US2020352971A1PendingUtilityA1

Injectable antibiotic formulations and use thereof

70
Assignee: PIEDMONT ANIMAL HEALTH INCPriority: Jun 10, 2015Filed: Jul 23, 2020Published: Nov 12, 2020
Est. expiryJun 10, 2035(~8.9 yrs left)· nominal 20-yr term from priority
Inventors:Neil E. PaulsenGail L. DempseyMichael S. DanielTiffany G. TomlinsonDouglas I. HeplerRaymond Petzold
A61K 31/7052A61K 47/14A61K 9/0019A61K 47/44A61K 45/06Y02A50/30
70
PatentIndex Score
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Claims

Abstract

Provided herein are pharmaceutically acceptable compositions containing macrolide antibiotics, in particular azithromycin. In particular, compositions containing azithromycin with low toxicity, especially for administration to felines, are provided herein.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition, comprising:
 (i) a hydrated macrolide;   (ii) at least one suitable solvent; and   (iii) an excipient.   
     
     
         2 . The composition of  claim 1 , wherein the solvent is triacetin. 
     
     
         3 . The composition of  claim 1 , wherein the macrolide is azithromycin. 
     
     
         4 . The composition of  claim 1 , wherein the solvent is present in an amount of about 38.0% w/w. 
     
     
         5 . The composition of  claim 1 , further comprising a surfactant. 
     
     
         6 . The composition of  claim 5 , wherein the surfactant is castor oil. 
     
     
         7 . The composition of  claim 5 , wherein the castor oil comprises kalliphor HS15. 
     
     
         8 . The composition of  claim 1 , wherein the solvent is caprylic or caprylic/capric triglycerides. 
     
     
         9 . The composition of  claim 8 , wherein the solvent is present in an amount of about 54.0 w/w. 
     
     
         10 . The composition of  claim 1 , wherein azithromycin is present in an amount of about 7.0% w/w. 
     
     
         11 . The composition of  claim 1 , wherein the solvent is triacetin and caprylic, caprylic or capric triglycerides. 
     
     
         12 . The composition of  claim 8 , wherein the triglyceride is a C8 triglyceride. 
     
     
         13 . The composition of  claim 11 , wherein the triglyceride is a C8 triglyceride. 
     
     
         14 . The composition of  claim 1 , wherein the composition is formulated for injection. 
     
     
         15 . A method of treating an infection in a subject weighing less than about 100 pounds, comprising administering an effective amount of a composition of  claim 1 . 
     
     
         16 . The method of  claim 15 , further comprising administering an additional antibiotic in combination with the composition of  claim 1 . 
     
     
         17 . The method of  claim 15 , wherein the subject is a feline. 
     
     
         18 . The method of  claim 15 , wherein the composition is administered by injection. 
     
     
         19 . A composition formulated for injection, comprising about 54.0 w/w caprylic triglycerides; about 38.0% w/w triacetin; KALLIPHOR™ HS15; and about 7.0% w/w azithromycin DH.

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