Stable hydrogel compositions including additives

Abstract

The present specification generally relates to an injectable dermal filler composition that includes crosslinked hyaluronic acid-based polymer and an antioxidant.

1 - 13 . (canceled) 
     
     
         14 . A dermal filler composition comprising a crosslinked hyaluronic acid-based polymer and at least one phenolic antioxidant. 
     
     
         15 . The composition of  claim 14 , wherein the antioxidant is a water-soluble glycosylated derivative of a non-water-soluble antioxidant. 
     
     
         16 . The composition of  claim 14 , wherein the phenolic antioxidant is a flavonoid. 
     
     
         17 . The composition of  claim 14 , where the composition is substantially stable during sterilization with a heat treatment above 100° C. 
     
     
         18 . The composition of  claim 14 , wherein the antioxidant is a glucosylated caffeic acid, a glucosylated epicatechin gallate or a glucosylated epigallocatechin gallate. 
     
     
         19 . The composition of  claim 14 , wherein free radical stability of the composition is significantly increased by the addition of the antioxidant, with a T 30  increase of at least about 25%. 
     
     
         20 . The composition of  claim 14 , wherein free radical stability of the composition is significantly increased by the addition of the antioxidant, with a T 30  increase of at least about 50%. 
     
     
         21 . The composition of  claim 14 , wherein free radical stability of the composition is significantly increased by the addition of the antioxidant, with a T 30  increase of at least about 100%. 
     
     
         22 . The composition of  claim 14 , wherein the hyaluronic acid-based polymer is crosslinked with 1,4-butanediol diglycidyl ether. 
     
     
         23 . The composition of  claim 14  further comprising lidocaine. 
     
     
         24 . The composition of  claim 23 , wherein the lidocaine is present in an amount of about 0.3% w/w. 
     
     
         25 . A method of reducing the appearance of a soft tissue condition in skin of a patient, the method comprising administering by injection into the skin of the patient a dermal filler composition comprising a crosslinked hyaluronic acid-based polymer and at least one phenolic antioxidant. 
     
     
         26 . The method of  claim 25 , wherein the antioxidant is a water-soluble glycosylated derivative of a non-water-soluble antioxidant. 
     
     
         27 . The method of  claim 25 , wherein the phenolic antioxidant is a flavonoid. 
     
     
         28 . The method of  claim 25 , wherein the antioxidant is a glucosylated caffeic acid, a glucosylated epicatechin gallate or a glucosylated epigallocatechin gallate. 
     
     
         29 . A method of reducing the appearance of wrinkles in skin of a patient, the method comprising administering by injection into the skin of the patient a dermal filler composition comprising a crosslinked hyaluronic acid-based polymer and at least one phenolic antioxidant. 
     
     
         30 . The method of  claim 29 , wherein the antioxidant is a water-soluble glycosylated derivative of a non-water-soluble antioxidant. 
     
     
         31 . The method of  claim 29 , wherein the phenolic antioxidant is a flavonoid. 
     
     
         32 . The method of  claim 29 , wherein the antioxidant is a glucosylated caffeic acid, a glucosylated epicatechin gallate or a glucosylated epigallocatechin gallate.