Edds chelated nanoceria with catalase-like activity

Abstract

A process for making nanoparticles of biocompatible materials, wherein an aqueous reaction mixture comprising cerous ion, ethylenediaminedisuccinic acid, an oxidant, water, and optionally citric acid, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of cerium oxide nanoparticles. Also, biocompatibe nanoparticles comprised of cerium oxide, ethyenediaminedisuccinic acid, and optionally citric acid. An increase in catalase-like enzyme activity is demonstrated by cerium oxide nanoparticles prepared with citric acid and ethylenediaminedisuccinic acid.

1 . A pharmaceutical composition comprising cerium oxide nanoparticies and ethylenediaminedisuccinic acid. 
     
     
         2 . A method of prophylactically treating a patient to prevent an oxidative stress related disease or an oxidative stress related event, comprising: administering a pharmaceutical composition comprising an effective amount of cerium oxide nanoparticles and ethylenediaminedisuccinic acid. 
     
     
         3 . A method of treating a symptom of an oxidative stress related disease or an oxidative stress related event in a patient, comprising: administering a pharmaceutical composition comprising an effective amount of cerium oxide nanoparticles and ethylenediaminedisuccinic acid.