US2020255426A1PendingUtilityA1
Bromodomain Inhibitors

Assignee: ABBVIE INCPriority: Apr 15, 2016Filed: Apr 27, 2020Published: Aug 13, 2020
Est. expiryApr 15, 2036(~9.7 yrs left)· nominal 20-yr term from priority
Inventors:Steven D. Fidanze Lisa A. Hasvold Dachun Liu Keith F. Mcdaniel John K. Pratt Michael R. Schrimpf George S. Sheppard Le Wang Bing Li
A61K 31/407C07D 471/04A61P 35/00A61K 31/437C07D 487/04A61P 31/18A61P 13/12A61K 31/444A61P 3/10A61P 1/18A61P 9/00A61P 17/00A61P 35/02A61P 3/00A61P 17/04A61P 15/16A61P 3/06A61P 17/06A61P 29/00A61P 37/06A61P 3/04A61P 19/06A61P 21/00A61P 25/00A61P 19/00A61P 1/04A61P 25/28A61P 1/16A61P 9/10A61P 19/02A61P 11/00A61P 11/06A61P 31/04A61P 27/02
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Claims
Abstract

The present invention provides for compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 6 , X 1 , and X 2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).
Claims

exact text as granted — not AI-modified
1 . A compound of formula (I) or a pharmaceutically acceptable salt thereof, 
       
         
           
           
               
               
           
         
         wherein 
         R 1  is hydrogen, CD2CD3, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, a C 3 -C 6  cycloalkyl, a phenyl, or a 5-6 membered monocyclic heteroaryl; wherein the C 3 -C 6  cycloalkyl, the phenyl, and the 5-6 membered monocyclic heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; 
         R 2  is G 2a , C 1 -C 6  haloalkyl, or C 1 -C 6  alkyl wherein the C 1 -C 6  alkyl is optionally substituted with one substituent selected from the group consisting of G 2b  and —OH;
 G 2a  is a phenyl or a C 3 -C 6  monocyclic cycloalkyl; wherein each G 2a  is optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; 
 G 2b  is phenyl optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; 
 
         R 3  is C 1 -C 6  haloalkyl, C 1 -C 6  alkyl, or a C 3 -C 6  monocyclic cycloalkyl wherein the C 3 -C 6  monocyclic cycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; or 
         R 2  and R 3 , together with the carbon atom to which they are attached, form a C 3 -C 6  monocyclic cycloalkyl, a C 4 -C 6  monocyclic cycloalkenyl, or a 4-6 membered monocyclic heterocycle; wherein the C 3 -C 6  monocyclic cycloalkyl, the C 4 -C 6  monocyclic cycloalkenyl, and the 4-6 membered monocyclic heterocycle are each optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; 
         R 4  is phenyl, pyridinyl, a C 3 -C 6  monocyclic cycloalkyl, or a C 4 -C 6  monocyclic cycloalkenyl; wherein each R 4  is optionally substituted with 1, 2, 3, or 4 independently selected R y  groups; or 
         R 4  is formula (a) 
       
       
         
           
           
               
               
           
         
         
           R 4a  and R 4b  are each independently halogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; 
           R 4c  and R 4d  are each independently hydrogen, halogen, —CN, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, —S(C 1 -C 6  alkyl), —S(O) 2 (C 1 -C 6  alkyl), or —(C 1 -C 6  alkylenyl)-OH; 
           Y is C(R 4e ) or N; wherein R 4e  is hydrogen, halogen, —CN, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; 
         
         R x , at each occurrence, is independently halogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; 
         R y , at each occurrence, is independently halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, —O(C 1 -C 6  alkyl), —O(C 1 -C 6  haloalkyl), or —(C 1 -C 6  alkylenyl)-OH; 
         X 1  and X 2  are C(R 5 ); or 
         one of X 1  and X 2  is N and the other is C(R 5 ); 
         R 5 , at each occurrence, is independently hydrogen or halogen; and 
         R 6  is hydrogen, halogen, —CN, C 1 -C 6  haloalkyl, or C 1 -C 6  alkyl. 
       
     
     
         2 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein
 R 1  is CD2CD3, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, or a C 3 -C 6  cycloalkyl; wherein the C 3 -C 6  cycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected R x  groups. 
 
     
     
         3 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein
 R 2  is phenyl, cyclopropyl, cyclopentyl, C 1 -C 6  haloalkyl, or C 1 -C 6  alkyl wherein the C 1 -C 6  alkyl is optionally substituted with one substituent selected from the group consisting of G 2b  and —OH; and wherein the phenyl, the cyclopropyl, and the cyclopentyl are each optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; and 
 R 3  is C 1 -C 6  haloalkyl, C 1 -C 6  alkyl, or a cyclopropyl wherein the cyclopropyl is optionally substituted with 1, 2, 3, or 4 independently selected R x  groups. 
 
     
     
         4 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein
 R 2  and R 3 , together with the carbon atom to which they are attached, form a C 3 -C 6  monocyclic cycloalkyl, a C 4 -C 6  monocyclic cycloalkenyl, or a 4-6 membered monocyclic heterocycle; wherein the C 3 -C 6  monocyclic cycloalkyl, the C 4 -C 6  monocyclic cycloalkenyl, and the 4-6 membered monocyclic heterocycle are each optionally substituted with 1, 2, 3, or 4 independently selected R x  groups. 
 
     
     
         5 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein
 R 4  is phenyl, pyridinyl, a C 3 -C 6  monocyclic cycloalkyl, or a C 4 -C 6  monocyclic cycloalkenyl; wherein each R 4  is optionally substituted with 1, 2, 3, or 4 independently selected R y  groups. 
 
     
     
         6 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein
 R 4  is formula (a) 
 
       
         
           
           
               
               
           
         
       
     
     
         7 . The compound of  claim 6  or a pharmaceutically acceptable salt thereof, wherein
 R 4a  is halogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; 
 R 4b  is halogen or C 1 -C 6  alkyl; 
 R 4d  is hydrogen or halogen; and 
 Y is C(R 4e ) or N; wherein R 4e  is hydrogen. 
 
     
     
         8 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein
 X 1  is N or C(R 5 ); 
 X 2  is C(R 5 ); and 
 R 5  is hydrogen. 
 
     
     
         9 . The compound of  claim 8  or a pharmaceutically acceptable salt thereof, wherein
 R 2  and R 3 , together with the carbon atom to which they are attached, form a C 3 -C 6  monocyclic cycloalkyl, a C 4 -C 6  monocyclic cycloalkenyl, or a 4-6 membered monocyclic heterocycle; wherein the C 3 -C 6  monocyclic cycloalkyl, the C 4 -C 6  monocyclic cycloalkenyl, and the 4-6 membered monocyclic heterocycle are each optionally substituted with 1, 2, 3, or 4 independently selected R x  groups. 
 
     
     
         10 . The compound of  claim 9  or a pharmaceutically acceptable salt thereof, wherein
 R 4  is formula (a); wherein
 R 4a  is halogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; 
 R 4b  is halogen or C 1 -C 6  alkyl; 
 R 4d  is hydrogen or halogen; and 
 Y is C(R 4e ) or N; wherein R 4e  is hydrogen; and 
 
 R 6  is hydrogen or halogen. 
 
     
     
         11 . The compound of  claim 8  or a pharmaceutically acceptable salt thereof, wherein
 R 2  is phenyl, cyclopropyl, cyclopentyl, C 1 -C 6  haloalkyl, or C 1 -C 6  alkyl wherein the C 1 -C 6  alkyl is optionally substituted with one substituent selected from the group consisting of G 2b  and —OH; and wherein the phenyl, the cyclopropyl, and the cyclopentyl are each optionally substituted with 1, 2, 3, or 4 independently selected R x  groups; and 
 R 3  is C 1 -C 6  haloalkyl, C 1 -C 6  alkyl, or a cyclopropyl wherein the cyclopropyl is optionally substituted with 1, 2, 3, or 4 independently selected R x  groups. 
 
     
     
         12 . The compound of  claim 11  or a pharmaceutically acceptable salt thereof, wherein
 R 4  is phenyl, pyridinyl, a C 3 -C 6  monocyclic cycloalkyl, or a C 4 -C 6  monocyclic cycloalkenyl; wherein each R 4  is optionally substituted with 1, 2, 3, or 4 independently selected R y  groups; and 
 R 6  is hydrogen. 
 
     
     
         13 . The compound of  claim 12  or a pharmaceutically acceptable salt thereof, wherein
 X 1  is C(R 5 ); 
 X 2  is C(R 5 ); 
 R 5  is hydrogen; and 
 R 1 , R 2 , and R 3  are C 1 -C 6  alkyl. 
 
     
     
         14 . The compound of  claim 11  or a pharmaceutically acceptable salt thereof, wherein
 R 4  is formula (a); and 
 R 6  is hydrogen or halogen. 
 
     
     
         15 . The compound of  claim 14  or a pharmaceutically acceptable salt thereof, wherein
 R 4a  is halogen, C 1 -C 6  alkyl, or C 1 -C 6  haloalkyl; 
 R 4b  is halogen or C 1 -C 6  alkyl; 
 R 4d  is hydrogen or halogen; and 
 Y is C(R 4e ) or N; wherein R 4e  is hydrogen. 
 
     
     
         16 . The compound of  claim 14  or a pharmaceutically acceptable salt thereof, wherein
 R 4a  is C 1 -C 3  alkyl; 
 R 4b  is C 1 -C 3  alkyl; 
 R 4c  is hydrogen or halogen; 
 R 4d  is hydrogen; and 
 Y is C(R 4e ) or N wherein R 4e  is hydrogen. 
 
     
     
         17 . The compound of  claim 16  or a pharmaceutically acceptable salt thereof, wherein
 R 2  is C 1 -C 6  haloalkyl or C 1 -C 6  alkyl wherein the C 1 -C 6  alkyl is optionally substituted with one —OH; and 
 R 3  is C 1 -C 6  haloalkyl or C 1 -C 6  alkyl. 
 
     
     
         18 . The compound of  claim 16  or a pharmaceutically acceptable salt thereof, wherein
 R 1 , R 2 , and R 3  are C 1 -C 6  alkyl; and 
 Y is C(R 4e ) wherein R 4e  is hydrogen. 
 
     
     
         19 . The compound of  claim 18  or a pharmaceutically acceptable salt thereof, wherein
 X 1  is C(R 5 ); 
 X 2  is C(R 5 ); and 
 R 5  is hydrogen. 
 
     
     
         20 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-I]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(3-hydroxypentan-3-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(1-hydroxycyclopent-3-en-1-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(1-hydroxycyclopent-3-en-1-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(1-hydroxycyclopentyl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(1-hydroxy-1-phenylpropyl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxybutan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-(2,6-dimethylphenoxy)-5-[1-(4-fluorophenyl)-1-hydroxypropyl]pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(3-hydroxy-5-methylhexan-3-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(1-cyclopentyl-1-hydroxypropyl)-2-(2,6-dimethylphenoxy)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(1-cyclopropyl-1-hydroxypropyl)-2-(2,6-dimethylphenoxy)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(3-hydroxy-4-methylhexan-3-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(3-hydroxy-1-phenylpentan-3-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-(2,6-dimethylphenoxy)-5-[1-(4-fluorophenyl)-2-hydroxybutan-2-yl]pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(1-hydroxy-1-phenylethyl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-(2,6-dimethylphenoxy)-5-[1-(4-fluorophenyl)-1-hydroxyethyl]pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxy-4-methylpentan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxy-3-methylbutan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxy-3-methylpentan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxy-4-phenylbutan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-(2,6-dimethylphenoxy)-5-[1-(4-fluorophenyl)-2-hydroxypropan-2-yl]pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-[cyclopropyl(4-fluorophenyl)hydroxymethyl]-2-(2,6-dimethylphenoxy)pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-[cyclopentyl(cyclopropyl)hydroxymethyl]-2-(2,6-dimethylphenoxy)pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-[dicyclopropyl(hydroxy)methyl]-2-(2,6-dimethylphenoxy)pyridin-3-yl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(1-cyclopropyl-1-hydroxy-2-methylpropyl)-2-(2,6-dimethylphenoxy)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(1-cyclopropyl-1-hydroxy-2-methylbutyl)-2-(2,6-dimethylphenoxy)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-{5-(2-hydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2′,4′-difluoro-4-(2-hydroxypropan-2-yl) [1,1′-biphenyl]-2-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(2,2-difluoro-1-methylcyclopropyl)-4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-(2,2-difluoro-1-methylcyclopropyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-[2,6-dimethyl-4-(methylsulfanyl)phenoxy]-5-(2-hydroxypropan-2-yl)phenyl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-(2,2-difluoro-1-methylcyclopropyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(2-hydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]pyridin-3-yl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-(2-hydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]pyridin-3-yl}-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(2,2-difluoro-1-methylcyclopropyl)-4-{5-(2-hydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]pyridin-3-yl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-{5-(2-hydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]pyridin-3-yl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(2-hydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-N-(1,1,1-trifluoro-2-methylpropan-2-yl)-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-(2,2-difluoro-1-methylcyclopropyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(2,2-difluoro-1-methylcyclopropyl)-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(2,2-difluoro-1-methylcyclopropyl)-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-(2,2-difluoro-1-methylcyclopropyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(bicyclo[1.1.1]pentan-1-yl)-4-[2-(2-chloro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-4-fluoro-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[4-fluoro-2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(1,2-dihydroxypropan-2-yl)-2-(2,6-dimethylphenoxy)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(2,4-dihydroxybutane-2-yl)-2-(2,6-dimethylphenoxy)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-[(2R)-1,2-dihydroxypropan-2-yl]-2-(2,6-dimethylphenoxy)phenyl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-[(2S)-1,2-dihydroxypropan-2-yl]-2-(2,6-dimethylphenoxy)phenyl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-[2-(difluoromethyl)-6-methylphenoxy]-5-(2-hydroxypropan-2-yl)phenyl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{2-[2-(difluoromethyl)-6-methylphenoxy]-5-(2-hydroxypropan-2-yl)phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-bromo-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-cyano-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-[(2,4-dimethylpyridin-3-yl)oxy]-5-(2-hydroxypropan-2-yl)phenyl}-N-ethyl-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(bicyclo[1.1.1]pentan-1-yl)-1-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[3-(2,6-dimethylphenoxy)-6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[3-(2,6-dimethylphenoxy)-6-(2-hydroxypropan-2-yl)pyridin-2-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-fluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(2-fluoro-6-methylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-(d 5 )ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-fluoro-2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-chloro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(methanesulfonyl)-2,6-dimethylphenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-fluoro-2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-chloro-2,6-dimethylphenoxy)-5-(1-fluoro-2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,4-difluorophenyl)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(methanesulfonyl)-2,6-dimethylphenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(3-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(methanesulfonyl)-2,6-dimethylphenoxy]pyridin-3-yl}-6-methyl-7-oxo-6, 7-dihydro-1H-pyrrolo[2, 3-c]pyridine-2-carboxamide; 
 N-ethyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(methanesulfonyl)-2,6-dimethylphenoxy]pyridin-3-yl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-chloro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(4-chloro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[3-(4-fluoro-2,6-dimethylphenoxy)-6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[3-(4-fluoro-2,6-dimethylphenoxy)-6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{2-[2-(difluoromethyl)-4-fluoro-6-methylphenoxy]-5-(2-hydroxypropan-2-yl)phenyl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(3-chloro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2,6-dichloro-4-fluorophenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dichloro-4-fluorophenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-chloro-2,6-dimethylphenoxy)-5-(1-fluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(4-chloro-2,6-dimethylphenoxy)-5-(1-fluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(3-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxy-4-methylpentan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxy-4-methylpentan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(2-hydroxypropan-2-yl)-2,6-dimethylphenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(2-hydroxypropan-2-yl)-2,6-dimethylphenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(3-chloro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)pyridin-3-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[4-(2-hydroxypropan-2-yl)-4′-(trifluoromethoxy)[1,1′-biphenyl]-2-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[4′,4′-difluoro-4-(2-hydroxypropan-2-yl)[2′,3′,4′,5′-tetrahydro[1,1′-biphenyl]]-2-yl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[4-(2-hydroxypropan-2-yl)-4′-methyl[2′,3′,4′,5′-tetrahydro[1,1′-biphenyl]]-2-yl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(cyclopent-1-en-1-yl)-5-(2-hydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-6-methylphenoxy)-5-(1,2-dihydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2-chloro-6-methylphenoxy)-5-(1,2-dihydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(1,2-dihydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(2-chloro-4-fluoro-6-methylphenoxy)-5-(1,2-dihydroxypropan-2-yl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-N,6-dimethyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-cyclopropyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(1-hydroxycyclobutyl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; and 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(3-hydroxyoxetan-3-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide. 
 
     
     
         21 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) according to  claim 1 , or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier. 
     
     
         22 . A method for treating cancer in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof. 
     
     
         23 . The method of  claim 22  wherein the cancer is selected from the group consisting of: acoustic neuroma, acute leukemia, acute lymphocytic leukemia, acute myelocytic leukemia (monocytic, myeloblastic, adenocarcinoma, angiosarcoma, astrocytoma, myelomonocytic and promyelocytic), acute t-cell leukemia, basal cell carcinoma, bile duct carcinoma, bladder cancer, brain cancer, breast cancer, bronchogenic carcinoma, cervical cancer, chondrosarcoma, chordoma, choriocarcinoma, chronic leukemia, chronic lymphocytic leukemia, chronic myelocytic (granulocytic) leukemia, chronic myelogenous leukemia, colon cancer, colorectal cancer, craniopharyngioma, cystadenocarcinoma, diffuse large B-cell lymphoma, dysproliferative changes (dysplasias and metaplasias), embryonal carcinoma, endometrial cancer, endotheliosarcoma, ependymoma, epithelial carcinoma, erythroleukemia, esophageal cancer, estrogen-receptor positive breast cancer, essential thrombocythemia, Ewing&#39;s tumor, fibrosarcoma, follicular lymphoma, germ cell testicular cancer, glioma, glioblastoma, gliosarcoma, heavy chain disease, hemangioblastoma, hepatoma, hepatocellular cancer, hormone insensitive prostate cancer, leiomyosarcoma, leukemia, liposarcoma, lung cancer, lymphagioendotheliosarcoma, lymphangiosarcoma, lymphoblastic leukemia, lymphoma (Hodgkin&#39;s and non-Hodgkin&#39;s), malignancies and hyperproliferative disorders of the bladder, breast, colon, lung, ovaries, pancreas, prostate, skin, and uterus, lymphoid malignancies of T-cell or B-cell origin, leukemia, lymphoma, medullary carcinoma, medulloblastoma, melanoma, meningioma, mesothelioma, multiple myeloma, myelogenous leukemia, myeloma, myxosarcoma, neuroblastoma, NUT midline carcinoma (NMC), non-small cell lung cancer, oligodendroglioma, oral cancer, osteogenic sarcoma, ovarian cancer, pancreatic cancer, papillary adenocarcinomas, papillary carcinoma, pinealoma, polycythemia vera, prostate cancer, rectal cancer, renal cell carcinoma, retinoblastoma, rhabdomyosarcoma, sarcoma, sebaceous gland carcinoma, seminoma, skin cancer, small cell lung carcinoma, solid tumors (carcinomas and sarcomas), small cell lung cancer, stomach cancer, squamous cell carcinoma, synovioma, sweat gland carcinoma, thyroid cancer, Waldenstrom&#39;s macroglobulinemia, testicular tumors, uterine cancer, and Wilms&#39; tumor. 
     
     
         24 . A method for treating a disease or condition in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said disease or condition is selected from the group consisting of Addison&#39;s disease, acute gout, ankylosing spondylitis, asthma, atherosclerosis, Behcet&#39;s disease, bullous skin diseases, chronic obstructive pulmonary disease (COPD), Crohn&#39;s disease, dermatitis, eczema, giant cell arteritis, glomerulonephritis, hepatitis, hypophysitis, inflammatory bowel disease, Kawasaki disease, lupus nephritis, multiple sclerosis, myocarditis, myositis, nephritis, organ transplant rejection, osteoarthritis, pancreatitis, pericarditis, polyarteritis nodosa, pneumonitis, primary biliary cirrhosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, scleritis, sclerosing cholangitis, sepsis, systemic lupus erythematosus, Takayasu&#39;s Arteritis, toxic shock, thyroiditis, type I diabetes, ulcerative colitis, uveitis, vitiligo, vasculitis, and Wegener&#39;s granulomatosis. 
     
     
         25 . A method for treating an acquired immunodeficiency syndrome (AIDS) in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof. 
     
     
         26 . A method for treating a disease or condition in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said disease or condition is selected from the group consisting of: obesity, dyslipidemia, hypercholesterolemia, Alzheimer&#39;s disease, metabolic syndrome, hepatic steatosis, type II diabetes, insulin resistance, diabetic retinopathy, and diabetic neuropathy. 
     
     
         27 . A method of contraception in a male subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof. 
     
     
         28 . A method for treating an acute kidney disease or condition in a subject comprising administering a therapeutically effective amount of a compound of  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said acute kidney disease or condition is selected from the group consisting of: ischemia-reperfusion induced kidney disease, cardiac and major surgery induced kidney disease, percutaneous coronary intervention induced kidney disease, radio-contrast agent induced kidney disease, sepsis induced kidney disease, pneumonia induced kidney disease, and drug toxicity induced kidney disease. 
     
     
         29 . A method of treating a chronic kidney disease or condition in a subject comprising administering a therapeutically effective amount of a compound of  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said chronic kidney disease or condition is selected from the group consisting of: diabetic nephropathy, hypertensive nephropathy, HIV-associated nephropathy, glomerulonephritis, lupus nephritis, IgA nephropathy, focal segmental glomerulosclerosis, membranous glomerulonephritis, minimal change disease, polycystic kidney disease and tubular interstitial nephritis. 
     
     
         30 . A process for preparing compounds of formula (A), wherein the process comprises bromination of compounds of formula (B) 
       
         
           
           
               
               
           
         
         wherein 
         PG 1  is a nitrogen protecting group; and 
         R 105  is C 1 -C 6  alkyl. 
       
     
     
         31 . The process of  claim 30  wherein PG 1  is selected from the group consisting of p-toluenesulfonyl, benzyl, and 2-(trimethylsilyl)ethoxymethyl. 
     
     
         32 . The process of  claim 30  wherein R 105  is ethyl. 
     
     
         33 . The process of  claim 30  wherein compound (B) is brominated using a brominating agent in the presence of an acid and with or without a solvent. 
     
     
         34 . The process of  claim 33  wherein the brominating agent is selected from the group consisting of bromine and N-bromosuccinimide. 
     
     
         35 . The process of  claim 33  wherein the acid is selected from the group consisting of p-toluenesulfonic acid and acetic acid. 
     
     
         36 . The process of  claim 33  wherein the solvent is selected from tetrahydrofuran and acetonitrile. 
     
     
         37 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of
 N-ethyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(2-hydroxypropan-2-yl)-2,6-dimethylphenoxy]pyridin-3-yl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(2-hydroxypropan-2-yl)-2-[4-(2-hydroxypropan-2-yl)-2,6-dimethylphenoxy]pyridin-3-yl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-{5-(1,2-dihydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]phenyl}-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 N-tert-butyl-4-{5-(1,2-dihydroxypropan-2-yl)-2-[2-methyl-6-(trifluoromethyl)phenoxy]phenyl}-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; 
 4-[5-(2,5-dihydroxypentane-2-yl)-2-(4-fluoro-2,6-dimethylphenoxy)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; and 
 N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(4-hydroxyoxan-4-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide.
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