Anti-hemorrhaging compositions

Abstract

Compositions comprising a citrate salt and a calcium carbonate-containing material, articles-of-manufacturing and kits comprising same and uses thereof for inducing blood coagulation and/or for reducing or arresting hemorrhaging, particularly internal hemorrhaging, are disclosed.

What is claimed is: 
     
         1 . A blood coagulation-inducing composition comprising a citrate salt and a calcium-carbonate containing material. 
     
     
         2 . The composition of  claim 1 , wherein the calcium carbonate-containing material comprises crystalline calcium carbonate. 
     
     
         3 . The composition of  claim 1 , wherein said calcium carbonate-containing material comprises a coral exoskeleton. 
     
     
         4 . The composition of  claim 1 , wherein said calcium carbonate-containing material comprises acellular coral exoskeleton. 
     
     
         5 . The composition of  claim 1 , wherein said calcium carbonate-containing material comprises aragonite. 
     
     
         6 . The composition of  claim 1 , wherein said calcium carbonate-containing material comprises biogenic aragonite. 
     
     
         7 . The composition of  claim 1 , wherein said calcium carbonate-containing material comprises geological aragonite. 
     
     
         8 . The composition of  claim 1 , wherein the calcium carbonate-containing material comprises amorphous calcium carbonate. 
     
     
         9 . The composition of  claim 1 , wherein said calcium carbonate-containing material is a particulate material. 
     
     
         10 . The composition of  claim 9 , said particulate material comprises particles having an average particle diameter in the range of from 0.1 micron to 10 millimeter, or from 0.1 micron to 1 millimeter, or from 0.1 micron to 500 microns, or from 0.5 microns to 500 microns, or from 1 micron to 500 microns, or from 5.0 microns to 500 microns. 
     
     
         11 . The composition of  claim 1 , wherein a weight ratio of said citrate and said calcium carbonate-containing material ranges from 10:1 to 1:300. 
     
     
         12 . The composition of  claim 1 , being formulated as a topical dosage form. 
     
     
         13 . The composition of  claim 12 , being in a form of a powder, a gel, a spray, a foam, a mousse, an ointment, a paste, a lotion, a gauze, a wound dressing, a suspension, an adhesive bandage, a non-adhesive bandage, a wipe, a gauze, a pad, and a sponge. 
     
     
         14 . An article-of-manufacturing comprising the composition of  claim 1 , the article-of-manufacturing being configured for applying the composition to an injured blood vessel and/or tissue. 
     
     
         15 . A kit comprising the composition of  claim 1 . 
     
     
         16 . The kit of  claim 15 , wherein the calcium carbonate-containing material and the citrate salt are packaged together within the kit. 
     
     
         17 . The kit of  claim 15 , wherein the calcium carbonate-containing material and the citrate salt are packaged individually within the kit. 
     
     
         18 . The kit of  claim 15 , comprising an article-of-manufacturing comprising the composition and configured for applying the composition to an injured blood vessel and/or tissue. 
     
     
         19 . A method of inducing coagulation of blood, the method comprising contacting the blood with the composition of  claim 1 . 
     
     
         20 . The method of  claim 19 , wherein said contacting comprises contacting the blood with an article-of-manufacturing comprising the composition and configured for applying the composition to an injured blood vessel and/or tissue. 
     
     
         21 . The method of  claim 19 , wherein at least 50% of the blood is clotted upon contacting with the composition for less than 10 minutes. 
     
     
         22 . The method of  claim 19 , wherein at least 50% of said clotted blood remains clotted for at least 2 hours. 
     
     
         23 . The method of  claim 19 , wherein said contacting is effected in vivo. 
     
     
         24 . The method of  claim 23 , wherein said contacting comprises applying the composition to an injured blood vessel. 
     
     
         25 . The method of  claim 24 , wherein said blood vessel is an internal blood vessel or a blood vessel of an internal tissue. 
     
     
         26 . A method of reducing or arresting hemorrhaging in a subject in need thereof, the method comprising contacting an injured blood vessel or tissue of the subject with the composition of  claim 1 . 
     
     
         27 . The method of  claim 26 , wherein the hemorrhaging is an internal hemorrhaging.