Il-2 conjugates and methods of use thereof

Abstract

Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

What is claimed is: 
     
         1 . An IL-2 conjugate comprising the amino acid sequence of SEQ ID NO: 3 in which at least one amino acid residue in the IL-2 conjugate at an amino acid position selected from K35, F42, F44, K43, E62, P65, R38, T41, E68, Y45, V69, and L72 in reference to the amino acid positions within SEQ ID NO: 1, is replaced by the structure of Formula (I): 
       
         
           
           
               
               
           
         
         wherein:
 Z is CH 2  and Y is 
 
       
       
         
           
           
               
               
           
         
         
           Y is CH 2  and Z is 
         
       
       
         
           
           
               
               
           
         
         
           Z is CH 2  and Y is or 
         
       
       
         
           
           
               
               
           
         
         
           Y is CH 2  and Z is 
         
       
       
         
           
           
               
               
           
         
         
           W is a PEG group having an average molecular weight selected from 20 kDa, 25 kDa, 30 kDa, 35 kDa, 40 kDa, 45 kDa, 50 kDa, and 60 kDa; and 
           X has the structure: 
         
       
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, solvate, or hydrate thereof.