Mesh compositions and methods of production

Abstract

Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.

What is claimed is: 
     
         1 . A composition for treatment, comprising:
 a synthetic material substrate; and   a slurry at least partially encasing the synthetic material substrate;   wherein the slurry is in the form of a dried slurry that prior to drying included a mixture of between 5% and 35% by volume of a collagen-containing tissue matrix subjected to an acid-swelling process mixed with a remainder portion of the collagen-containing tissue matrix not subjected to the acid-swelling process.   
     
     
         2 . The composition of  claim 1 , wherein the slurry is in the form of the dried slurry that prior to drying was formed by subjecting a portion of a collagen-containing tissue matrix to the acid swelling process to produce an acid-swelled tissue matrix, resulting in (i) the acid-swelled tissue matrix including the portion of the collagen-containing tissue matrix, and (ii) the remainder portion of the collagen-containing tissue matrix not subjected to the acid-swelling process, and mixing the acid swelled tissue matrix with the remainder portion of the collagen-containing tissue matrix to produce the slurry having between 5% and 35% by volume of the acid-swelled tissue matrix. 
     
     
         3 . The composition of  claim 1 , wherein the synthetic material substrate is embedded in the slurry. 
     
     
         4 . The composition of  claim 1 , wherein the slurry has between 5% and 25% by volume of the acid-swelled tissue matrix. 
     
     
         5 . The composition of  claim 1 , wherein the slurry has between 5% and 10% by volume of the acid-swelled tissue matrix. 
     
     
         6 . The composition of  claim 1 , wherein the acid swelling process comprises suspending the portion of the collagen-containing tissue matrix in acid and incubating the portion of the collagen-containing tissue matrix in the acid until swelling occurs. 
     
     
         7 . The composition of  claim 1 , wherein prior to drying, the collagen-containing tissue matrix was decellularized. 
     
     
         8 . The composition of  claim 1 , wherein prior to drying, the slurry was resuspended in a buffer. 
     
     
         9 . The composition of  claim 1 , comprising an antimicrobial compound incorporated into the composition. 
     
     
         10 . The composition of  claim 1 , comprising an anti-inflammatory compound incorporated into the composition. 
     
     
         11 . The composition of  claim 1 , wherein the synthetic material substrate comprises at least one of a porous foam, a planar mesh, a monofilament woven material, a multifilament woven material, multi-leveled layers, or multi-directional layers. 
     
     
         12 . The composition of  claim 1 , wherein a tensile strength of the synthetic material substrate is greater than a tensile strength of the collagen-containing tissue matrix. 
     
     
         13 . The composition of  claim 1 , wherein the synthetic material substrate comprises textured surfaces. 
     
     
         14 . The composition of  claim 1 , wherein the collagen-containing tissue matrix comprises an acellular tissue matrix. 
     
     
         15 . The composition of  claim 1 , wherein prior to drying, the collagen-containing tissue matrix comprises a group of collagen-containing tissue matrix fragments, at least a portion of the collagen-containing tissue matrix fragments including frayed ends. 
     
     
         16 . The composition of  claim 1 , wherein prior to drying, a portion of the slurry is poured into a mold to cover a bottom of the mold with the slurry, the synthetic material substrate coated with the slurry is positioned into the mold on the slurry, the slurry is poured over the synthetic material substrate positioned in the mold to cover the synthetic material substrate, and the surgical material is freeze dried to combine the collagen-containing tissue matrix and the synthetic material substrate. 
     
     
         17 . The composition of  claim 1 , wherein the synthetic material substrate and at least a portion of the slurry are freeze dried to form the composition, wherein freeze drying the synthetic material substrate and at least the portion of the slurry produces a smooth layer or skin on an outer surface of the composition. 
     
     
         18 . The composition of  claim 17 , wherein the portion of the slurry and the synthetic material substrate are compressed after freeze drying, wherein compressing the portion of the slurry and the synthetic material substrate embeds the slurry into the synthetic material substrate. 
     
     
         19 . The composition of  claim 1 , wherein at least a portion of the slurry is mechanically forced, moved or rubbed into the synthetic material substrate, mechanically forcing, moving or rubbing at least the portion of the slurry into the synthetic material substrate forces the portion of the slurry into openings in an outer surface of the synthetic material substrate. 
     
     
         20 . A method of treatment, comprising:
 selecting an anatomic site; and   implanting in or on the anatomic site a composition according to  claim 1 .