Nutritional supplement for increasing cognitive functions

Abstract

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods are useful to increase oxygenation of the brain and to improve cognitive function.

1 - 19 . (canceled) 
     
     
         20 . A method to increase NO levels in the blood of a mammal comprising administering two unit dosage forms a day to the mammal, wherein each unit dosage form comprises:
 L-citrulline 500 mg±20 mg;   L-arginine 250 mg±20 mg; and   at least about 5 mg piperine.   
     
     
         21 . The method of  claim 20  wherein each unit dosage form comprises at least about 5.5 mg piperine. 
     
     
         22 . The method of  claim 20  wherein each unit dosage form comprises at least about 480 mg of L-citrulline. 
     
     
         23 . The method of  claim 20  wherein each unit dosage form comprises at least about 230 mg of L-arginine. 
     
     
         24 . The method of  claim 20  wherein each unit dosage form further comprises microcrystalline cellulose, silicon dioxide, and magnesium sterate. 
     
     
         25 . The method of  claim 20  wherein each unit dosage form is formulated as a capsule, powder, or liquid. 
     
     
         26 . A method to increase oxygenation of the brain in a mammal comprising administering two unit dosage forms a day to the mammal, wherein each unit dosage form comprises:
 L-citrulline 500 mg±20 mg;   L-arginine 250 mg±20 mg; and   at least about 5 mg piperine.   
     
     
         27 . The method of  claim 26  wherein each unit dosage form comprises at least about 5.5 mg piperine. 
     
     
         28 . The method of  claim 26  wherein each unit dosage form comprises at least about 480 mg of L-citrulline. 
     
     
         29 . The method of  claim 26  wherein each unit dosage form comprises at least about 230 mg of L-arginine. 
     
     
         30 . The method of  claim 26  wherein each unit dosage form further comprises microcrystalline cellulose, silicon dioxide, and magnesium sterate. 
     
     
         31 . The method of  claim 26  wherein each unit dosage form is formulated as a capsule, powder, or liquid. 
     
     
         32 . A method to improve cognitive function in a mammal comprising administering two unit dosage forms a day to the mammal, wherein each unit dosage form comprises:
 L-citrulline 500 mg±20 mg;   L-arginine 250 mg±20 mg; and   at least about 5 mg piperine.   
     
     
         33 . The method of  claim 32  wherein each unit dosage form comprises at least about 5.5 mg piperine. 
     
     
         34 . The method of  claim 32  wherein each unit dosage form comprises at least about 480 mg of L-citrulline. 
     
     
         35 . The method of  claim 32  wherein each unit dosage form comprises at least about 230 mg of L-arginine. 
     
     
         36 . The method of  claim 32  wherein each unit dosage form further comprises microcrystalline cellulose, silicon dioxide, and magnesium sterate. 
     
     
         37 . The method of  claim 32  wherein each unit dosage form is formulated as a capsule, powder, or liquid.