Ostrich antibody for bacterial infectious diseases

Abstract

The present invention provides an ostrich antibody-containing composition for treating a bacterial infectious disease, and a method for treating a bacterial infectious disease by using the ostrich antibody. The present invention further provides a method for producing this ostrich antibody. The infectious disease can be a gastrointestinal infection. The ostrich antibody can be produced by using a component derived from a bacterium as an immunogen. The bacterium can be Clostridium difficile, Vibrio cholera, Staphylococcus aureus, or the like. Further, the bacterium can be a drug-resistant bacterium.

1 . A method of treating an infectious disease of a gastrointestinal tract infectious bacterium, comprising administering ostrich antibodies to a subject, wherein immunogens of the antibodies are components derived from the bacterium. 
     
     
         2 . The method of  claim 1 , wherein the bacterium is selected from the group consisting of  Clostridium difficile, Vibrio cholera, Staohylococcus aureus, Pseudomonas aeruginosa, Enterobacteriaceae, Enterococcus faecium, Helicobacter pylori, Campylobacter, Salmonella,  and  Shigella.    
     
     
         3 . The method of  claim 1 , wherein the infectious disease is a gastrointestinal tract infectious disease. 
     
     
         4 . The method of  claim 1 , wherein the infectious disease includes an infectious disease in at least one location of a stomach, a duodenum, a small intestine, a large intestine, a rectum, and an anus. 
     
     
         5 . The method of  claim 1 , wherein the components derived from the bacterium include a microbial cell, a homogenate, a toxin, an enzyme, a polysaccharide, a pigment, a cell wall, a cytoplasm, a spore, a flagellum, a fimbria of the bacterium, or a part thereof, or any combination thereof. 
     
     
         6 . The method of  claim 1 , wherein the bacterium includes  Clostridium difficile.    
     
     
         7 . The method of  claim 6 , wherein the immunogens include at least one of  Clostridium difficile  toxin A and toxin B. 
     
     
         8 . The method of  claim 1 , wherein the bacterium includes  Vibrio cholera.    
     
     
         9 . The method of  claim 8 , wherein the immunogens include  Vibrio cholera  toxin. 
     
     
         10 . The method of  claim 1 , wherein the bacterium includes  Staphylococcus aureus.    
     
     
         11 . The method of  claim 10 , wherein the immunogens include a homogenate of  Staphylococcus aureus.    
     
     
         12 . The method of  claim 1 , wherein the infectious disease is due to an agent-resistant bacterium of the bacterium. 
     
     
         13 . The method of  claim 12 , wherein the components derived from the bacterium include a homogenate of the bacterium. 
     
     
         14 . The method of  claim 8 ,
 wherein the components derived from the bacterium include a homogenate of the bacterium; and   wherein the bacterium includes methicillin-resistant  Staphylococcus aureus.      
     
     
         15 . The method of  claim 1 , wherein the ostrich antibodies are administered as a pharmaceutical composition. 
     
     
         16 . The method of  claim 15 , wherein the ostrich antibodies are administered as a pharmaceutical composition for oral administration. 
     
     
         17 . The method of  claim 1 , wherein the ostrich antibodies are administered as a food composition. 
     
     
         18 . The method of  claim 1 , wherein the ostrich antibodies are administered as a candy