US2020291027A1PendingUtilityA1
Tetracyclic bromodomain inhibitors

Assignee: ABBVIE INCPriority: Mar 12, 2013Filed: Mar 23, 2020Published: Sep 17, 2020
Est. expiryMar 12, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Steven D. Fidanze Dachun Liu Robert A. Mantei Keith F. Mcdaniel John K. Pratt George S. Sheppard Le Wang Andrew Bogdan James H. Holms Justin D. Dietrich Jasmina Marjanovic Lisa A. Hasvold Yujia Dai
C07D 498/04C07D 471/16A61P 35/00C07D 471/22A61P 13/12C07D 498/14A61P 15/16A61P 31/18C07D 498/16
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References
Claims
Abstract

wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
Claims

exact text as granted — not AI-modified
1 . A compound of formula (I) or a pharmaceutically acceptable salt thereof, 
       
         
           
           
               
               
           
         
       
       wherein
 Y 1  is N or CH; 
 R 1  is CD3, C 1 -C 3  alkyl, or C 1 -C 3  haloalkyl; 
 R 2  is H or C 1 -C 3  alkyl; 
 Y 3  is N or CR 3 ; 
 R 3  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , —S(O)R 3d , —S(O) 2 R 3a , —S(O) 2 NR 3b R 3c , G 1 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —CN, —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , —C(O)N(R 3b )NR 3b R 3c , —S(O)R 3d , —S(O) 2 R 3a , —S(O) 2 NR 3b R 3c , —OR 3a , —OC(O)R 3d , —NR 3b R 3c , N(R 3b )C(O)R 3d , N(R 3b )SO 2 R 3d , N(R 3b )C(O)OR 3d , N(R 3b )C(O)NR 3b R 3c , N(R 3b )SO 2 NR 3b R 3c , and N(R 3b )C(NR 3b R 3c )═NR 3b R 3c ; 
 Y 2  is C(O), S(O) 2 , or CR 4 R 5 ; 
 R 4  is H, deuterium, C 1 -C 6  alkyl, halogen, or C 1 -C 6  haloalkyl; 
 R 5  is H, deuterium, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , S(O)R 5d , —S(O) 2 R 5a , —S(O) 2 NR 5b R 5c , or G 1 ; 
 wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —CN, —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , —C(O)N(R 5b )NR 5b R 5c , —S(O)R 5d , —S(O) 2 R 5a , —S(O) 2 NR 5b R 5 , —OR 5a , —OC(O)R 5d , —NR 5b R 5c , N(R 5b )C(O)R 5d , N(R 5b )SO 2 R 5d , N(R 5b )C(O)OR 5d , N(R 5b )C(O)NR 5b R 5d , N(R 5b )SO 2 NR 5b R 5c , and N(R 5b )C(NR 5b R 5c )═NR 5b R 5c ; 
 R 3a , R 3b , R 3c , R 5a , and R 5b , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6 alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , or —(C 1 -C 6  alkylenyl)-G 1 ; 
 R 5c , at each occurrence, is independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , —(C 1 -C 6  alkylenyl)-G 1 , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-OR a , or —(C 1 -C 6  alkylenyl)-C(O)OR a ; 
 R 3d , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , or —(C 1 -C 6  alkylenyl)-G 1 ; 
 R 5d , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , —(C 1 -C 6  alkylenyl)-G 1 , —(C 1 -C 6  alkylenyl)-NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ); 
 G 1 , at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 1  is optionally substituted with 1, 2, 3, 4, or 5 R 1g  groups; 
 R 6  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —S(O) 2 R 6a , —S(O) 2 NR 6b R 6c , or G 2 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 2 , —CN, —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —C(O)N(R 6b )NR 6b R 6c , —S(O)R 6d , —S(O) 2 R 6a , —S(O) 2 NR 6b R 6c , —OR 6a , —OC(O)R 6d , —NR 6b R 6c , N(R 6b )C(O)R 6d , N(R 6b )SO 2 R 6d , N(R 6b )C(O)OR 6d , N(R 6b )C(O)NR 6b R 6c , N(R 6b )SO 2 NR 6b R 6c , and N(R 6b )C(NR 6b R 6c )═NR 6b R 6c ; 
 R 6a , R 6b , and R 6c , at each occurrence, are each independently H, alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, haloalkyl, G 2 , —(C 1 -C 6  alkylenyl)-G 2 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 R 6d , at each occurrence, is independently alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, haloalkyl, G 2 , —(C 1 -C 6  alkylenyl)-G 2 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 G 2 , at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 2  is optionally substituted with 1, 2, 3, 4, or 5 R 2g  groups; 
 A 1  is C(R 7 ) or N; A 2  is C(R 8 ) or N; A 3  is C(R 9 ) or N; and A 4  is C(R 10 ) or N; wherein zero, one, or two of A 1 , A 2 , A 3 , and A 4  are N; 
 R 7 , R 8 , and R 9 , are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , —OR y1 , —OC(O)R y2 , —OC(O)NR y3 R y4 , —SR y1 , —S(O) 2 R y1 , —S(O) 2 NR y3 R y4 , —C(O)R y1 , —C(O)OR y1 , —C(O)NR y3 R y4 , —NR y3 R y4 , —N(R y3 )C(O)R y2 , —N(R y3 )S(O) 2 R y2 , —N(R y3 )C(O)O(R y2 ), —N(R y3 )C(O)NR y3 R y4 , —N(R y3 )S(O) 2 NR 3 R y4 , G 3 , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-OR y1 , —(C 1 -C 6  alkylenyl)-OC(O)R 2 , —(C 1 -C 6  alkylenyl)-OC(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-C(O)R 1 , —(C 1 -C 6  alkylenyl)-C(O)OR 1 , —(C 1 -C 6  alkylenyl)-C(O)NR y3 R 4 , —(C 1 -C 6  alkylenyl)-NR y3 R 4 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)O(R y2 ), —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-CN, or —(C 1 -C 6  alkylenyl)-G 3 ; 
 R y1 , R y3 , and R y4 , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 3 , —(C 1 -C 6  alkylenyl)-G 3 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e ) S(O) 2 NR c R d ; 
 R y2 , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 3 , —(C 1 -C 6  alkylenyl)-G 3 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 G 3 , at each occurrence, is independently aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocycle; and each G 3  group is optionally substituted with 1, 2, 3, 4, or 5 R 4g  groups; 
 R 10  is H, C 1 -C 3  alkyl, halogen, C 1 -C 3  haloalkyl, or —CN; 
 R 1g , R 2g , and R 4 , at each occurrence, is independently selected from the group consisting of oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , G 2a , —OR a , —OC(O)R b , —OC(O)NR c R d , —SR a , —S(O) 2 R a , —S(O) 2 NR c R d , —C(O)R a , —C(O)OR a , —C(O)NR c R d , —NR c R d , —N(R e )C(O)R b , —N(R e )S(O) 2 R b , —N(R e )C(O)O(R b ), —N(R e )C(O)NR c R d , —N(R e )S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-G 2a , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-OC(O)R b , —(C 1 -C 6  alkylenyl)-OC(O)NR c R d , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d , or —(C 1 -C 6  alkylenyl)-CN; 
 R a , R c , R d , and R e , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 2a , —(C 1 -C 6  alkylenyl)-OR z1 , —(C 1 -C 6  alkylenyl)-NR z3 R z4 , —(C 1 -C 6  alkylenyl)-C(O)NR z3 R z4 , or —(C 1 -C 6  alkylenyl)-G 2 a; 
 R b , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 2a , or —(C 1 -C 6  alkylenyl)-G 2a ; 
 G 2a , at each occurrence, are each independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 2a  group is optionally substituted with 1, 2, 3, 4, or 5 R 3g  groups; 
 R 3g , at each occurrence, is independently oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , —OR z1 , —OC(O)R z2 , —OC(O)NR z3 R z4 , —SR z1 , —S(O) 2 R z1 , —S(O) 2 NR z3 R z4 , —C(O)R z1 , —C(O)OR z1 , —C(O)NR z3 R z4 —NR z3 R z4 , —N(R z3 )C(O)R z2 , —N(R 3 )S(O) 2 R z2 , —N(R z3 )C(O)O(R z2 ), —N(R z3 )C(O)NR z3 R z4 , —N(R z3 )S(O) 2 NR 3 R 4 , —(C 1 -C 6  alkylenyl)-OR z1 , —(C 1 -C 6  alkylenyl)-OC(O)R z2 , —(C 1 -C 6  alkylenyl)-OC(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R z1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR z3 R z4 , —(C 1 -C 6  alkylenyl)-C(O)R z1 , —(C 1 -C 6  alkylenyl)-C(O)OR z1 , —(C 1 -C 6  alkylenyl)-C(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-NR z3 R z4 , —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)R z2 , —(C 1 -C 6  alkylenyl)-N(R z3 )S(O) 2 R z2 , —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)O(R 2 ), —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-N(R z3 )S(O) 2 NR 3 R 4 , or —(C 1 -C 6  alkylenyl)-CN; 
 R z1 , R z3 , and R z4 , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, or C 1 -C 6  haloalkyl; and 
 R z2 , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, or C 1 -C 6  haloalkyl. 
 
     
     
         2 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1  is C 1 -C 3  alkyl. 
     
     
         3 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 2  is H. 
     
     
         4 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein
 Y 1  is CH;   Y 3  is CR 3 ; and   Y 2  is CR 4 R 5 .   
     
     
         5 . The compound of  claim 4 , or a pharmaceutically acceptable salt thereof, wherein R 3  is H, —CN, —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , or C 1 -C 6  alkyl, wherein the C 1 -C 6  alkyl is optionally substituted with a substituent selected from the group consisting of G 1 , —NR 3b R 3c , N(R 3b )C(O)R 3d , N(R 3b )SO 2 R 3d , N(R 3b )C(O)OR 3d , N(R 3b )C(O)NR 3b R 3c , and N(R 3b )SO 2 NR 3b R 3c . 
     
     
         6 . The compound of  claim 4 , or a pharmaceutically acceptable salt thereof, wherein
 R 4  is H or deuterium; and   R 5  is H, deuterium, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, —C(O)R 5a , —C(O)OR 5a , or G 1 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , —C(O)N(R 5b )NR 5b R 5c , —OR 5a , —OC(O)R 5d , —NR 5b R 5c , N(R 5b )C(O)R 5d , N(R 5b )SO 2 R 5d , N(R 5b )C(O)OR 5d , N(R 5b )C(O)NR 5b R 5c , and N(R 5b )SO 2 NR 5b R 5c .   
     
     
         7 . The compound of  claim 4 , or a pharmaceutically acceptable salt thereof, wherein
 R 6  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —S(O) 2 R 6a , or G 2 ; wherein the C 1 -C 6  alkyl and the C 2 -C 6  alkenyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 2 , —CN, —C(O)OR 6a , —NR 6b R 6c , N(R 6b )C(O)R 6d , N(R 6b )SO 2 R 6d , N(R 6b )C(O)OR 6d , N(R 6b )C(O)NR 6b R 6c , and N(R 6b )SO 2 NR 6b R 6c .   
     
     
         8 . The compound of  claim 4 , or a pharmaceutically acceptable salt thereof, wherein
 A 1  is C(R 7 ), A 2  is C(R 8 ), A 3  is C(R 9 ), and A 4  is C(R 10 ); or   A 1  is N, A 2  is C(R 8 ), A 3  is C(R 9 ), and A 4  is C(R 10 ); or   A 1  is N, A 2  is C(R 8 ), A 3  is N, and A 4  is C(R 10 ).   
     
     
         9 . The compound of  claim 4 , or a pharmaceutically acceptable salt thereof, wherein
 R 9  is H, C 1 -C 6  alkyl, halogen, C 1 -C 6  haloalkyl, —CN, —S(O) 2 R y1 , —S(O) 2 NR y3 R 4 , —C(O)NR y3 R y4 , —NR y3 R y4 , —N(R y3 )C(O)R y2 , —N(R y3 )S(O) 2 R y2 , —N(R y3 )C(O)O(R y2 ), —N(R y3 )C(O)NR y3 R y4 , —N(R y3 )S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-C(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-NR y3 R y4 , —(C 1 -C 6  alkylenyl)-N(R 3 )C(O)R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)O(R y2 ), —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)NR y3 R y4 , or —(C 1 -C 6  alkylenyl)-N(R 3 )S(O) 2 NR y3 R 4 .   
     
     
         10 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein
 R 1  is C 1 -C 3  alkyl;   R 2  is H;   Y 1  is CH;   Y 3  is CR 3 ; and   Y 2  is CR 4 R 5 .   
     
     
         11 . The compound of  claim 10 , or a pharmaceutically acceptable salt thereof, wherein
 R 4  is H or deuterium; and   R 5  is C 2 -C 6  alkenyl optionally substituted with a G 1  group, or R 5  is H, deuterium, C 1 -C 6  alkyl, —C(O)R 5a , —C(O)OR 5a , or G 1 ; wherein the C 1 -C 6  alkyl is unsubstituted or substituted with a substituent selected from the group consisting of G 1 , —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , —C(O)N(R 5b )NR 5b R 5c , —OR 5a , —OC(O)R 5d , —NR 5b R 5c , and N(R 5b )C(NR 5b R 5c )═NR 5b R 5c .   
     
     
         12 . The compound of  claim 10 , or a pharmaceutically acceptable salt thereof, wherein
 R 3  is H, —C(O)R 3a , or —C(O)NR 3b R 3c .   
     
     
         13 . The compound of  claim 10 , or a pharmaceutically acceptable salt thereof, wherein
 R 6  is H, C 1 -C 6  alkyl, —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —S(O) 2 R 6a , or G 2 ; wherein the C 1 -C 6  alkyl is unsubstituted or substituted with a substituent selected from the group consisting of G 2  and —C(O)OR 6a .   
     
     
         14 . The compound of  claim 10 , or a pharmaceutically acceptable salt thereof, wherein
 R 9  is H, C 1 -C 6  alkyl, halogen, —S(O) 2 R y1 , —S(O) 2 NR y3 R y4 , —NR y3 R y4 , —N(R y3 )S(O) 2 R y2 , or —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 .   
     
     
         15 . The compound of  claim 10 , or a pharmaceutically acceptable salt thereof, wherein
 A 1  is C(R 7 ), A 2  is C(R 8 ), A 3  is C(R 9 ), and A 4  is C(R 10 ); or   A 1  is N, A 2  is C(R 8 ), A 3  is C(R 9 ), and A 4  is C(R 10 ); or   A 1  is N, A 2  is C(R 8 ), A 3  is N, and A 4  is C(R 10 ).   
     
     
         16 . The compound of  claim 15 , or a pharmaceutically acceptable salt thereof, wherein
 R 1  is methyl;   R 4  is H or deuterium;   R 7  is H, halogen, C 1 -C 3  alkyl, or optionally substituted cyclopropyl;   R 8  is H, C 1 -C 6  alkyl, halogen, C 1 -C 6  haloalkyl, —CN, optionally substituted heterocycle, —C(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-NR y3 R y4 , —(C 1 -C 6  alkylenyl)-N(R 3 )C(O)R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 R y2 , —(C 1 -C 6  alkylenyl)-N(R 3 )C(O)O(R y2 ), —(C 1 -C 6  alkylenyl)-N(R 3 )C(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 NR y3 R y4 , or —(C 1 -C 6  alkylenyl)-G 3  wherein G 3  is optionally substituted heterocycle; and   R 10  is H, C 1 -C 3  alkyl, or halogen.   
     
     
         17 . The compound of  claim 16 , or a pharmaceutically acceptable salt thereof, wherein
 R 3  is H or —C(O)NR 3b R 3c .   
     
     
         18 . The compound of  claim 16 , or a pharmaceutically acceptable salt thereof, wherein
 R 5  is H, deuterium, or C 1 -C 6  alkyl optionally substituted with a substituent selected from the group consisting of —C(O)OR 5a  and OR 5a .   
     
     
         19 . The compound of  claim 16 , or a pharmaceutically acceptable salt thereof, wherein
 R 6  is —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , G 2 , or C 1 -C 6  alkyl which is unsubstituted or substituted with a G 2  group.   
     
     
         20 . The compound of  claim 16 , or a pharmaceutically acceptable salt thereof, wherein
 R 9  is halogen, —NR y3 R y4 , —N(R y3 )C(O)R y2 , —N(R y3 )S(O) 2 R y2 , or —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 .   
     
     
         21 . The compound of  claim 16 , or a pharmaceutically acceptable salt thereof, wherein
 R 7  is H or halogen;   R 8  is H; and   R 10  is H.   
     
     
         22 . The compound of  claim 21 , or a pharmaceutically acceptable salt thereof, wherein
 R 9  is halogen, —N(R y3 )S(O) 2 R y2 , or —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 .   
     
     
         23 . The compound of  claim 22 , or a pharmaceutically acceptable salt thereof, wherein
 R 6  is —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , G 2 , or C 1 -C 6  alkyl which is unsubstituted or substituted with a G 2  group.   
     
     
         24 . The compound of  claim 23 , or a pharmaceutically acceptable salt thereof, wherein
 R 5  is H, deuterium, or C 1 -C 6  alkyl optionally substituted with a substituent selected from the group consisting of —C(O)OR 5a  and OR 5a .   
     
     
         25 . The compound of  claim 24 , or a pharmaceutically acceptable salt thereof, wherein
 R 3  is H or —C(O)NR 3b R 3c .   
     
     
         26 . The compound of  claim 25 , or a pharmaceutically acceptable salt thereof, wherein
 R 3b  and R 3c  are each independently H or C 1 -C 6  alkyl;   R 5a  is C 1 -C 6  alkyl;   R y1  and R y2  are C 1 -C 6  alkyl; and   R y3  is H.   
     
     
         27 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein
 A 1  is C(R 7 ), A 2  is C(R 8 ), A 3  is C(R 9 ), and A 4  is C(R 10 ).   
     
     
         28 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein
 A 1  is N, A 2  is C(R 8 ), A 3  is C(R 9 ), and A 4  is C(R 10 ).   
     
     
         29 . The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein
 A 1  is N, A 2  is C(R 8 ), A 3  is N, and A 4  is C(R 10 ).   
     
     
         30 . The compound of  claim 15 , or a pharmaceutically acceptable salt thereof, wherein
 R 1  is methyl;   R 3  is H, —C(O)NR 3b R 3c , —CN, or C 1 -C 6  alkyl which is substituted with a G 1  group;
 wherein G 1  is an optionally substituted C 4 -C 6  heterocycle; 
   R 4  is H or deuterium;   R 7  is H, halogen, —CN, C 1 -C 3  alkyl, or optionally substituted cyclopropyl;   R 8  is H;   R 9  is halogen, —N(R y3 )S(O) 2 R y2 , or —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 ; and   R 10  is H.   
     
     
         31 . The compound of  claim 30 , or a pharmaceutically acceptable salt thereof, wherein
 R 5  is H; and   R 6  is phenyl, pyridinyl, or cyclohexyl; each of which is optionally substituted; or R 6  is —C(O)O(C 1 -C 6  alkyl); or R 6  is —CH 2 — (optionally substituted tetrahydropyranyl).   
     
     
         32 . The compound of  claim 15 , or a pharmaceutically acceptable salt thereof, wherein
 R 1  is methyl;   R 3  is G 1 ;   R 4  is H or deuterium;   R 7  is H, halogen, —CN, C 1 -C 3  alkyl, or optionally substituted cyclopropyl;   R 8  is H;   R 9  is —S(O) 2 R y1 , —N(R y3 )S(O) 2 R y2 , or —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 ; and   R 10  is H.   
     
     
         33 . The compound of  claim 15 , or a pharmaceutically acceptable salt thereof, wherein
 R 1  is methyl;   R 3  is G 1 ; wherein G 1  is optionally substituted heteroaryl;   R 4  is H or deuterium;   R 7  is H, halogen, —CN, C 1 -C 3  alkyl, or optionally substituted cyclopropyl;   R 8  is H;   R 9  is —S(O) 2 R y1 , —N(R y3 )S(O) 2 R y2 , or —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 ;   R 10  is H; and   R 5  is H.   
     
     
         34 . A compound of formula (I) or a pharmaceutically acceptable salt thereof, 
       
         
           
           
               
               
           
         
       
       wherein
 Y 1  is N orCH; 
 R 1  is CD3, C 1 -C 3  alkyl, or C 1 -C 3  haloalkyl; 
 R 2  is H or C 1 -C 3  alkyl; 
 Y 3  is N or CR 3 ; 
 R 3  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , —S(O)R 3d , —S(O) 2 R 3a , —S(O) 2 NR 3b R 3c , Or G; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , —C(O)N(R 3b )NR 3b R 3c , —S(O)R 3d , —S(O) 2 R 3a , —S(O) 2 NR 3b R 3c , —OR 3a , —OC(O)R 3d , —NR 3b R 3c , N(R 3b )C(O)R 3d , N(R 3b )SO 2 R 3d , N(R 3b )C(O)OR 3d , N(R 3b )C(O)NR 3b R 3c  N(R 3b )SO 2 NR 3b R 3c , and N(R 3b )C(NR 3b R 3c )═NR 3b R 3c ; 
 Y 2  is C(O), S(O) 2 , or CR 4 R 5 ; 
 R 4  is H, deuterium, C 1 -C 6  alkyl, halogen, or C 1 -C 6  haloalkyl; 
 R 5  is H, deuterium, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , S(O)R 5d , —S(O) 2 R 5a , —S(O) 2 NR 5b R 5c , or G 1 ; 
 wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , —C(O)N(R 5b )NR 5b R 5c , —S(O)R 5d , —S(O) 2 R 5a , —S(O) 2 NR 5b R 5c , —OR 5a , —OC(O)R 5d , —NR 5b R 5c , N(R 5b )C(O)R 5d , N(R 5b )SO 2 R 5d , N(R 5b )C(O)OR 5d , N(R 5b )C(O)NR 5b R 5c , N(R 5b )SO 2 NR 5b R 5c , and N(R 5b )C(NR 5b R 5c )═NR 5b R 5c ; 
 R 3a , R 3b , R 3c , R 5a , R 5b , and R 5c , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , or —(C 1 -C 6  alkylenyl)-G 1 ; 
 R 3d  and R 5d , at each occurrence, are each independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , or —(C 1 -C 6  alkylenyl)-G 1 ; 
 G 1 , at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 1  is optionally substituted with 1, 2, 3, 4, or 5 R 1g  groups; 
 R 6  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —S(O) 2 R 6a , —S(O) 2 NR 6b R 6c , or G 2 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 2 , —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —C(O)N(R 6b )NR 6b R 6c , —S(O)R 6d , —S(O) 2 R 6a , —S(O) 2 NR 6b R 6c , —OR 6a , —OC(O)R 6d , —NR 6b R 6c , N(R 6b )C(O)R 6d , N(R 6b )SO 2 R 6d , N(R 6b )C(O)OR 6d , N(R 6b )C(O)NR 6b R 6c , N(R 6b )SO 2 NR 6b R 6c , and N(R 6b )C(NR 6b R 6c )═NR 6b R 6c ; 
 R 6a , R 6b , and R 6c , at each occurrence, are each independently H, alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, haloalkyl, G 2 , —(C 1 -C 6  alkylenyl)-G 2 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 R 6d , at each occurrence, is independently alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, haloalkyl, G 2 , —(C 1 -C 6  alkylenyl)-G 2 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 G 2 , at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 2  is optionally substituted with 1, 2, 3, 4, or 5 R 2g  groups; 
 A 1  is C(R 7 ) or N; A 2  is C(R 8 ) or N; A 3  is C(R 9 ) or N; and A 4  is C(R 10 ) or N; wherein zero, one, or two of A 1 , A 2 , A 3 , and A 4  are N; 
 R 7 , R 8 , and R 9 , are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , —OR y1 , —OC(O)R y2 , —OC(O)NR y3 R y4 , —SR y1 , —S(O) 2 R 1, —S(O) 2 NR y3 R y4 , —C(O)R y1 , —C(O)OR y1 , —C(O)NR y3 R y4 , —NR y3 R y4 , —N(R y3 )C(O)R y2 , —N(R y3 )S(O) 2 R y2 , —N(R y3 )C(O)O(R y2 ), —N(R y3 )C(O)NR y3 R y4 , —N(R y3 )S(O) 2 NR 3 R y4 , G 3 , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-OR y1 , —(C 1 -C 6  alkylenyl)-OC(O)R 2 , —(C 1 -C 6  alkylenyl)-OC(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-C(O)R 1 , —(C 1 -C 6  alkylenyl)-C(O)OR 1 , —(C 1 -C 6  alkylenyl)-C(O)NR y3 R 4 , —(C 1 -C 6  alkylenyl)-NR y3 R 4 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)O(R y2 ), —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-CN, or —(C 1 -C 6  alkylenyl)-G 3 ; 
 R y1 , R y3 , and R y4 , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 3 , —(C 1 -C 6  alkylenyl)-G 3 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e ) S(O) 2 NR c R d ; 
 R y2 , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 3 , —(C 1 -C 6  alkylenyl)-G 3 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 G 3 , at each occurrence, is independently aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocycle; and each G 3  group is optionally substituted with 1, 2, 3, 4, or 5 R 4g  groups; 
 R 10  is H, C 1 -C 3  alkyl, halogen, C 1 -C 3  haloalkyl, or —CN; 
 R 1g , R 2g , and R 4 , at each occurrence, is independently selected from the group consisting of oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , G 2a , —OR a , —OC(O)R b , —OC(O)NR c R d , —SR a , —S(O) 2 R a , —S(O) 2 NR c R d , —C(O)R a , —C(O)OR a , —C(O)NR c R d , —NR c R d , —N(R e )C(O)R b , —N(R e )S(O) 2 R b , —N(R e )C(O)O(R b ), —N(R e )C(O)NR c R d , —N(R e )S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-G 2a , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-OC(O)R b , —(C 1 -C 6  alkylenyl)-OC(O)NR c R d , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d , or —(C 1 -C 6  alkylenyl)-CN; 
 R a , R c , R d , and R e , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 2a , or —(C 1 -C 6  alkylenyl)-G 2a ; 
 R b , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 2a , or —(C 1 -C 6  alkylenyl)-G 2a ; 
 G 2a , at each occurrence, are each independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 2a  group is optionally substituted with 1, 2, 3, 4, or 5 R 3g  groups; 
 R 3g , at each occurrence, is independently oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , —OR z1 , —OC(O)R z2 , —OC(O)NR z3 R z4 , —SR z1 , —S(O) 2 R z1 , —S(O) 2 NR z3 R z4 , —C(O)R z1 , —C(O)OR z1 , —C(O)NR z3 R z4 , —NR z3 R z4 , —N(R z3 )C(O)R z2 , —N(R 3 )S(O) 2 R 2 , —N(R z3 )C(O)O(R z2 ), —N(R z3 )C(O)NR z3 R z4 , —N(R z3 )S(O) 2 NR 3 R 4 , —(C 1 -C 6  alkylenyl)-OR z1 , —(C 1 -C 6  alkylenyl)-OC(O)R z2 , —(C 1 -C 6  alkylenyl)-OC(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R z1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR z3 R z4 , —(C 1 -C 6  alkylenyl)-C(O)R z1 , —(C 1 -C 6  alkylenyl)-C(O)OR z1 , —(C 1 -C 6  alkylenyl)-C(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-NR z3 R z4 , —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)R z2 , —(C 1 -C 6  alkylenyl)-N(R z3 )S(O) 2 R z2 , —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)O(R 2 ), —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-N(R z3 )S(O) 2 NR 3 R 4 , or —(C 1 -C 6  alkylenyl)-CN; 
 R z1 , R z3 , and R z4 , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, or C 1 -C 6  haloalkyl; and 
 R z2 , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, or C 1 -C 6  haloalkyl. 
 
     
     
         35 . A compound of formula (I) or a pharmaceutically acceptable salt thereof, 
       
         
           
           
               
               
           
         
       
       wherein
 Y 1  is N or CH; 
 R 1  is CD3, C 1 -C 3  alkyl, or C 1 -C 3  haloalkyl; 
 R 2  is H or C 1 -C 3  alkyl; 
 Y 3  is N or CR 3 ; 
 R 3  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , —S(O)R 3d , —S(O) 2 R 3a , —S(O) 2 NR 3b R 3c , or G 1 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —CN, —C(O)R 3a , —C(O)OR 3a , —C(O)NR 3b R 3c , —C(O)N(R 3b )NR 3b R 3c , —S(O)R 3d , —S(O) 2 R 3a , —S(O) 2 NR 3b R 3c , —OR 3a , —OC(O)R 3d , —NR 3b R 3c , N(R 3b )C(O)R 3d , N(R 3b )SO 2 R 3d , N(R 3b )C(O)OR 3d , N(R 3b )C(O)NR 3b R 3c , N(R 3b )SO 2 NR 3b R 3c , and N(R 3b )C(NR 3b R 3c )═NR 3b R 3c ; 
 Y 2  is C(O), S(O) 2 , or CR 4 R 5 ; 
 R 4  is H, deuterium, C 1 -C 6  alkyl, halogen, or C 1 -C 6  haloalkyl; 
 R 5  is H, deuterium, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , S(O)R 5d , —S(O) 2 R a , —S(O) 2 NR 5b R 5c , or G 1 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 1 , —C(O)R 5a , —C(O)OR 5a , —C(O)NR 5b R 5c , —C(O)N(R 5b )NR 5b R 5c , —S(O)R 5d , —S(O) 2 R 5a , —S(O) 2 NR 5b R 5c , —OR 5a , —OC(O)R 5d , —NR 5b R 5c , N(R 5b )C(O)R 5d , N(R 5b )SO 2 R 5d , N(R 5b )C(O)OR 5d , N(R 5b )C(O)NR 5b R 5c , N(R 5b )SO 2 NR 5b R 5c , and N(R 5b )C(NR 5b R 5c )═NR 5b R 5c ; 
 R 3a , R 3b , R 3c , R 5a , and R 5b , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6 alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , or —(C 1 -C 6  alkylenyl)-G 1 ; 
 R 5c , at each occurrence, is independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , —(C 1 -C 6  alkylenyl)-G 1 , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-OR a , or —(C 1 -C 6  alkylenyl)-C(O)OR a ; 
 R 3d , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , or —(C 1 -C 6  alkylenyl)-G 1 ; 
 R 5d , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 1 , —(C 1 -C 6  alkylenyl)-G 1 , —(C 1 -C 6  alkylenyl)-NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ); 
 G 1 , at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each Gi is optionally substituted with 1, 2, 3, 4, or 5 R 1g  groups; 
 R 6  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —S(O) 2 R 6a , —S(O) 2 NR 6b R 6c , or G 2 ; wherein the C 1 -C 6  alkyl, C 2 -C 6  alkenyl, and C 2 -C 6  alkynyl are each independently unsubstituted or substituted with 1 or 2 substituents independently selected from the group consisting of G 2 , —C(O)R 6a , —C(O)OR 6a , —C(O)NR 6b R 6c , —C(O)N(R 6b )NR 6b R 6c , —S(O)R 6d , —S(O) 2 R 6a , —S(O) 2 NR 6b R 6c , —OR 6a , —OC(O)R 6d , —NR 6b R 6c , N(R 6b )C(O)R 6d , N(R 6b )SO 2 R 6d , N(R 6b )C(O)OR 6d , N(R 6b )C(O)NR 6b R 6c , N(R 6b )SO 2 NR 6b R 6c , and N(R 6b )C(NR 6b R 6c )═NR 6b R 6c ; 
 R 6a , R 6b , and R 6c , at each occurrence, are each independently H, alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, haloalkyl, G 2 , —(C 1 -C 6  alkylenyl)-G 2 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 R 6d , at each occurrence, is independently alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, haloalkyl, G 2 , —(C 1 -C 6  alkylenyl)-G 2 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 G 2 , at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 2  is optionally substituted with 1, 2, 3, 4, or 5 R 2g  groups; 
 A 1  is C(R 7 ) or N; A 2  is C(R 8 ) or N; A 3  is C(R 9 ) or N; and A 4  is C(R 10 ) or N; wherein zero, one, or two of A 1 , A 2 , A 3 , and A 4  are N; 
 R 7 , R 8 , and R 9 , are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , —OR y1 , —OC(O)R y2 , —OC(O)NR y3 R y4 , —SR y1 , —S(O) 2 R 1, —S(O) 2 NR y3 R 4 , —C(O)R y1 , —C(O)OR 1, —C(O)NR y3 R y4 , —NR y3 R y4 , —N(R y3 )C(O)R y2 , —N(R y3 )S(O) 2 R y2 , —N(R y3 )C(O)O(R y2 ), —N(R y3 )C(O)NR y3 R y4 , —N(R y3 )S(O) 2 NR 3 R y4 , G 3 , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-OR y1 , —(C 1 -C 6  alkylenyl)-OC(O)R 2 , —(C 1 -C 6  alkylenyl)-OC(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R y1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-C(O)R y1 , —(C 1 -C 6  alkylenyl)-C(O)OR y1 , —(C 1 -C 6  alkylenyl)-C(O)NR y3 R 4 , —(C 1 -C 6  alkylenyl)-NR y3 R 4 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 R y2 , —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)O(R y2 ), —(C 1 -C 6  alkylenyl)-N(R y3 )C(O)NR y3 R y4 , —(C 1 -C 6  alkylenyl)-N(R y3 )S(O) 2 NR y3 R y4 , —(C 1 -C 6  alkylenyl)-CN, or —(C 1 -C 6  alkylenyl)-G 3 ; 
 R y1 , R y3 , and R y4 , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 3 , —(C 1 -C 6  alkylenyl)-G 3 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 R y2 , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 3 , —(C 1 -C 6  alkylenyl)-G 3 , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , or —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d ; 
 G 3 , at each occurrence, is independently aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocycle; and each G 3  group is optionally substituted with 1, 2, 3, 4, or 5 R 4g  groups; 
 R 10  is H, C 1 -C 3  alkyl, halogen, C 1 -C 3  haloalkyl, or —CN; 
 R 1g , R 2g , and R 4 , at each occurrence, is independently selected from the group consisting of oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , G 2a , —OR a , —OC(O)R b , —OC(O)NR c R d , —SR a , —S(O) 2 R a , —S(O) 2 NR c R d , —C(O)R a , —C(O)OR a , —C(O)NR c R d , —NR c R d , —N(R e )C(O)R b , —N(R e )S(O) 2 R b , —N(R e )C(O)O(R b ), —N(R e )C(O)NR c R d , —N(R e )S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-CN, —(C 1 -C 6  alkylenyl)-G 2a , —(C 1 -C 6  alkylenyl)-OR a , —(C 1 -C 6  alkylenyl)-OC(O)R b , —(C 1 -C 6  alkylenyl)-OC(O)NR c R d , —(C 1 -C 6  alkylenyl)-S(O) 2 R a , —(C 1 -C 6  alkylenyl)-S(O) 2 NR c R d , —(C 1 -C 6  alkylenyl)-C(O)R a , —(C 1 -C 6  alkylenyl)-C(O)OR a , —(C 1 -C 6  alkylenyl)-C(O)NR c R d , —(C 1 -C 6  alkylenyl)-NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )C(O)R b , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 R b , —(C 1 -C 6  alkylenyl)-N(R e )C(O)O(R b ), —(C 1 -C 6  alkylenyl)-N(R e )C(O)NR c R d , —(C 1 -C 6  alkylenyl)-N(R e )S(O) 2 NR c R d , or —(C 1 -C 6  alkylenyl)-CN; 
 R a , R c , R d , and R e , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 2a , or —(C 1 -C 6  alkylenyl)-G 2a ; 
 R b , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  haloalkyl, G 2a , or —(C 1 -C 6  alkylenyl)-G 2a ; 
 G 2a , at each occurrence, are each independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl; and each G 2a  group is optionally substituted with 1, 2, 3, 4, or 5 R 3g  groups; 
 R 3g , at each occurrence, is independently oxo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, halogen, C 1 -C 6  haloalkyl, —CN, NO 2 , —OR z1 , —OC(O)R z2 , —OC(O)NR z3 R z4 , —SR z1 , —S(O) 2 R z1 , —S(O) 2 NR z3 R z4 , —C(O)R z1 , —C(O)OR z1 , —C(O)NR z3 R z4 , —NR z3 R z4 , —N(R z3 )C(O)R z2 , —N(R z3 )S(O) 2 R 2 , —N(R z3 )C(O)O(R z2 ), —N(R z3 )C(O)NR z3 R z4 , —N(R z3 )S(O) 2 NR 3 R 4 , —(C 1 -C 6  alkylenyl)-OR z1 , —(C 1 -C 6  alkylenyl)-OC(O)R z2 , —(C 1 -C 6  alkylenyl)-OC(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-S(O) 2 R z1 , —(C 1 -C 6  alkylenyl)-S(O) 2 NR z3 R z4 , —(C 1 -C 6  alkylenyl)-C(O)R z1 , —(C 1 -C 6  alkylenyl)-C(O)OR z1 , —(C 1 -C 6  alkylenyl)-C(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-NR z3 R z4 , —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)R z2 , —(C 1 -C 6  alkylenyl)-N(R z3 )S(O) 2 R z2 , —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)O(R z2 ), —(C 1 -C 6  alkylenyl)-N(R z3 )C(O)NR z3 R z4 , —(C 1 -C 6  alkylenyl)-N(R z3 )S(O) 2 NR 3 R 4 , or —(C 1 -C 6  alkylenyl)-CN; 
 R z1 , R z3 , and R z4 , at each occurrence, are each independently H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, or C 1 -C 6  haloalkyl; and 
 R z2 , at each occurrence, is independently C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, or C 1 -C 6  haloalkyl. 
 
     
     
         36 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
 4-(cyclopropylmethyl)-7-(isopropylsulfonyl)-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropylmethyl)-7-(ethylsulfonyl)-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropylmethyl)-3-ethyl-7-(ethylsulfonyl)-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-(methylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(1H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropylmethyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 4-(cyclopropylmethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxylate; 
 4-(4-fluorophenyl)-10-methyl-7-(methylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropylmethyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulene-7-sulfonamide; 
 4-(4-fluorophenyl)-7,10-dimethyl-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropylmethyl)-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl 3-(4-(cyclopropylmethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoate; 
 4-(cyclopropylmethyl)-3-(2-methoxyethyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-benzyl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl 3-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoate; 
 10-methyl-7-((methylsulfonyl)methyl)-3-phenethyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-isobutyl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (E)-3-(4-fluorostyryl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 7-amino-4-(4-fluorophenyl)-10-methyl-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 N-(4-(4-fluorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-7-yl)ethanesulfonamide; 
 N-(4-(2,4-difluorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-7-yl)ethanesulfonamide; 
 4-butyl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 tert-butyl 3-((10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)methyl)pyrrolidine-1-carboxylate; 
 10-methyl-7-((methylsulfonyl)methyl)-4-((tetrahydrofuran-3-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((4,4-difluorocyclohexyl)methyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 tert-butyl 4-((10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)methyl)piperidine-1-carboxylate; 
 10-methyl-7-((methylsulfonyl)methyl)-4-((tetrahydro-2H-pyran-3-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4,4-difluorocyclohexyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-fluorophenyl)-(3,3- 2 H 2 )-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 7-fluoro-4-(4-fluorophenyl)-10-methyl-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-fluorophenyl)-7,10-dimethyl-3-phenyl-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxylate; 
 tert-butyl 4-(4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carbonyl)piperazine-1-carboxylate; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyrrolidin-3-ylmethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(piperidin-4-ylmethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 7-fluoro-10-methyl-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 7-fluoro-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulene-3-carboxylate; 
 4-(4-fluorophenyl)-3-(4-methoxypiperidine-1-carbonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-fluorophenyl)-10-methyl-3-(4-methylpiperazine-1-carbonyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 5,7-difluoro-10-methyl-4-((tetrahydrofuran-3-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 4-(4-fluorophenyl)-7,10-dimethyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulene-3-carboxylate; 
 N-cyclopentyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-ethyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 4-butyl-5,7-difluoro-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 5,7-difluoro-10-methyl-4-propyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropylmethyl)-5,7-difluoro-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl 4-(5,7-difluoro-10-methyl-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)butanoate; 
 5,7-difluoro-10-methyl-4-(3-phenylpropyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-N-(o-tolyl)-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 2-ethylhexyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-isobutyryl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 5,7-difluoro-10-methyl-4-phenethyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5,7-difluoro-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((1Z,3E)-2,4-diphenylbuta-1,3-dien-1-yl)-5,7-difluoro-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 4-(4-chlorophenyl)-N-ethyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 4-(4-chlorophenyl)-10-methyl-2-(4-methylpiperazine-1-carbonyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-(2,6-dimethylphenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(4-methoxyphenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(4-ethylphenethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-N-propyl-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(3-methoxybenzyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(2-chloroethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(cyclohexylmethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(4-isopropylphenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(2,6-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 N-(4-fluoro-3-(trifluoromethyl)phenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 ethyl 4-((10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4-carboxamido)methyl)cyclohexanecarboxylate; 
 N-(3-methoxypropyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 10-methyl-7-((methylsulfonyl)methyl)-4-tosyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-([1,1′-biphenyl]-4-ylsulfonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((4-methoxyphenyl)sulfonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(phenylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((2-methoxyphenyl)sulfonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-((4-phenoxyphenyl)sulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((4-fluorophenyl)sulfonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2-naphthoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoate; 
 4-(2,4-difluorophenyl)-10-methyl-3,4-dihydro-1H-1,4,5,7,10-pentaazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)-ethyl 4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxylate; 
 (S)-ethyl 4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxylate; 
 2-methoxyethyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 ethyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 pentyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-chlorobutyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 naphthalen-2-yl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 p-tolyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 neopentyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 phenyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-fluorophenyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 2-methoxyphenyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 2-fluoroethyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-methoxyphenyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 but-2-yn-1-yl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanamide; 
 4-(4-fluorobenzoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(3-methoxypropanoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-([1,1′-biphenyl]-4-carbonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(3-cyclopentylpropanoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2-(3-methoxyphenyl)acetyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-propionyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-4-(3-methylbutanoyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(3,3-dimethylbutanoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(2-phenylacetyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-benzoyl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-methoxybenzoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl 4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)-4-oxobutanoate; 
 4-(2,4-difluorobenzoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2-fluorobenzoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(1-naphthoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropanecarbonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(3-phenylpropanoyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 2-((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)isoindoline-1,3-dione; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)-N-methylpropanamide; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)-N,N-dimethylpropanamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(3-morpholino-3-oxopropyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)-N-(tetrahydro-2H-pyran-4-yl)propanamide; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)-N′-methyl-N′-phenylpropanehydrazide; 
 N-benzyl-3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanamide; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)propanamide; 
 tert-butyl 4-(3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoyl)piperazine-1-carboxylate; 
 tert-butyl 4-(3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanamido)piperidine-1-carboxylate; 
 4-(4-chlorophenyl)-N-ethyl-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 6-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)hexyl acetate; 
 3-(aminomethyl)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-((((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)amino)(dimethylamino)methylene)-N-methylmethanaminium; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(3-oxo-3-(piperazin-1-yl)propyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)-N-(piperidin-4-yl)propanamide; 
 4-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)butane-1,2-diyl diacetate; 
 methyl 5-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)pentanoate; 
 tert-butyl (2-(((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)amino)-2-oxoethyl)carbamate; 
 4-(2,4-difluorophenyl)-3-(6-hydroxyhexyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)benzamide; 
 1-((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)-3-phenylurea; 
 2-amino-N-((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)acetamide; 
 4-(2,4-difluorophenyl)-3-(3,4-dihydroxybutyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-3-(3-hydroxypropyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(3-phenoxypropyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (S)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(3-phenoxypropyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(3-phenoxypropyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-2-((4-methylpiperazin-1-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-3-(3-methoxypropyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-3-(3-ethoxypropyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-isobutyl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((1-ethylpiperidin-3-yl)methyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(tetrahydro-2H-pyran-4-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-ethoxybutan-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-(2-cyanoethyl)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 methyl 2-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamido)acetate; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-N-phenethyl-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 N-butyl-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 N-cyclohexyl-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 N-benzyl-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-N-(3-phenylpropyl)-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-N-isobutyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-N-(2-hydroxyethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-N-(oxazol-4-ylmethyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 N-(cyclopropylmethyl)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-N-(2-hydroxy-2-methylpropyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-N-(1-(hydroxymethyl)cyclopropyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-10-methyl-N-(1-methylcyclopropyl)-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-N-(4-phenylbutyl)-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxamide; 
 4-(3,3-dimethylbutanoyl)-5,7-difluoro-10-methyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 tert-butyl ((trans)-4-(10-methyl-7-(methylsulfonyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 4-((trans)-4-aminocyclohexyl)-10-methyl-7-(methylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(cyclopropyl sulfonyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 5,7-difluoro-10-methyl-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-(2,4-difluorophenyl)-10-methyl-3-(3-(methylamino)propyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-3-(3-(dimethylamino)propyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-2-((4-methylpiperazin-1-yl)methyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 2-(4-(4-fluorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-7-yl)acetonitrile; 
 4-(2,2-dimethyl-3-(pyrrolidin-1-yl)propyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 2-(3-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)pyrrolidin-1-yl)acetic acid; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(2-methyltetrahydrofuran-3-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-4-(1-methylpiperidin-4-yl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(tetrahydro-2H-pyran-3-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-((1-isopropylpiperidin-4-yl)methyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(1-(2-oxotetrahydrofuran-3-yl)ethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(1-methoxypropan-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-methoxybutan-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-4-(1-methylpyrrolidin-3-yl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-4-(1-methylazepan-4-yl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(1-ethylpiperidin-3-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)benzonitrile; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-2-(morpholinomethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-ethyl-4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 5-cyclopropyl-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 tert-butyl (4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 tert-butyl ((trans)-4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carbonitrile; 
 4-(2,4-difluorophenyl)-3-(hydroxymethyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carbonitrile; 
 4-(2,4-difluorophenyl)-N-ethyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 4-(4-cyanophenyl)-N-ethyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 (S)-2-((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)isoindoline-1,3-dione; 
 (R)-2-((4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)methyl)isoindoline-1,3-dione; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-5-carbonitrile; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxylate; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carbonitrile; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-aminocyclohexyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(3,5-difluoropyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-phenyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-phenyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (S)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-phenyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(naphthalen-1-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-(3,3- 2 H 2 )-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-neopentyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-((1-oxoisoindolin-2-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-3-(2,6-dimethoxyphenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-3-(3,5-dimethoxyphenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-(3,5-di-tert-butylphenyl)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl (4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 methyl ((trans)-4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 methyl ((cis)-4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 2-(2-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)ethyl)isoindoline-1,3-dione; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(tetrahydro-2H-pyran-4-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 benzyl (2-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)ethyl)carbamate; 
 3-([1,1′-biphenyl]-2-yl)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(quinolin-8-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-(4-(1H-imidazol-1-yl)phenyl)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)benzonitrile; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-(3-(pyridin-2-yl)phenyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)benzonitrile; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-((2-oxopyridin-1(2H)-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 4-(2,4-difluorophenyl)-2-(ethylcarbamoyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-3-carboxylate; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-5-carboxamide; 
 4-(2,4-difluorophenyl)-N, 10-dimethyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-5-carboxamide; 
 4-(2,4-difluorophenyl)-N,N, 10-trimethyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-5-carboxamide; 
 N-(4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)acetamide; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyridin-3-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(5-chloropyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(1H-indazol-5-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-benzyl-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyrimidin-5-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyridin-2-ylmethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyridazin-3-ylmethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (S)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-((2-oxopyridin-1(2H)-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3-((2-oxopyridin-1(2H)-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(5-(trifluoromethyl)pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2-fluoropyridin-4-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-4-((1-methyl-1H-pyrazol-3-yl)methyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(6-methoxypyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,2-dimethyl-3-morpholinopropyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(5-fluoropyrimidin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyrimidin-4-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2-(3-(dimethylamino)propoxy)benzyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 2-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)-2-phenylacetonitrile; 
 2-(2-((10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)methyl)phenoxy)acetamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxylic acid; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(2-(pyridin-2-ylmethoxy)benzyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)-7-(ethylsulfonyl)-10-methyl-4-(1-phenylethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-4-(pyridin-2-yl)-7-(pyrrolidin-1-ylsulfonyl)-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 (S)-7-(ethylsulfonyl)-10-methyl-4-(1-phenylethyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)-methyl 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoate; 
 (S)-methyl 3-(4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoate; 
 4-(2,4-difluorophenyl)-10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 (R)—N-ethyl-7-(ethyl sulfonyl)-10-methyl-11-oxo-4-(1-phenylpropyl)-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-((methylsulfonyl)methyl)-4-(pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-4-phenyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-4-(pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; and 4-(4-fluorophenyl)-10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one. 
 
     
     
         37 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
 4-(cyclopropylmethyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 methyl 3-(4-(cyclopropylmethyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulen-3-yl)propanoate; 
 4-(cyclopropylmethyl)-3-(2-methoxyethyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-(4-(4-fluorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-7-yl)ethanesulfonamide; 
 N-(4-(2,4-difluorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-7-yl)ethanesulfonamide; 
 10-methyl-7-((methylsulfonyl)methyl)-4-((tetrahydrofuran-3-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4,4-difluorocyclohexyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-fluorophenyl)-(3,3- 2 H 2 )-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 7-fluoro-4-(4-fluorophenyl)-10-methyl-3,4-dihydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-11(10H)-one; 
 5,7-difluoro-10-methyl-4-((tetrahydrofuran-3-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 5,7-difluoro-10-methyl-4-propyl-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 4-(4-chlorophenyl)-N-ethyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-N-propyl-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxamide; 
 ethyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 p-tolyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-fluorophenyl 10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; and 
 4-(3,3-dimethylbutanoyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one. 
 
     
     
         38 . The compound of  claim 1  or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
 4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-(4-(4-fluorophenyl)-10-methyl-11-oxo-3,4,10,11-tetrahydro-1H-1,4,5,10-tetraazadibenzo[cd,f]azulen-7-yl)ethanesulfonamide; 
 10-methyl-7-((methylsulfonyl)methyl)-4-((tetrahydrofuran-3-yl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 ethyl 5,7-difluoro-10-methyl-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulene-4(3H)-carboxylate; 
 4-(4-chlorophenyl)-10-methyl-2-((4-methylpiperazin-1-yl)methyl)-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 N-ethyl-4-(4-fluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 5-cyclopropyl-4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 tert-butyl (4-(10-methyl-7-((methylsulfonyl)methyl)-11-oxo-10,11-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-4(3H)-yl)cyclohexyl)carbamate; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(4-chlorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carbonitrile; 
 4-(2,4-difluorophenyl)-N-ethyl-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-2-carboxamide; 
 4-(2,4-difluorophenyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-5-carbonitrile; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(3,5-difluoropyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 10-methyl-7-((methylsulfonyl)methyl)-4-(5-(trifluoromethyl)pyridin-2-yl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; 
 4-(6-methoxypyridin-2-yl)-10-methyl-7-((methylsulfonyl)methyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one; and 
 4-(4-chlorophenyl)-10-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-(methylsulfonyl)-3,4-dihydro-1H-1,4,10-triazadibenzo[cd,f]azulen-11(10H)-one. 
 
     
     
         39 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) according to  claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 
     
     
         40 . A method for treating cancer in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof. 
     
     
         41 . The method of  claim 40  wherein the cancer is selected from the group consisting of: acoustic neuroma, acute leukemia, acute lymphocytic leukemia, acute myelocytic leukemia (monocytic, myeloblastic, adenocarcinoma, angiosarcoma, astrocytoma, myelomonocytic and promyelocytic), acute t-cell leukemia, basal cell carcinoma, bile duct carcinoma, bladder cancer, brain cancer, breast cancer, bronchogenic carcinoma, cervical cancer, chondrosarcoma, chordoma, choriocarcinoma, chronic leukemia, chronic lymphocytic leukemia, chronic myelocytic (granulocytic) leukemia, chronic myelogenous leukemia, colon cancer, colorectal cancer, craniopharyngioma, cystadenocarcinoma, diffuse large B-cell lymphoma, dysproliferative changes (dysplasias and metaplasias), embryonal carcinoma, endometrial cancer, endotheliosarcoma, ependymoma, epithelial carcinoma, erythroleukemia, esophageal cancer, estrogen-receptor positive breast cancer, essential thrombocythemia, Ewing&#39;s tumor, fibrosarcoma, follicular lymphoma, germ cell testicular cancer, glioma, glioblastoma, gliosarcoma, heavy chain disease, hemangioblastoma, hepatoma, hepatocellular cancer, hormone insensitive prostate cancer, leiomyosarcoma, leukemia, liposarcoma, lung cancer, lymphagioendotheliosarcoma, lymphangiosarcoma, lymphoblastic leukemia, lymphoma (Hodgkin&#39;s and non-Hodgkin&#39;s), malignancies and hyperproliferative disorders of the bladder, breast, colon, lung, ovaries, pancreas, prostate, skin, and uterus, lymphoid malignancies of T-cell or B-cell origin, leukemia, lymphoma, medullary carcinoma, medulloblastoma, melanoma, meningioma, mesothelioma, multiple myeloma, myelogenous leukemia, myeloma, myxosarcoma, neuroblastoma, NUT midline carcinoma (NMC), non-small cell lung cancer, oligodendroglioma, oral cancer, osteogenic sarcoma, ovarian cancer, pancreatic cancer, papillary adenocarcinomas, papillary carcinoma, pinealoma, polycythemia vera, prostate cancer, rectal cancer, renal cell carcinoma, retinoblastoma, rhabdomyosarcoma, sarcoma, sebaceous gland carcinoma, seminoma, skin cancer, small cell lung carcinoma, solid tumors (carcinomas and sarcomas), small cell lung cancer, stomach cancer, squamous cell carcinoma, synovioma, sweat gland carcinoma, thyroid cancer, Waldenstrom&#39;s macroglobulinemia, testicular tumors, uterine cancer and Wilms&#39; tumor. 
     
     
         42 . A method for treating a disease or condition in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said disease or condition is selected from the group consisting of Addison&#39;s disease, acute gout, ankylosing spondylitis, asthma, atherosclerosis, Behcet&#39;s disease, bullous skin diseases, cardiac myopathy, cardiac hypertrophy, chronic obstructive pulmonary disease (COPD), Crohn&#39;s disease, dermatitis, eczema, giant cell arteritis, glomerulonephritis, heart failure, hepatitis, hypophysitis, inflammatory bowel disease, Kawasaki disease, lupus nephritis, multiple sclerosis, myocarditis, myositis, nephritis, organ transplant rejection, osteoarthritis, pancreatitis, pericarditis, Polyarteritis  nodosa , pneumonitis, primary biliary cirrhosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, scleritis, sclerosing cholangitis, sepsis systemic lupus erythematosus, Takayasu&#39;s Arteritis, toxic shock, thyroiditis, type I diabetes, ulcerative colitis, uveitis, vitiligo, vasculitis, and Wegener&#39;s granulomatosis. 
     
     
         43 . A method for treating a chronic kidney disease or condition in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said disease or condition is selected from the group consisting of: diabetic nephropathy, hypertensive nephropathy, HIV-associated nephropathy, glomerulonephritis, lupus nephritis, IgA nephropathy, focal segmental glomerulosclerosis, membranous glomerulonephritis, minimal change disease, polycystic kidney disease, and tubular interstitial nephritis. 
     
     
         44 . A method for treating an acute kidney disease or condition in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said acute kidney disease or condition is selected from the group consisting of: ischemia-reperfusion induced kidney disease, cardiac and major surgery induced kidney disease, percutaneous coronary intervention induced kidney disease, radio-contrast agent induced kidney disease, sepsis induced kidney disease, pneumonia induced kidney disease, and drug toxicity induced kidney disease. 
     
     
         45 . A method for treating an acquired immunodeficiency syndrome (AIDS) in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof. 
     
     
         46 . A method for treating a disease or condition in a subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein said disease or condition is selected from the group consisting of: obesity, dyslipidemia, hypercholesterolemia, Alzheimer&#39;s disease, metabolic syndrome, hepatic steatosis, type II diabetes, insulin resistance, diabetic retinopathy, and diabetic neuropathy. 
     
     
         47 . A method of contraception in a male subject comprising administering a therapeutically effective amount of a compound of formula (I) according to  claim 1  or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
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