Antimicrobial, disinfecting and wound healing compositions and methods for producing and using same

Abstract

The present invention relates to antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same. The compositions may comprise one or more of a peracid, a hydroperoxide, a bis(hydroperoxide), or an epoxide.

1 . A wound healing composition made by a method comprising:
 contacting a keto acid or a salt or anhydride thereof with an oxidizing agent while stirring and under conditions sufficient to produce one or more of a peroxyacid, and one or more of a hydroperoxide, a bis(hydroperoxide), or an epoxide.   
     
     
         2 .- 9 . (canceled) 
     
     
         10 . The composition of  claim 1 , wherein the oxidizing agent is selected from the group consisting of hydrogen peroxide, barium peroxide, sodium carbonate peroxide, potassium superoxide, and a mixture thereof. 
     
     
         11 . The composition of  claim 10 , wherein the oxidizing agent is hydrogen peroxide. 
     
     
         12 .- 15 . (canceled) 
     
     
         16 . The composition of  claim 1 , further comprising a magnesium salt. 
     
     
         17 . The composition of  claim 16 , wherein the magnesium salt is magnesium acetate tetrahydrate. 
     
     
         18 . A wound healing composition comprising a peroxyacid and a hydroperoxide. 
     
     
         19 . The composition of  claim 18 , wherein the hydroperoxide is hydrogen peroxide. 
     
     
         20 . The composition of  claim 18 , wherein the composition further comprises the parent carboxylic acid of the peroxyacid. 
     
     
         21 . The composition of  claim 18 , wherein the composition further comprises a (bis)hydroperoxide and an epoxide. 
     
     
         22 . The composition of  claim 18 , wherein the peroxyacid is peracetic acid. 
     
     
         23 . The composition of  claim 21 , wherein the bis(hydroperoxide) is 3,3-bis(hydroperoxy)butanoic acid. 
     
     
         24 . The composition of  claim 20 , wherein the peroxyacid is peracetic acid and the parent carboxylic acid is acetic acid. 
     
     
         25 . The composition of  claim 24 , wherein the composition further comprises methylhydroperoxide or hydroxymethyl hydroperoxide. 
     
     
         26 . The composition of  claim 25 , further comprising 5-hydroperoxy-5-methyl-1,2-dioxolan-3-one. 
     
     
         27 . The composition of  claim 18 , further comprising a magnesium salt. 
     
     
         28 . The composition of  claim 27 , wherein the magnesium salt is the magnesium salt of peracetic acid. 
     
     
         29 . A method for treating a wound infection in a subject comprising contacting the infected wound in the subject with a therapeutically effective amount of the composition of  claim 1 . 
     
     
         30 . The method of  claim 29 , wherein the infected wound is a surgical wound, battle wound, accidental wound, thermal burn wound, chemical burn wound, chronic wound, decubitus ulcer, foot ulcer, venous ulcer, laser treatment wound, sunburn, or an abrasion. 
     
     
         31 . The method of  claim 29 , wherein the infected wound is contacted with the composition once a day. 
     
     
         32 . The method of  claim 29 , wherein the composition is formulated as a gel, a liquid, lotion, skin patch, irrigation gel, a liquid, lotion, skin patch, a spray, application granules, or a combination thereof.