Composition

Abstract

The present invention relates to compositions for use and formulation as weight management products and in particular fermented dairy foodstuffs. The compositions generally comprise two or more of the following components: a) a microbiome modifying component; b) a satiety modifying component; and c) a metabolic modifying component and at least one of the following: d) Streptococcus thermophilus CBS 139100 and Lactobacillus delbrueckii subsp. bulgaricus CBS 139099 microbial strains or mutant strains or fragments or fractions thereof; e) a combination of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus microbial strains which together, or individually, are capable of secreting polysaccharides having high levels of galactosamine and no or low levels of rhamnose and glucuronic acid when grown on a dairy substrate; or f) polysaccharides formed of: i) 15-25% galactosamine; ii) 45-60% galactose; and iii) 20-30% glucose. The compositions may also be useful in the management or treatment of obesity, elevated cholesterol, diabetes, hypertension or heart disease.

1 . A composition comprising two or more of the following components:
 a) a microbiome modifying component;   b) a satiety modifying component; and   c) a metabolic modifying component,   and at least one of following:   d)  Streptococcus thermophilus  CBS 139100 and  Lactobacillus delbrueckii  subsp.  bulgaricus  CBS 139099 microbial strains or fragments or fractions thereof;   e) a combination of  Streptococcus thermophilus  and  Lactobacillus delbrueckii  subsp.  bulgaricus  microbial strains which together, are capable of secreting polysaccharides having high levels of galactosamine and no or low levels of rhamnose and glucuronic acid when grown on a dairy substrate; or   f) polysaccharides formed of:
 i) 15-25% galactosamine; 
 ii) 45-60% galactose; and 
 iii) 20-30% glucose. 
   
     
     
         2 . The composition of  claim 1 , wherein the composition comprises polysaccharides having high levels of galactosamine and no or low levels of rhamnose and glucuronic acid. 
     
     
         3 . The composition of  claim 1 , wherein the polysaccharides comprise 45-60% galactose, 20-30% glucose and 15-25% galactosamine, based on the total weight of secreted exopolysaccharides. 
     
     
         4 . The composition of  claim 1 , wherein the composition comprises— Streptococcus thermophilus  CBS 139100 and  Lactobacillus delbrueckii  subsp.  bulgaricus  CBS 139099 microbial strains. 
     
     
         5 . The composition of  claim 1 , wherein the composition comprises f) and further comprises  Streptococcus thermophilus  and  Lactobacillus delbrueckii  subsp.  bulgaricus  microbial strains. 
     
     
         6 . (canceled) 
     
     
         7 . (canceled) 
     
     
         8 . (canceled) 
     
     
         9 . The composition of  claim 1 , wherein the microbiome modifying component comprises a growth medium, a selective microbial growth inhibitor, a micro-biocidal compound or a combination thereof. 
     
     
         10 . The composition of  claim 8 , wherein the growth medium comprises a prebiotic. 
     
     
         11 . (canceled) 
     
     
         12 . (canceled) 
     
     
         13 . The composition of  claim 1 , wherein the microbiome modifying component comprises a prebiotic; the satiety modifying component comprises dietary fibre and the metabolic modifying component comprises chromium. 
     
     
         14 . The composition of  claim 13 , wherein the dietary fibre comprises glucomannan and/or a prebiotic comprising one or more selected from: inulin, fructooligosaccharides (FOS), galactooligosaccharides (GOS), α-gluco-oligosaccharides, a low gas producing prebiotic and combinations thereof. 
     
     
         15 . The composition of  claim 13 , wherein the composition comprises the dietary fibre in the range of 0.5 to 15 g. 
     
     
         16 . The composition of  claim 13 , wherein the composition comprises chromium in the range of 50 to 1000 μg. 
     
     
         17 . The composition of  claim 13 , wherein the composition comprises a prebiotic in the range of 3 to 30 g. 
     
     
         18 . A composition comprising a combination of:
 a) glucomannan and chromium;   b) glucomannan, FOS and chromium;   c) glucomannan and FOS; or   d) glucomannan and a low gas producing prebiotic.   
     
     
         19 . The composition of  claim 18 , wherein the composition is grown on a dairy substrate, is formed as part of a dairy substrate or product or is used as a feedstock, ingredient or additive for use with a fermented or fermentable dairy foodstuff. 
     
     
         20 . The composition of  claim 19 , wherein the fermented or fermentable dairy foodstuff is selected from one or more of the following: yoghurt, cheese, crème fraiche, sour cream, buttermilk, kefir, acidophilus milk, koumiss, filmjölk and viili. 
     
     
         21 . The composition of  claim 19 , wherein the composition further comprises one or more ingredients selected from: sweeteners, stabilisers, acidity regulators, water, flavourings, fats, emulsifiers, plant and/or vegetable extracts, vitamins, minerals, phytochemicals, antioxidants, and combinations thereof. 
     
     
         22 . The composition of  claim 18 , wherein the composition comprises:
 a) 50 to 90% fermented or fermentable dairy food stuff comprising and/or fermented using  Streptococcus thermophilus  CBS 139100 and  Lactobacillus delbrueckii  subsp.  bulgaricus  CBS 139099;   b) 1 to 10% sweetener;   c) 5 to 20% GOS;   d) up to 1.5% glucomannan;   e) up to 0.010% chromium chloride; and optionally   f) 5 to 30% fruit preparation.   
     
     
         23 . A method for treatment or management of weight, elevated cholesterol, diabetes, hypertension or heart disease in a subject comprising providing the subject with the composition of  claim 1 . 
     
     
         24 . (canceled) 
     
     
         25 . (canceled) 
     
     
         26 . (canceled) 
     
     
         27 . (canceled) 
     
     
         28 . (canceled) 
     
     
         29 . (canceled) 
     
     
         30 . (canceled) 
     
     
         31 . (canceled) 
     
     
         32 . The method of  claim 23  wherein the method provides for the management of weight. 
     
     
         33 . The method of  claim 23  wherein the method provides for the treatment of diabetes.