Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant

Abstract

Disclosed are methods and devices for obtaining patent hemostasis at an access site on the radial artery by compressing the ulnar artery to increase radial artery flow. Also disclosed are methods and devices for obtaining patent hemostasis at an access site on the ulnar artery by compressing the radial artery to increase ulnar artery flow. The device comprises a band having at least two inflatable bladders, at least one inflatable bladder used for applying pressure to the ulnar artery. and at least one inflatable bladder used for applying pressure to the radial artery.

1 . A method of attaining patent hemostasis of an ulnar artery of a patient when performing a catheterization procedure at an access site of the ulnar artery, comprises performing the following steps:
 (a) applying a first pressure on a radial artery at a radial pressure site by compressing the radial artery partially or fully for a purpose of attaining patent hemostasis of the ulnar artery;   (b) applying a second pressure on the ulnar artery at the access site to stop bleeding at the access site;   (c) continuing to apply the second pressure on the ulnar artery for a duration of time to attain patent hemostasis of the ulnar artery;   (d) continuing to apply the first pressure on the radial artery at the radial pressure site to compress the radial artery partially or fully for a first period of time for the purpose of attaining patent hemostasis of the ulnar artery, wherein the first period of time is less than the duration of time to attain patent hemostasis of the ulnar artery; and   (e) attaining patent hemostasis of the ulnar artery;   wherein the first pressure is not applied on the radial artery for the purpose of attaining patent hemostasis of the ulnar artery for a second period of time up until and including the moment in which patent hemostasis of the ulnar artery is attained.   
     
     
         2 . The method of  claim 1 , wherein the duration of time in step (c) is less than 120 minutes. 
     
     
         3 . The method of  claim 1 , wherein the first period of time in step (d) is about 60 minutes. 
     
     
         4 . The method of  claim 1 , wherein the first pressure and the second pressure are applied using a band comprising at least two inflatable bladders. 
     
     
         5 . The method of  claim 1 , wherein step (a) precedes step (b). 
     
     
         6 . The method of  claim 1 , wherein step (b) precedes step (a). 
     
     
         7 . The method of  claim 1 , wherein the first pressure on the radial artery is reduced to zero after the first period of time. 
     
     
         8 . The method of  claim 1 , further comprising applying to the access site a composition comprising wound healing and/or hemostatic components. 
     
     
         9 . The method of  claim 8 , wherein the composition comprises chitosan. 
     
     
         10 . A method of obtaining hemostasis of an ulnar artery of a patient when performing a catheterization procedure at an access site of the ulnar artery, comprises performing the following steps:
 (a) administering a dose of an anticoagulant to the patient during the catheterization procedure;   (b) applying a hemostatic pressure to the ulnar artery at the access site for a duration of time to attain hemostasis of the ulnar artery;   (c) applying a radial pressure to a radial artery at a radial pressure site to fully compress the radial artery for a first period of time;   (d) applying a radial pressure to the radial artery at the radial pressure site to partially compress the radial artery for a second period of time; and   (e) attaining hemostasis of the ulnar artery;   wherein step (a) precedes all other steps.   
     
     
         11 . The method of  claim 10 , wherein step (c) precedes step (b). 
     
     
         12 . The method of  claim 10 , wherein the sum of first period of time in step (c) and the second period of time in step (d) is less than the duration of time in step (b). 
     
     
         13 . The method of  claim 10 , wherein the dose of the anticoagulant is less than an equivalent of 50 units of unfractionated heparin per kg of body weight. 
     
     
         14 . The method of  claim 10 , wherein the duration of time in step (b) is less than 120 minutes. 
     
     
         15 . The method of  claim 10 , wherein the radial pressure and the ulnar pressure are applied using a band comprising at least two inflatable bladders. 
     
     
         16 . The method of  claim 10 , wherein the anticoagulant is selected from a group consisting of: heparin, dalteparin, danaparoid, enoxaparin, unfractionated heparin, low molecular weight heparin, direct thrombin inhibitors including hirudin, argatroban, bivalirudin, and combinations or derivatives thereof. 
     
     
         17 . A method of attaining patent hemostasis of an ulnar artery of a patient when performing a catheterization procedure at an access site of the ulnar artery, comprises performing the following steps:
 (a) applying a patch or a dressing at the access site for a purpose of attaining patent hemostasis of the ulnar artery, said patch or said dressing comprising at least hemostatic materials;   (b) applying a first pressure on a radial artery at a radial pressure site by compressing the radial artery partially or fully for the purpose of attaining patent hemostasis of the ulnar artery;   (c) applying a second pressure on the ulnar artery at the access site to stop bleeding at the access site;   (d) continuing to apply the second pressure on the ulnar artery for a duration of time to attain patent hemostasis of the ulnar artery;   (e) continuing to apply the first pressure on the radial artery at the radial pressure site to compress the radial artery partially or fully;   (f) attaining patent hemostasis of the ulnar artery;   wherein the first pressure on the radial artery is applied for the purpose of attaining patent hemostasis of the ulnar artery at least until hemostasis of the ulnar artery.   
     
     
         18 . The method of  claim 18 , wherein the patch or the dressing in step (a) comprises chitosan. 
     
     
         19 . The method of  claim 18 , further comprising administering a dose of an anticoagulant to the patient during the catheterization procedure, the dose of the anticoagulant being less than an equivalent of 50 units of unfractionated heparin per kg of body weight. 
     
     
         20 . The method of  claim 10 , wherein the duration of time in step (d) is less than 120 minutes.