1,3-diaza-spiro-[3.4]-octane derivatives

Abstract

The invention relates to 1,3-diaza-spiro-[3.4]-octane derivatives, their preparation and use in medicine, particularly in various neurological disorders, including but not limited to pain, neurodegenerative disorders, neuroinflammatory disorders, neuropsychiatric disorders, substance abuse/dependence.

1 . A compound according to general formula (I) 
       
         
           
           
               
               
           
         
         wherein 
         R 1  and R 2  independently of one another mean
 —H; 
 —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —OH, —OCH 3 , —CN and —CO 2 CH 3 ; 
 a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, 
 —Cl, —Br, —I, —OH, —OCH 3 , —CN and —CO 2 CH 3 ; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted; or 
 a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —OH, —OCH 3 , —CN and —CO 2 CH 3 ; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted; 
 or 
 
         R 1  and R 2  together with the nitrogen atom to which they are attached form a ring and mean —(CH 2 ) 3-6 —; 
         —(CH 2 ) 2 —O—(CH 2 ) 2 —; or —(CH 2 ) 2 —NR A —(CH 2 ) 2 —, wherein R A  means —H or —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br and —I; 
         R 3  means
 —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; 
 a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; 
 a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; 
 a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or 
 a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; 
 
         R 4  means
 —H; 
 —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said —C 1 -C 6 -alkyl is optionally connected through —C(═O)—, —C(═O)O—, or —S(═O) 2 —; 
 a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; 
 a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; 
 a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 6-14-membered aryl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; or 
 a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 5-14-membered heteroaryl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; 
 
         R 5  means
 —H; 
 —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said —C 1 -C 6 -alkyl is optionally connected through —C(═O)—, —C(═O)O—, or —S(═O) 2 —; 
 a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; 
 a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; 
 a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 6-14-membered aryl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O)—; or 
 a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 5-14-membered heteroaryl moiety is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —; 
 
         R 6 , R 7 , R 8 , R 9 , R 10 , and R 11  independently of one another mean —H, —F, —Cl, —Br, —I, —OH, or —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; 
         or 
         R 6  and R 7  together mean ═O; 
         wherein “mono- or polysubstituted” means that one or more hydrogen atoms are replaced by substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —R 12 , —C(═O)R 12 , —C(═O)OR 12 , —C(═O)NR 12 R 13 , —O—(CH 2 CH 2 —O) 1-30 —H, —O—(CH 2 CH 2 —O) 1-30 —CH 3 , ═O, —OR 12 , —OC(═O)R 12 , 
         —OC(═O)OR 12 , —OC(═O)NR 12 R 13 , —NO 2 , —NR 12 R 13 , —NR 12 —(CH 2 ) 1-6 —C(═O)R 13 , —NR 12 —(CH 2 ) 1-6 —C(═O)OR 13 , —NR 14 —(CH 2 ) 1-6 —C(═O)NR 12 R 13 , —NR 12 C(═O)R 13 , —NR 12 C(═O)—OR 11 , —NR 14 C(═O)NR 12 R 13 , 
         —NR 12 S(═O) 2 R 13 , —SR 12 , —S(═O)R 12 , —S(═O) 2 R 12 , —S(═O) 2 OR 2 , and —S(═O) 2 NR 12 R 13 ; 
         wherein 
         R 12 , R 13  and R 14  independently of one another mean
 —H; 
 —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, 
 —Br, —I, —CN, ═O, —OH, —NH 2 , —NH—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 , —C 1 -C 6 -alkyl, —O—C 1 -C 6 -alkyl, 
 —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NH—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl and —S(═O) 2 —C 1 -C 6 -alkyl; 
 a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, ═O, —OH, —NH 2 , —NH—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 , —C 1 -C 6 -alkyl, —O—C 1 -C 6 -alkyl, —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NH—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —S-C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl and —S(═O) 2 —C 1 -C 6 -alkyl; 
 a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, ═O, —OH, —NH 2 , —NH—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 , —C 1 -C 6 -alkyl, —O—C 1 -C 6 -alkyl, —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NH—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl and —S(═O) 2 —C 1 -C 6 -alkyl; 
 a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, ═O, —OH, —NH 2 , —NH—C 1 -C 6 -alkyl, 
 —N(C 1 -C 6 -alkyl) 2 , —C 1 -C 6 -alkyl, —O—C 1 -C 6 -alkyl, —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, 
 —C(═O)NH 2 , —C(═O)NH—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl and —S(═O) 2 —C 1 -C 6 -alkyl; or 
 a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, ═O, —OH, 
 —NH 2 , —NH—C 1 -C 6 -alkyl, —N(C 1 -C 6 -alkyl) 2 , —C 1 -C 6 -alkyl, —O—C 1 -C 6 -alkyl, —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NH—C 1 -C 6 -alkyl, —C(═O)N(C 1 -C 6 -alkyl) 2 , —S—C 1 -C 6 -alkyl, —S(═O)—C 1 -C 6 -alkyl and —S(═O) 2 —C 1 -C 6 -alkyl; 
 
         or R 12  and R 13  within —C(═O)NR 12 R 13 , —OC(═O)NR 12 R 13 , —NR 12 R 13 , —NR 14 —(CH 2 ) 1-6 —C(═O)NR 12 R 13 , 
         —NR 14 C(═O)—NR 12 R 13 , or —S(═O) 2 NR 12 R 13  together with the nitrogen atom to which they are attached form a ring and mean —(CH 2 ) 3-6 —; —(CH 2 ) 2 —O—(CH 2 ) 2 —; or —(CH 2 ) 2 —NR B —(CH 2 ) 2 —, wherein R B  means —H or —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br and —I; 
         or a physiologically acceptable salt thereof. 
       
     
     
         2 . The compound according to  claim 1 , wherein R 6 , R 7 , R 8 , R 9 , R 10 , and R 11  independently of one another mean —H, —F, —OH, or —C 1 -C 6 -alkyl; or R 6  and R 7  together mean ═O. 
     
     
         3 . The compound according to  claim 1 , wherein
 R 1  means —H; and R 2  means —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;   R 1  means —CH 3 ; and R 2  means —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;   R 1  means —H or —CH 3 ; and R 2  means a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted;   R 1  means —H or —CH 3 ; and R 2  means a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted; wherein said 3-12-membered cycloalkyl moiety is connected through —CH 2 —, unsubstituted; or   R 1  and R 2  together with the nitrogen atom to which they are attached form a ring and mean —(CH 2 ) 3-6 —.   
     
     
         4 . The compound according to  claim 1 , wherein R 3  means —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted. 
     
     
         5 . The compound according to  claim 1 , wherein R 3  means a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted, optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted. 
     
     
         6 . The compound according to  claim 1 , wherein R 3  means a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted. 
     
     
         7 . The compound according to  claim 1 , wherein R 3  means
 -phenyl, unsubstituted, mono-, di- or trisubstituted with —F, —Cl, —Br, —C 1 -C 4 -alkyl, —CF 3 ,   —CHF 2 , —CH 2 F, —CN, —OH, —OC 1 -C 4 -alkyl, —OCF 3  or —OCH 2 OCH 3 ; or   -pyridinyl or thienyl, in each case unsubstituted, mono-, di- or trisubstituted with —F, —Cl,   —Br, —C 1 -C 4 -alkyl, —CF 3 , —CHF 2 , —CH 2 F, —CN, —OH, —OC 1 -C 4 -alkyl, —OCF 3  or —OCH 2 OCH 3 .   
     
     
         8 . The compound according to according to  claim 1 , wherein R 4  means
 H;   —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted;   a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein the 3-12-membered cycloalkyl moiety is connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or   a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is connected through   —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted.   
     
     
         9 . The compound according to according to  claim 1 , wherein R 4  means
 a 6-14-membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6-14-membered aryl moiety is connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or   a 5-14-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5-14-membered heteroaryl moiety is connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted.   
     
     
         10 . The compound according to  claim 1 , wherein, R 5  means —H. 
     
     
         11 . The compound according to  claim 1 , wherein R 5  means —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —O—C 1 -C 4 -alkyl,
 —O—(CH 2 CH 2 —O) 1-30 —H, —O—(CH 2 CH 2 —O) 1-30 —CH 3 , —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NHC 1 -C 4 -alkyl, —C(═O)N(C 1 -C 4 -alkyl) 2 , —S(═O)C 1 -C 4 -alkyl and —S(═O) 2 C 1 -C 4 -alkyl. 
 
     
     
         12 . The compound according to  claim 1 , wherein R 5  means —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, monosubstituted with a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C═O—. 
     
     
         13 . The compound according to  claim 1 , wherein R 5  means a 3-12-membered cycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —C 1 -C 4 -alkyl, —O—C 1 -C 4 -alkyl, —C 1 -C 4 -alkyl-OH, —O—(CH 2 CH 2 —O) 1-30 —H, —O—(CH 2 CH 2 —O) 1-30 —CH 3 , —C(═O)OH, —C(═O)C 1 -C 4 -alkyl,
 —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NHC 1 -C 4 -alkyl, —C(═O)N(C 1 -C 4 -alkyl) 2 , —NH 2 , —NHC 1 -C 4 -alkyl, N(C 1 -C 4 -alkyl) 2 , —NHC(═O)—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl)C(═O)C 1 -C 4 -alkyl, 
 —S(═O)C 1 -C 4 -alkyl and —S(═O) 2 C 1 -C 4 -alkyl; wherein said 3-12-membered cycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted. 
 
     
     
         14 . The compound according to  claim 1 , wherein R 5  means a 3-12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, —C 1 -C 4 -alkyl,
 —O—C 1 -C 4 -alkyl, —C 1 -C 4 -alkyl-OH, —O—(CH 2 CH 2 —O) 1-30 —H, —O—(CH 2 CH 2 —O) 1-30 —CH 3 , —C(═O)OH, —C(═O)C 1 -C 4 -alkyl, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NHC 1 -C 4 -alkyl, —C(═O)N(C 1 -C 4 -alkyl) 2 , —NH 2 , —NHC 1 -C 4 -alkyl, N(C 1 -C 4 -alkyl) 2 , —NHC(═O)—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl)C(═O)C 1 -C 4 -alkyl, —S(═O)C 1 -C 4 -alkyl and —S(═O) 2 C 1 -C 4 -alkyl; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted. 
 
     
     
         15 . The compound according to  claim 1 , wherein R 5  means -phenyl, unsubstituted, mono- or polysubstituted; wherein said phenyl is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said phenyl is optionally connected through —C(═O)—, —C(═O)O—, —C(═O)O—CH 2 —, or —S(═O) 2 —. 
     
     
         16 . The compound according to  claim 1 , wherein R 5  means a bicyclic 9-10-membered heteroaryl moiety, unsubstituted, mono- or polysubstituted. 
     
     
         17 . The compound according to  claim 1 , wherein R 5  has a meaning selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         18 . The compound according to  claim 1 , wherein
 R 1  means —H or —C 3 ;   R 2  means —C 1 -C 6 -alkyl, linear or branched, saturated, unsubstituted; -cyclopropyl; or -cyclopropylmethylene;   or R 1  and R 2  together with the nitrogen atom to which they are attached form a ring and mean -azetidine or -pyrrolidine;   R 3  means -phenyl, -thienyl or -pyridinyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —CN, —C 1 -C 4 -alkyl, —CH 3 , —CH 2 CH 3 , —CH 2 F, —CHF 2 , —CF 3 , —OCF 3 , —OH, —O—C 1 -C 4 -alkyl, —OCH 3 , —C(═O)NH 2 , C(═O)NHCH 3 , —C(═O)N(CH 3 ) 2 , —NH 2 ,   —NHCH 3 , —N(CH 3 ) 2 , —NHC(═O)CH 3 , —CH 2 OH, SOCH 3  and SO 2 CH 3 ; or   R 4  means
 —H; 
 —C 1 -C 6 -alkyl, linear or branched, saturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, ═O, —S(═O) 2 —C 1 -C 4 -alkyl and —O—C 1 -C 4 -alkyl; 
 3-6-membered cycloalkyl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, and —O—C 1 -C 4 -alkyl, wherein said 3-6-membered cycloalkyl is connected through —C 1 -C 6 -alkylene; 
 3-12-membered heterocycloalkyl, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, —OH, and —O—C 1 -C 4 -alkyl; wherein said 3-12-membered heterocycloalkyl is optionally connected through —C 1 -C 6 -alkylene-, unsubstituted or substituted with ═O; 
 6-14-membered aryl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, 
 —Br, —I, —CN, —OH, and —O—C 1 -C 4 -alkyl; wherein said 6-14-membered aryl is optionally connected through —C 1 -C 6 -alkylene- or —S(═O) 2 —; 
   R 5  means
 —H; 
 —C 1 -C 6 -alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, ═O, —OH, —O—C 1 -C 4 -alkyl, —O—(CH 2 CH 2 —O) 1-30 —H, —O—(CH 2 CH 2 —O) 1-30 —CH 3 , —C(═O)OH, —C(═O)C 1 -C 4 -alkyl, —C(═O)OC 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NHC 1 -C 4 -alkyl, —C(═O)N(C 1 -C 4 -alkyl) 2 , —(C═O)-heterocycloalkyl, —S(═O)C 1 -C 4 -alkyl, —S(═O) 2 C 1 -C 4 -alkyl, —NH 2 , —NH—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl) 2 , —NHC(═O)—C 1 -C 4 -alkyl, —NH—S(═O) 2 C 1 -C 4 -alkyl; 
 3-12-membered heterocycloalkyl, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of —F, —Cl, —Br, —I, —CN, ═O, —OH, —C 1 -C 4 -alkyl, —NH 2 , —NH—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl) 2 , —NHC(═O)—C 1 -C 4 -alkyl, —NHS(═O) 2 —C 1 -C 4 -alkyl, —O—C 1 -C 4 -alkyl, —O—(CH 2 CH 2 —O) 1-30 —H, —O—(CH 2 CH 2 —O) 1-30 —CH 3 , —C(═O)OH, —C(═O)OC 1 -C 4 -alkyl, —C(═O)C 1 -C 4 -alkyl, —C(═O)NH 2 , —C(═O)NHC 1 -C 4 -alkyl, —C(═O)N(C 1 -C 4 -alkyl) 2 , —S(═O)C 1 -C 4 -alkyl, —S(═O) 2 C 1 -C 4 -alkyl, -phenyl, —C(═O)-phenyl, —C(═O)-pyridyl, 
   -pyridyl, -pyrimidinyl, and -pyridazinyl; wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C 1 -C 6 -alkylene-, linear or branched, saturated or unsaturated, unsubstituted; or wherein said 3-12-membered heterocycloalkyl moiety is optionally connected through —C═O— or —CH 2 —C═O—;
 -1,2-benzodioxole, -pyrazinyl, -pyridazinyl, -pyridinyl, -pyrimidinyl, -thienyl, 
 -imidazolyl, 
 -benzimidazolyl, -thiazolyl, -1,3,4-thiadiazolyl, -benzothiazolyl, -oxazolyl, 
 -benzoxazolyl, -pyrazolyl, 
 -quinolinyl, -isoquinolinyl, -quinazolinyl, -indolyl, -indolinyl, 
 -benzo[c][1,2,5]oxadiazolyl, 
 -imidazo[1,2-a]pyrazinyl, or -1H-pyrrolo[2,3-b]pyridinyl, in each case unsubstituted, mono- or polysubstituted; 
   and   R 6 , R 7 , R 8 , R 9 , R 10 , and R 11  mean —H; or R 6  and R 7  together mean ═O and R 8 , R 9 , R 10 , and R 11  mean —H.   
     
     
         19 . The compound according to  claim 1   claim 1 , which is selected from the group consisting of
 2-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)acetamide   2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro-[3.4]-octan-6-one   5-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxy-pyrimidine-2-carbonitrile   5-(cyclobutylmethyl)-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   2-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)acetamide   5-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxypyrimidine-2-carbonitrile   2-(dimethylamino)-7-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   7-(6-(azetidin-1-yl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   5-(2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methylpicolino-nitrile   5-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methyl-picolinonitrile   6-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-5-methyl-nicotinonitrile   2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]-octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-7-(4-methyl-6-morpholinopyridin-3-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-7-(6-(2-hydroxypropan-2-yl)-4-methylpyridin-3-yl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   2-(dimethylamino)-7-(4-(2-hydroxypropan-2-yl)-2-methylphenyl)-2-phenyl-5,7-diazaspiro[3.4]-octan-6-one   7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluorophenyl)-5,7-diazaspiro-[3.4]octan-6-one   2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluoro-phenyl)-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-7-(2-morpholinopyrimidin-5-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-5-((1-fluorocyclopropyl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-2-(3-fluorophenyl)-5-((1-hydroxycyclobutyl)methyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-(2-hydroxypropan-2-yl)phenyl)-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-(methylsulfonyl)ethyl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-7-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-7-(6-cyclopropylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   7-(6-cyclopropyl-4-methylpyridin-3-yl)-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   7-(6-cyclopropyl-4-methylpyridin-3-yl)-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-methoxy-2-methylpropyl)-5,7-diazaspiro[3.4]octan-6-one   2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-[5-(trifluoromethyl)pyridin-3-yl]-5,7-diazaspiro[3.4]octan-6-one   5-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile   2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-morpholinobenzyl)-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[(1-hydroxycyclobutyl)methyl]-5,7-diazaspiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diaza-spiro[3.4]octan-6-one   3-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)propanenitrile   3-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-propanenitrile   5-(cyclopropylmethyl)-2-(dimethylamino)-7-[(1-hydroxycyclobutyl)methyl]-2-phenyl-5,7-diaza-spiro[3.4]octan-6-one   5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[2-(oxetan-3-yl)ethyl]-5,7-diaza-spiro[3.4]octan-6-one   cis-2-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)acetamide   cis-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   cis-5-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxy-pyrimidine-2-carbonitrile   trans-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   trans-5-(2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxy-pyrimidine-2-carbonitrile   cis-5-(cyclobutylmethyl)-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxo-ethyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   trans-5-(cyclobutylmethyl)-2-(dimethylamino)-7-(2-(1,1-dioxidothiomorpholino)-2-oxoethyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   cis-2-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl-)acetamide   trans-2-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]-octan-7-yl)-acetamide   cis-5-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl)-4-methoxypyrimidine-2-carbonitrile   trans-5-(5-(cyclobutylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]-octan-7-yl)-4-methoxypyrimidine-2-carbonitrile   cis-2-(dimethylamino)-7-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   cis-7-(6-(azetidin-1-yl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   cis-5-(2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methyl-picolinonitrile   cis-5-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-4-methylpicolinonitrile   cis-6-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)-5-methylnicotinonitrile   cis-2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]-octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-7-(4-methyl-6-morpholinopyridin-3-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-7-(6-(2-hydroxypropan-2-yl)-4-methylpyridin-3-yl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   cis-2-(dimethylamino)-7-(4-(2-hydroxypropan-2-yl)-2-methylphenyl)-2-phenyl-5,7-diazaspiro-[3.4]octan-6-one   cis-7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluorophenyl)-5,7-diaza-spiro[3.4]octan-6-one   cis-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-7-(6-(difluoromethyl)-4-methylpyridin-3-yl)-2-(dimethylamino)-2-(3-fluorophenyl)-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-7-(2-morpholinopyrimidin-5-yl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-5-((1-fluorocyclopropyl)methyl)-2-(3-fluorophenyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-2-(3-fluorophenyl)-5-((1-hydroxycyclobutyl)methyl)-7-(5-(trifluoromethoxy)-pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-(2-hydroxypropan-2-yl)-phenyl)-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-(methylsulfonyl)ethyl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(5-(trifluoromethoxy)pyridin-2-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-7-((3-fluorooxetan-3-yl)methyl)-2-(3-fluorophenyl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-7-(6-cyclopropylpyridin-3-yl)-2-(dimethylamino)-2-phenyl-5,7-diaza-spiro[3.4]octan-6-one   cis-7-(6-cyclopropyl-4-methylpyridin-3-yl)-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   cis-7-(6-cyclopropyl-4-methylpyridin-3-yl)-2-(dimethylamino)-5-((3-fluorooxetan-3-yl)methyl)-2-phenyl-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-(2-methoxy-2-methylpropyl)-5,7-diazaspiro[3.4]octan-6-one   cis-2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-[5-(trifluoromethyl)pyridin-3-yl]-5,7-diazaspiro[3.4]octan-6-one   cis-5-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile   cis-2-(dimethylamino)-2-(3-fluorophenyl)-7-(4-morpholinobenzyl)-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[(1-hydroxycyclobutyl)methyl]-5,7-diazaspiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-phenyl-7-(2-pyridin-4-ylpyrimidin-5-yl)-5,7-diazaspiro[3.4]octan-6-one   cis-3-(5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-6-oxo-5,7-diazaspiro[3.4]octan-7-yl)propanenitrile   cis-3-[5-(cyclopropylmethyl)-2-(dimethylamino)-6-oxo-2-phenyl-5,7-diazaspiro[3.4]octan-7-yl]-propanenitrile   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-7-[(1-hydroxycyclobutyl)methyl]-2-phenyl-5,7-diaza-spiro[3.4]octan-6-one   cis-5-(cyclopropylmethyl)-2-(dimethylamino)-2-(3-fluorophenyl)-7-[2-(oxetan-3-yl)ethyl]-5,7-diaza-spiro[3.4]octan-6-one   and the physiologically acceptable salts thereof.   
     
     
         20 . A medicament comprising a compound according to  claim 1 . 
     
     
         21 . A method of treating pain in a subject in need thereof, said method comprising administering to said subject an effective amount therefor of at least one compound according to  claim 1 .