Composition containing monoacetyldiacylglycerol compound as active ingredient for inhibiting blood cancer or metastasis

Abstract

The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The monoacetyldiglyceride compound according to the present invention has excellent effects of inhibiting the expression of IL-4 and inhibiting the activity of STAT-6, and thereby is capable of overcoming side effects of currently used blood cancer or metastasis inhibiting agents. Also, the monoacetyldiglyceride compound is a non-toxic compound having superior therapeutic effects and thus can be useful as a composition for preventing, treating, or improving blood cancer and metastasis.

1 - 17 . (canceled) 
     
     
         18 . A method for treating a subject suffering from cancer, comprising:
 administering to the subject an effective amount of a compound of Formula I:   
       
         
           
           
               
               
           
         
         wherein R1 and R2 are independently a fatty acid group comprising 14 to 20 carbon atoms, thereby reducing a cytokine in the subject. 
       
     
     
         19 . The method of  claim 18  wherein R1 and R2 are each independently selected from the group consisting of palmitoyl, oleoyl, linoleoyl, linolenoyl, stearoyl, myristoyl, and arachidonoyl. 
     
     
         20 . The method of  claim 18  wherein R1 is palmitoyl. 
     
     
         21 . The method of  claim 20  wherein R2 is linoleoyl. 
     
     
         22 . The method of  claim 18  wherein the subject is identified as suffering from cancer, and compound of Formula I is administered to the identified subject. 
     
     
         23 . The method of  claim 18  wherein the subject is suffering from cancer metastasis. 
     
     
         24 . The method of  claim 18  wherein a pharmaceutical composition formulated for oral administration that comprises the compound of Formula I is administered to the subject. 
     
     
         25 . The method of  claim 18  wherein the subject is a human. 
     
     
         26 . The method of  claim 18  wherein an effective amount of a compound of the following Formula 2 is administered to the subject: 
       
         
           
           
               
               
           
         
       
     
     
         27 . The method of  claim 26  wherein the subject is identified as suffering from cancer, and compound of Formula I is administered to the identified subject. 
     
     
         28 . A method for inhibiting cancer metastasis in a subject in need thereof, comprising:
 administering to the subject an effective amount of a monoacetyldiacylglycerol of Formula I:   
       
         
           
           
               
               
           
         
         wherein R1 and R2 are independently a fatty acid group comprising 14 to 20 carbon atoms, thereby reducing a cytokine in the subject. 
       
     
     
         29 . The method of  claim 28  wherein R1 and R2 are each independently selected from the group consisting of palmitoyl, oleoyl, linoleoyl, linolenoyl, stearoyl, myristoyl, and arachidonoyl. 
     
     
         30 . The method of  claim 28  wherein R1 is palmitoyl. 
     
     
         31 . The method of  claim 30  wherein R2 is linoleoyl. 
     
     
         32 . The method of  claim 28  wherein the subject is identified as suffering from cancer, and compound of Formula I is administered to the identified subject. 
     
     
         33 . The method of  claim 28  wherein a pharmaceutical composition formulated for oral administration that comprises the compound of Formula I is administered to the subject. 
     
     
         34 . The method of  claim 28  wherein an effective amount of a compound of the following Formula 2 is administered to the subject: 
       
         
           
           
               
               
           
         
       
     
     
         35 . The method of  claim 34  wherein the subject is a human. 
     
     
         36 . A method of modulating a cytokine in a subject comprising:
 administering to the subject an effective amount of a compound of Formula 1:   
       
         
           
           
               
               
           
         
         wherein R1 and R2 are independently a fatty acid group comprising 14 to 20 carbon atoms, thereby modulating a cytokine in the subject. 
       
     
     
         37 . The method of  claim 36  wherein the administered compound of Formula 1 is a compound of the following Formula 2: