent for preventing hemorrhage and body fluid leakage from an excision site in a method of excising a mucosal tissue section that has been elevated by infusion of a liquid into the mucosal tissue, the agent comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         27 . A hemostatic agent applicable for transcatheter application for hemostasis from an excision site in endoscopic demucosation, the agent comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         28 . An arteriovenous occluding agent for arteriovenous occlusion or a varix sclerotherapy agent for varix sclerotherapy, comprising the aqueous solution of any one of  claims 16  to  19 . 
     
     
         29 . The arteriovenous occluding agent of  claim 28 , further comprising an anticancer agent and/or a contrast agent. 
     
     
         30 . A powder for tissue occluding comprising a peptide, wherein the amino acid sequence of the peptide consists of an amino acid sequence as set forth in SEQ ID NO:2. 
     
     
         31 . The powder of  claim 30 , further comprising a small molecule drug. 
     
     
         32 . The powder of  claim 31 , wherein the small molecule drug is selected from the group consisting of glucose, saccharose, purified saccharose, lactose, maltose, trehalose, dextran, iodine, lysozyme chloride, dimethylisopropylazulene, tretinoin tocoferil, povidone iodine, alprostadil alfadex, anise alcohol, isoamyl salicylate, α,α-dimethylphenylethyl alcohol, bacdanol, helional, sulfazin silver, bucladesine sodium, alprostadil alfadex, gentamycin sulfate, tetracycline hydrochloride, sodium fusidate, mupirocin calcium hydrate and isoamyl benzoate. 
     
     
         33 . A gauze, bandage, or lining comprising a tissue occluding agent comprising a peptide, wherein the peptide has an amino acid sequence as set forth in SEQ ID NO:2. 
     
     
         34 . An atomizing sprayer comprising a power or solution comprising a tissue occluding agent comprising a peptide, wherein the peptide has an amino acid sequence as set forth in SEQ ID NO:2.