Stabilized aqueous composition comprising chondroitin sulfate and hyaluronic acid

Abstract

The present invention relates to an aqueous composition which comprises chondroitin sulfate, hyaluronic acid, and a pharmaceutically acceptable carrier, and which can be stored at room temperature. The present invention also relates to an aqueous composition which comprises chondroitin sulfate, hyaluronic acid, sorbitol, and a pharmaceutical acceptable carrier.

1 - 20 . (canceled) 
     
     
         21 . A method for stabilizing an aqueous composition, wherein the method comprising adding sorbitol in an aqueous composition which comprises 20 to 60 mg/mL of chondroitin sulfate, 10 to 40 mg/mL of hyaluronic acid, and a pharmaceutically acceptable carrier, thereby stabilizing the aqueous composition at room temperature. 
     
     
         22 . A method of manufacturing an ophthalmic surgical aid, comprising including an aqueous composition in an ophthalmic surgical aid employed in an ophthalmic surgery for treating an ocular disease, wherein the aqueous composition comprises chondroitin sulfate, hyaluronic acid, sorbitol, and a pharmaceutically acceptable carrier. 
     
     
         23 . The method of  claim 22 , wherein the aqueous composition in the ophthalmic surgical aid is stored at room temperature. 
     
     
         24 . The method of  claim 21 , wherein the sorbitol is D-sorbitol. 
     
     
         25 . The method of  claim 21 , wherein the composition has a viscosity of 20,000 to 120,000 mPa·s at 25° C. and at a shear rate of 2 s −1 . 
     
     
         26 . The method of  claim 21 , wherein the sorbitol concentration in the composition is 0.1 mg/mL or higher, 0.5 mg/mL or higher, 1 mg/mL or higher, 2 mg/mL or higher, 100 mg/mL or lower, 80 mg/mL or lower, 50 mg/mL or lower, 20 mg/mL or lower, 10 mg/mL or lower, 0.5 to 100 mg/mL, 1 to 80 mg/mL, 2 to 40 mg/mL, 2.5 to 20 mg/mL, or 5 to 10 mg/mL. 
     
     
         27 . The method of  claim 21 , wherein the sorbitol concentration in the composition is 1 to 80 mg/mL.