Methods for treatment of lung damage and for inhibition of lung fibrosis

Abstract

A method of stimulating the synthesis of human and animal patient lung and sinus surfactants for treatment of lung damage needed to increase lung functions, increase oxygen levels, increase the synthesis of nasal nitric oxide and for inhibition of lung fibrosis while reducing, coughing, lung tightness, mouth breathing, and reducing congestion, for treating patients with a pulmonary condition including asthma, chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, pulmonary fibrosis, allergic rhinitis, sinusitis, sleep apnea and lung cancer, includes: contacting mammalian cells with a therapeutically effective amount of a composition, said composition including the following constituents: sodium pyruvate; a phosphate; a salt of calcium; and, a salt of magnesium. Preferably, the composition is a saline solution.

What is claimed is: 
     
         1 . A method of stimulating the synthesis of human and animal patient lung and sinus surfactants for treatment of lung damage needed to increase lung functions, increase oxygen levels, increase the synthesis of nasal nitric oxide and for inhibition of lung fibrosis while reducing, coughing, lung tightness, mouth breathing, and reducing congestion, for treating patients with a pulmonary condition including asthma, chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, pulmonary fibrosis, allergic rhinitis, sinusitis, sleep apnea and lung cancer, which comprises:
 contacting mammalian cells with a therapeutically effective amount of a composition, said composition including the following constituents:   a) sodium pyruvate;   b) a phosphate;   c) a salt of calcium; and,   d) a salt of magnesium;   
       wherein said composition contains the following amounts of said constituents: sodium pyruvate ranges from about 0.0001 mg to about 1 gram; and ranges from 0.0001 mg to about 1 gram for each of the following constituents: phosphate, salt of calcium and salt of magnesium. 
     
     
         2 . The method of  claim 1  wherein said composition is a saline solution. 
     
     
         3 . The method of  claim 1 , wherein the phosphate is selected from the group consisting of calcium phosphate, a potassium phosphate, magnesium phosphate, and zinc phosphate, and combinations thereof. 
     
     
         4 . The method of  claim 3 , wherein said phosphate is a calcium phosphate selected from the group consisting of calcium phosphate, di-calcium phosphate and combinations thereof. 
     
     
         5 . The method of  claim 3 , wherein said phosphate is a potassium phosphate selected from the group consisting of potassium phosphate, di-potassium phosphate, tri-potassium phosphate, and combinations thereof. 
     
     
         6 . The method of  claim 1 , wherein said salt of calcium is selected from the group consisting of calcium chloride, calcium carbonate, calcium acetate, calcium citrate, calcium lactate, calcium sulfate, and combinations thereof. 
     
     
         7 . The method of  claim 1 , wherein said salt of magnesium is selected from the group consisting of magnesium chloride, magnesium phosphate, magnesium sulfate, magnesium bicarbonate, and combinations thereof. 
     
     
         8 . The method of  claim 1 , wherein the phosphate is selected from the group consisting of calcium phosphate, a potassium phosphate, magnesium phosphate, and zinc phosphate, and combinations thereof, and wherein said salt of magnesium is selected from the group consisting of magnesium chloride, magnesium phosphate, magnesium sulfate, magnesium bicarbonate, and combinations thereof. 
     
     
         9 . The method of  claim 1 , wherein said salt of magnesium is selected from the group consisting of magnesium chloride, magnesium phosphate, magnesium sulfate, magnesium bicarbonate, and combinations thereof, and wherein said salt of calcium is selected from the group consisting of calcium chloride, calcium carbonate, calcium acetate, calcium citrate, calcium lactate, calcium sulfate, and combinations thereof. 
     
     
         10 . The method of  claim 1 , wherein the phosphate is selected from the group consisting of calcium phosphate, a potassium phosphate, magnesium phosphate, and zinc phosphate, and combinations thereof, and wherein said salt of calcium is selected from the group consisting of calcium chloride, calcium carbonate, calcium acetate, calcium citrate, calcium lactate, calcium sulfate, and combinations thereof. 
     
     
         11 . The method of  claim 1 , wherein the phosphate is selected from the group consisting of calcium phosphate, a potassium phosphate, magnesium phosphate, and zinc phosphate, and combinations thereof, and wherein said salt of magnesium is selected from the group consisting of magnesium chloride, magnesium phosphate, magnesium sulfate, magnesium bicarbonate, and combinations thereof, and wherein said salt of calcium is selected from the group consisting of calcium chloride, calcium carbonate, calcium acetate, calcium citrate, calcium lactate, calcium sulfate, and combinations thereof. 
     
     
         12 . The method of  claim 1 , wherein said composition is a saline solution containing sodium pyruvate, calcium chloride, potassium phosphate and magnesium chloride ions in solution. 
     
     
         13 . The method of  claim 1 , wherein said composition contains the following amounts of said constituents: sodium pyruvate ranges from about 0.01 mg to about 1 gram; and ranges from 0.0001 mg to about 1 gram for each of the following constituents: phosphate, salt of calcium and salt of magnesium. 
     
     
         14 . The method of  claim 1 , wherein said composition contains the following amounts of said constituents: sodium pyruvate ranges from about 0.01 mg to about 1 gram; and ranges from 0.0001 mg to about 1 gram for each of the following constituents: phosphate, salt of calcium and salt of magnesium. 
     
     
         15 . The method of  claim 11 , wherein said composition contains the following amounts of said constituents: sodium pyruvate ranges from about 0.01 mg to about 1 gram; and ranges from 0.0001 mg to about 1 gram for each of the following constituents: phosphate, salt of calcium and salt of magnesium. 
     
     
         16 . The method of  claim 12 , wherein said composition contains the following amounts of said constituents: sodium pyruvate ranges from about 0.01 mg to about 1 gram; and ranges from 0.0001 mg to about 1 gram for each of the following constituents: phosphate, salt of calcium and salt of magnesium. 
     
     
         17 . The method of  claim 1 , wherein a therapeutic agent is administered prior to contacting said mammalian cells with said composition. 
     
     
         18 . The method of  claim 1 , wherein a therapeutic agent is administered simultaneously with contacting said mammalian cells with said composition. 
     
     
         19 . The method of  claim 1 , wherein a therapeutic agent is administered after contacting said mammalian cells with said composition. 
     
     
         20 . The method of  claim 1 , wherein said method includes cancer treatment and an oral diet is administered before and after said cancer treatment and said oral diet includes the composition set forth in the method of  claim 1 .