Oral rehydration composition with oligosaccharides

Abstract

The general inventive concepts are directed to compositions and methods for the prevention and treatment of dehydration. Provided herein are nutritional compositions including oral rehydration compositions. Certain embodiments of the nutritional compositions have an acidic pH, and comprise a digestible carbohydrate, sodium, citrate, and an oligosaccharide selected from a fucosylated oligosaccharide and an N-acetylated oligosaccharide.

1 - 42 . (canceled) 
     
     
         43 . A nutritional composition comprising:
 a human milk oligosaccharide selected from the group consisting of a fucosylated oligosaccharide, an N-acetylated oligosaccharide, and combinations thereof in an amount of 10 mg to 5000 mg per liter of the nutritional composition;   a digestible carbohydrate in addition to the human milk oligosaccharide in an amount of from 10 mM to 150 mM of carbohydrate of the nutritional composition; and   sodium in an amount of 10 mEq to 100 mEq of sodium per liter of the nutritional composition;   and wherein the nutritional composition is shelf stable for at least three months.   
     
     
         44 . The nutritional composition of  claim 43 , wherein the human milk oligosaccharide is selected from 2′-fucosyllactose and lacto-N-neotetraose. 
     
     
         45 . The nutritional composition of  claim 44 , wherein the human milk oligosaccharide is 2′-fucosyllactose. 
     
     
         46 . The nutritional composition of  claim 45 , wherein the 2′-fucosyllactose is present in an amount of 20 mg to 4000 mg per liter of the nutritional composition. 
     
     
         47 . The nutritional composition of  claim 45  further comprising at least one neutral human milk oligosaccharide. 
     
     
         48 . The nutritional composition of  claim 43  wherein the nutritional composition does not comprise a sialylated oligosaccharide. 
     
     
         49 . The nutritional composition of  claim 43 , wherein the nutritional composition is shelf stable for at least six months. 
     
     
         50 . The nutritional composition of  claim 45  further comprising galactooligosaccharides. 
     
     
         51 . The nutritional composition of  claim 45  further comprising at least one of protein and fat. 
     
     
         52 . The nutritional composition of  claim 45 , wherein the digestible carbohydrate is selected from the group consisting of dextrose, maltodextrin, starch, isomaltulose, sucromalt, rice syrup, and rice syrup solids. 
     
     
         53 . The nutritional composition of  claim 45 , wherein the digestible carbohydrate is dextrose. 
     
     
         54 . The nutritional composition of  claim 45 , wherein the sodium is selected from the group consisting of sodium chloride, sodium phosphate, sodium citrate, sodium carbonate, sodium bicarbonate, sodium hydroxide, sodium ascorbate and combinations thereof. 
     
     
         55 . The nutritional composition of  claim 45  further comprising a probiotic. 
     
     
         56 . The nutritional composition of  claim 45  further comprising chloride. 
     
     
         57 . The nutritional composition of  claim 56 , wherein the chloride is selected from the group consisting of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and combinations thereof. 
     
     
         58 . The nutritional composition of  claim 45  further comprising zinc. 
     
     
         59 . The nutritional composition of  claim 58 , wherein the zinc is selected from the group consisting of zinc gluconate, zinc sulfate, zinc chloride, zinc citrate, zinc bicarbonate, zinc carbonate, zinc hydroxide, zinc lactate, zinc acetate, zinc fluoride, zinc bromide, zinc sulfonate, and combinations thereof. 
     
     
         60 . The nutritional composition of  claim 45  further comprising citrate. 
     
     
         61 . The nutritional composition of  claim 60 , wherein the citrate is selected from the group consisting of potassium citrate, sodium citrate, zinc citrate, and combinations thereof. 
     
     
         62 . An aqueous oral rehydration composition comprising:
 a human milk oligosaccharide selected from the group consisting of a fucosylated oligosaccharide, an N-acetylated oligosaccharide, and combinations thereof in an amount of 10 mg to 5000 mg per liter of the nutritional composition;   a digestible carbohydrate in addition to the human milk oligosaccharide in an amount of from 10 mM to 150 mM of carbohydrate of the nutritional composition; and   sodium in an amount of 10 mEq to 100 mEq of sodium per liter of the nutritional composition;   wherein the aqueous oral rehydration composition has a pH of about 2 to about 6.5 and is shelf stable for at least three months after heat sterilization.