Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Abstract

Pharmaceutical compositions and methods for treating neurological disorders by administering same are provided. The compositions comprise dextromethorphan in combination with quinidine.

1 . A method for treating traumatic brain injury, the method comprising administering to a patient in need thereof dextromethorphan in combination with quinidine, wherein the amount of dextromethorphan administered comprises from about 20 mg/day to about 60 mg/day and wherein the amount of quinidine administered comprises from about 10 mg/day to about 30 mg/day with the proviso that the weight-to-weight ratio of dextromethorphan to quinidine is 1:0.75 or less of quinidine. 
     
     
         2 - 16 . (canceled) 
     
     
         17 . A method of treating pain associated with diabetic neuropathy, the method comprising administering to a patient in need thereof dextromethorphan in combination with quinidine, wherein the amount of dextromethorphan administered is 120 mg/day and wherein the amount of quinidine administered is 120 mg/day. 
     
     
         18 . A method of treating pain associated with diabetic neuropathy, the method comprising administering to a patient in need thereof dextromethorphan in combination with quinidine, wherein the amount of dextromethorphan administered is 90 mg/day and wherein the amount of quinidine administered is 90 mg/day.