Filing system and methods for aseptic cartridge and dispenser arrangement

Abstract

A package for use with a beneficial agent delivery device. The package includes at least one filling chamber having a sealed penetrable access region, at least one compartment configured to hold a content, wherein the content includes at least one of a beneficial agent or a constituent of a beneficial agent, and at least one channel connecting the at least one filling chamber in fluid communication with the at least one compartment. At least a portion of the package is resealable to contain the content.

1 .- 20 . (canceled) 
     
     
         21 . A filling system, comprising:
 at least one body for receiving a sealed package, the package comprising at least one filling chamber, at least one channel, and at least one compartment;   at least one piercing element operable to pierce the sealed package at an access region; and   at least one sealing member operable to seal the package.   
     
     
         22 . The filling system of claim  1 , wherein the at least one body comprises a cavity for holding a package, comprising a region for at least one of at least one filling chamber, at least one channel, and at least one compartment. 
     
     
         23 . The filling system of claim  1 , wherein the at least one piercing element is configured to at least one of fill content into the package and remove content from the package. 
     
     
         24 . The filling system of claim  1 , wherein the piercing element pierces the package to access the at least one filling chamber. 
     
     
         25 . The filling system of claim  2 , wherein the cavity and the at least one compartment are congruent. 
     
     
         26 . The filling system of claim  2 , having a controllable pressure therein configured to retain a wall of the package congruently in the cavity. 
     
     
         27 . The filling system of claim  2 , wherein a vacuum force maintains at least a portion of a wall of the compartment congruent with the cavity. 
     
     
         28 . The filling system of claim  1 , wherein a vacuum force enhances a fluid-tight seal between the filling system and the access region. 
     
     
         29 . The filling system of claim  1 , wherein the at least one sealing member is operable to seal the at least one channel by at least one of heat sealing, pinching, linear actuation, and rotational actuation. 
     
     
         30 . The filling system of claim  1 , further comprising a sensor operable to sense a fluid in at least one the at least one channel and the at least one filling chamber. 
     
     
         31 . The filling system of claim  1 , further comprising a valve operable to stop filling of the at least one compartment. 
     
     
         32 . The filling system of claim  1 , further comprising a washing device operable to wash the package. 
     
     
         33 . The filling system of claim  1 , wherein the at least one sealing member is configured to seal the package while the access region is being accessed. 
     
     
         34 . The filling system of claim  1 , further comprising a plurality of piercing elements. 
     
     
         35 . The filling system of claim  1 , further comprising a plurality of sealing members. 
     
     
         36 . The filling system of claim  1 , wherein the at least one piercing element and the at least one sealing member are configured to pierce a plurality of access regions and perform plurality of seals in sequence. 
     
     
         37 . The filling system of claim  16 , wherein the sequence comprises at least one of filling and removing at least one of air, a content, a beneficial agent, a decontamination agent, a disinfecting agent, a cleaning agent, a sterilization agent, a flushing fluid, a fluid, a liquid, a gas, a suspension, a gel, a paste, a powder, pellet, granules, a dry substance, a drying agent, vapor, moisture, and a constituent. 
     
     
         38 . The filling system of claim  1 , further comprising inspecting content removed from the package. 
     
     
         39 . The filling system of claim  1 , further comprising inspecting content retained in the package by analyzing at least one of chemical composition, chemical concentrations, presence and concentration of particles, presence and concentration of particles larger than 50 microns, color, optical absorbance, optical reflectance, optical scattering, optical interference, pH, oxidation, conductivity, total organic carbons, and turbidity of the content. 
     
     
         40 . The filling system of claim  1 , further comprising an instrument for substantially emptying the at least one filling chamber by one of collapsing the at least one filling chamber and removing content with the at least one piercing element. 
     
     
         41 . The filling system of claim  20 , wherein the at least one filling chamber is sealed from the at least one compartment prior to emptying the at least one filling chamber. 
     
     
         42 . The filling system of claim  20 , wherein the at least one filling chamber is sealed from the at least one compartment after emptying the at least one filling chamber. 
     
     
         43 . The filling system of claim  1 , further comprising a fluidic system comprising at least one reservoir for at least one of receiving content from and delivering content to the package. 
     
     
         44 . The filling system of  claim 23 , wherein the fluidic system comprises the at least one piercing element. 
     
     
         45 . The filling system of  claim 24 , wherein the at least one piercing element is in fluid communication with the at least one reservoir via a tube. 
     
     
         46 . The filling system of  claim 23 , wherein at least a portion of the fluidic system is disposable. 
     
     
         47 . The filling system of claim  1 , further comprising a preparation system for preparing the at least one piercing element and the access region for access by the at least one piercing element. 
     
     
         48 . The filling system of the  claim 27 , wherein the preparation system comprising at least one of wiping, radiating, UV illuminating, IR radiating, flushing, purging, puffing, and dispensing at least one of a cleaning agent, decontamination agent, sterilization agent, hydrogen-peroxide vapor, ethylene-oxide, sterile water, sterile air, water vapor, gas, and nitrogen gas to at least one of the at least one piercing element and the access region.