System and method for localizing medical instruments during cardiovascular medical procedures

Abstract

A system and method for localizing medical instruments during cardiovascular medical procedures is described. One embodiment comprises an electromagnetic field generator; an antenna reference instrument adapted to be introduced into the heart of a subject and including at least one electromagnetic sensor and at least one electrode; at least one roving instrument adapted to be introduced into the thorax cavity of the subject and including at least one electrode; and a control unit configured to determine position coordinates of the antenna reference instrument based on an electromagnetic signal from the electromagnetic field generator sensed by the electromagnetic sensor, measure an electrical-potential difference between the electrode of the antenna reference instrument and the electrode of the roving instrument, and calibrate the measured electrical-potential difference using the determined position coordinates of the antenna reference instrument to determine position coordinates of the roving instrument.

1 .- 4 . (canceled) 
     
     
         5 . A position sensing system, comprising:
 a first localization field generator;   a second localization field generator;   an antenna reference instrument, a distal portion of the antenna reference instrument adapted to be introduced minimally invasively into a living coronary sinus of a beating heart of a subject, the distal portion of the antenna reference instrument including a first localization sensor compatible with the first field generator and a second localization sensor compatible with the second localization field generator, and having an adjustable deflection when located within the living coronary sinus;   a roving instrument adapted to be introduced into a thorax cavity of the subject, the roving instrument including a third localization sensor compatible with the second field generator; and   a control unit configured to:
 with the distal portion of the antenna reference instrument located within the living coronary sinus, determine position coordinates of the antenna reference instrument based on a signal from the first field generator sensed by the first localization sensor when the first localization sensor is disposed within the coronary sinus; 
 with the distal portion of the antenna reference instrument located within the living coronary sinus, measure a difference between the second localization sensor and the third localization sensor; and 
 with the distal portion of the antenna reference instrument located within the living coronary sinus, calibrate the measured difference using the determined position coordinates of the antenna reference instrument to determine position coordinates of the roving instrument. 
   
     
     
         6 . The position sensing system of  claim 5 , wherein the antenna reference instrument includes a catheter system designed for placement in and cannulation of the coronary sinus. 
     
     
         7 . The position sensing system of  claim 6 , wherein the catheter system has a usable length of 65-110 centimeters, a thickness of 5-7 French, and an adjustable deflection of 0-180 degrees, and wherein the catheter system includes 2-20 electrodes for sensing electrocardiograms and an integrated electromagnetic sensor that includes a metallic coil. 
     
     
         8 . The position sensing system of  claim 5 , wherein the antenna reference instrument includes at least one of a pacemaker or an implantable cardioverter defibrillator (“ICD”) lead system designed for placement in and cannulation of the coronary sinus. 
     
     
         9 . The position sensing system of  claim 8 , wherein at least one of the pacemaker or the ICD lead system has a usable length of 65-110 centimeters, a thickness of 5-7 French, and one of a fixed or an adjustable deflection of 0-180 degrees, and wherein at least one of the pacemaker and the ICD lead system includes 2-20 electrodes for sensing electrocardiograms and an integrated electromagnetic sensor that includes a metallic coil. 
     
     
         10 . The position sensing system of  claim 5 , wherein the control unit is configured to, with the distal portion of the antenna reference instrument located within the living coronary sinus, determine additional position coordinates of the antenna reference instrument based on electrical-potential sensed by the antenna reference instrument to provide redundant tracking of the antenna reference instrument. 
     
     
         11 . The position sensing system of  claim 5 , further comprising a monitor connected to the control unit, wherein the control unit is configured to:
 store multiple images of the heart from systole through diastole in a memory;   display, on the monitor and with the distal portion of the antenna reference instrument located within the living coronary sinus, a dynamic image of the heart corresponding to the heart's phase using the stored multiple images of the heart; and   display, on the monitor, a dynamic image of the at least one roving instrument showing the location of the at least one roving instrument with respect to the heart using the determined position coordinates of the at least one roving instrument.   
     
     
         12 . The position sensing system of  claim 5 , wherein the control unit includes:
 at least one central processing unit; and   at least two graphical processing units;   wherein the at least two graphical processing units are on separate graphics cards, and the control unit is configured to parallel process mathematical computations on the at least one central processing unit and the at least two graphical processing units.   
     
     
         13 . The position sensing system of  claim 5 , wherein the control unit is configured to:
 communicate via an application programming interface with a device, the device including at least one of an RF generator, an ultrasound imaging device, an esophageal temperature probe, or an electrocardiogram recording device;   retrieve information from the device; and   store the information in a memory.   
     
     
         14 . The position sensing system of  claim 5 , wherein the control unit is configured to:
 determine movement of the antenna reference instrument outside of a predetermined threshold to a new location when the distal portion of the antenna reference instrument is located within the living coronary sinus;   determine position coordinates of the antenna reference instrument at the new location based on sensing a signal from the first localization field generator using the first localization sensor when the first localization sensor is located within the living coronary sinus;   with the distal portion of the antenna reference instrument located within the living coronary sinus, measure a difference between the second localization sensor of the antenna reference instrument at the new location and the third localization sensor of the roving instrument;   with the distal portion of the antenna reference instrument located within the living coronary sinus, calibrate the measured difference using the determined position coordinates of the antenna reference instrument at the new location to determine position coordinates of the roving instrument; and   with the distal portion of the antenna reference instrument located within the living coronary sinus, apply the calibrated measured difference to previously recorded position coordinates of the roving instrument.   
     
     
         15 . A position sensing system, comprising:
 a first localization field generator;   a second localization field generator;   an antenna reference instrument, a distal portion of the antenna reference instrument being adapted to be introduced minimally invasively into a living coronary sinus of a heart of a subject, the distal portion of the antenna reference instrument including a first sensor compatible with the first field generator and a second sensor compatible with the second field generator, the distal portion of the antenna reference instrument having an adjustable deflection when located within the living coronary sinus;   a roving instrument adapted to be introduced into a cavity of the subject, the roving instrument including a third sensor compatible with the second field generator; and   a control unit configured to perform the following steps when the distal portion of the antenna reference instrument is disposed in the coronary sinus of the heart of the subject:
 determine first position coordinates of the antenna reference instrument based on a first signal sensed by the first sensor when the first sensor is disposed within the coronary sinus; 
 determine second position coordinates of the antenna reference instrument based on a second signal sensed by the first sensor when the first sensor is disposed within the coronary sinus; 
 identify a reference shift of the antenna reference instrument when a comparison of the first position coordinates to the second position coordinates exceeds a predefined threshold; 
 measure a difference between the second sensor of the antenna reference instrument and the third sensor of the roving instrument; and 
 in response to the identified reference shift, calibrate the measured difference using the determined second position coordinates of the antenna reference instrument to determine position coordinates of the roving instrument. 
   
     
     
         16 . The position sensing system of  claim 15 , wherein the antenna reference instrument includes a catheter system designed for placement in and cannulation of the coronary sinus. 
     
     
         17 . The position sensing system of  claim 16 , wherein the catheter system has a usable length of 65-110 centimeters, a thickness of 5-7 French, and an adjustable deflection of 0-180 degrees, and wherein the catheter system includes 2-20 electrodes for sensing electrocardiograms and an integrated electromagnetic sensor that includes a metallic coil. 
     
     
         18 . A position sensing system, comprising:
 a first localization field generator;   a second localization field generator;   an antenna reference instrument, a distal portion of the antenna reference instrument adapted to be introduced minimally invasively into a moving coronary sinus of a living heart of a subject, the distal portion of the antenna reference instrument including a first sensor compatible with the first field generator and a second sensor compatible with the second field generator, the distal portion of the antenna reference instrument having an adjustable deflection such that the first sensor and the second sensor are deflectable relative to each other;   at least one medical instrument adapted to be introduced into the thorax cavity of the subject, the at least one medical instrument including a third sensor compatible with the second field generator; and   a computerized control system configured to:
 with the distal portion of the antenna reference instrument disposed within the moving coronary sinus, determine first position coordinates of the antenna reference instrument based on a signal from the first field generator sensed by the first sensor when the first sensor is disposed within the moving coronary sinus; 
 with the distal portion of the antenna reference instrument disposed within the moving coronary sinus, determine second position coordinates of the antenna reference instrument based on signals sensed by the second sensor of the antenna reference instrument when the second sensor of the antenna reference instrument is disposed within the moving coronary sinus; 
 with the distal portion of the antenna reference instrument disposed within the moving coronary sinus, measure a difference between the second sensor and the third sensor; and 
 with the distal portion of the antenna reference instrument disposed within the moving coronary sinus, calculate the position of the medical instrument based on the measured difference and the first position coordinates. 
   
     
     
         19 . The position sensing system of  claim 18 , wherein the computerized control system is further configured to:
 with the distal portion of the antenna reference instrument disposed within the living coronary sinus, detect a reference shift of the antenna reference instrument to a new location based on the signal sensed by the first sensor;   with the distal portion of the antenna reference instrument disposed within the living coronary sinus, determine third position coordinates of the antenna reference instrument based on a signal from the first field generator sensed by the first sensor at the new location;   with the distal portion of the antenna reference instrument disposed within the living coronary sinus, calculate an offset between the first position coordinates and the third position coordinates;   with the distal portion of the antenna reference instrument disposed within the living coronary sinus, apply the offset to the calculated position of the medical instrument; and   with the distal portion of the antenna reference instrument disposed within the living coronary sinus, apply the offset to recorded position coordinates of the medical instrument.   
     
     
         20 . The position sensing system of  claim 18 , wherein the antenna reference instrument includes a pacemaker. 
     
     
         21 . The position sensing system of  claim 18 , wherein the antenna reference instrument includes an implantable cardioverter defibrillator lead.