Method of treating renal system damage

Abstract

Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.

1 . A method of treating renal system damage in a subject, comprising:
 orally administering to the subject an effective amount of a nitrated fatty acid,   wherein the renal system damage is selected from a group consisting of nephrotoxicity, distortion of the overall renal morphology, dilation of renal tubules, appearance of protein cast, oxidative stress, necrosis, and apoptosis of organ cells.   
     
     
         2 . The method of  claim 1 , wherein the nitrated fatty acid is a monosaturated fatty acid or a polyunsaturated fatty acid. 
     
     
         3 . The method of  claim 2 , wherein the nitrated fatty acid is nitro-oleic acid. 
     
     
         4 . The method of  claim 3 , wherein the nitrated fatty acid is selected from the group consisting of 9-nitrooelic acid, 10-nitrooleic acid, and combinations thereof. 
     
     
         5 . The method of  claim 4 , wherein the nitrated fatty acid is 9-nitrooelic acid. 
     
     
         6 . The method of  claim 4 , wherein the nitrated fatty acid is 10-nitrooleic acid. 
     
     
         7 . The method of  claim 5 , wherein the effective amount is from about 1 milligram per day to about 500 milligrams per day. 
     
     
         8 . The method of  claim 6 , wherein the effective amount is from about 1 milligram per day to about 500 milligrams per day. 
     
     
         9 . The method of  claim 1 , wherein the renal system damage is nephrotoxicity. 
     
     
         10 . The method of  claim 1 , wherein the renal system damage is distortion of the overall renal morphology. 
     
     
         11 . The method of  claim 1 , wherein the renal system damage is dilation of renal tubules. 
     
     
         12 . The method of  claim 1 , wherein the renal system damage is appearance of protein cast. 
     
     
         13 . The method of  claim 1 , wherein the renal system damage is oxidative stress. 
     
     
         14 . The method of  claim 1 , wherein the renal system damage is necrosis. 
     
     
         15 . The method of  claim 1 , wherein the renal system damage is apoptosis of organ cells.