Methods for the treatment of sialorrhea

Abstract

The present invention provides safe and effective methods for the treatment of sialorrhea (excessive drooling) by administering an effective amount of N-desethyloxybutynin, or an optical R- or S-isomer thereof or a pharmaceutically acceptable salt thereof.

1 - 10 . (canceled) 
     
     
         11 . An oral or buccal dosage form comprising a therapeutically effective amount of N-desethyloxybutynin, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
     
     
         12 . The oral or buccal dosage form of  claim 11 , wherein the N-desethyloxybutynin or a pharmaceutically acceptable salt thereof comprises (R)—N-desethyloxybutynin, (S)—N-desethyloxybutynin, pharmaceutically acceptable salts thereof, or a combination thereof. 
     
     
         13 . The oral or buccal dosage form of  claim 11 , wherein the N-desethyloxybutynin or pharmaceutically acceptable salt thereof is administered as an immediate release dosage form. 
     
     
         14 . The oral or buccal dosage form of  claim 11 , wherein the N-desethyloxybutynin or pharmaceutically acceptable salt thereof is administered as a controlled release dosage form. 
     
     
         15 . The oral or buccal dosage form of  claim 11 , wherein the N-desethyloxybutynin or pharmaceutically acceptable salt thereof is administered as an extended release dosage form. 
     
     
         16 . The oral or buccal dosage form of  claim 11 , wherein the amount of N-desethyloxybutynin or pharmaceutically acceptable salt thereof is from about 1 mg to about 100 mg. 
     
     
         17 . The oral or buccal dosage form of  claim 11 , where in the amount N-desethyloxybutynin or pharmaceutically acceptable salt thereof is from about 2 mg to about 30 mg. 
     
     
         18 . The oral or buccal dosage form of  claim 11 , wherein the N-desethyloxybutynin or pharmaceutically acceptable salt thereof is administered as an oral tablet, capsule, lozenge, cachet, troche, adhesive, liquid, solution, syrup, elixir, dispersion, suspension, granule or powder. 
     
     
         19 . The oral or buccal dosage form of  claim 11 , wherein the N-desethyloxybutynin or pharmaceutically acceptable salt thereof is administered in a composition that dissolves in the mouth, adheres to the gum or inside of the cheek, or is held sublingually.