Compositions of herbal formulations and uses thereof

Abstract

Disclosed herein are herbal formulations for relief from symptoms of skin disease. The formulations can also be combined with an active or inactive pharmaceutical ingredient, and/or a pharmaceutically acceptable excipient.

What is claimed is: 
     
         1 . A composition comprising a mixture of plant extracts, wherein the mixture comprises:
 a) at least one Group I plant extract and at least one Group II plant extract, wherein the at least one Group I plant extract and the at least one Group II plant extract are different;   b) at least one Group I plant extract and at least one Group III plant extract, wherein the at least one Group I plant extract and the at least one Group III plant extract are different;   c) at least one Group I plant extract and at least one Group IV plant extracts, wherein the at least one Group I plant extract and the at least one Group IV plant extract are different;   d) at least one Group II plant extract and at least one Group III plant extracts, wherein the at least one Group II plant extract and the at least one Group III plant extract are different;   e) at least one Group II plant extract and at least one Group IV plant extract, wherein the at least one Group II plant extract and the at least one Group IV plant extract are different;   f) at least one Group III plant extract and at least one Group IV plant extract, wherein the at least one Group III plant extract and the at least one Group IV plant extract are different;   g) at least one Group I plant extract, at least one Group II plant extract, and at least one Group III plant extract, wherein the at least one Group I plant extract, the at least one Group II plant extract, and the at least one Group III plant extract are different;   h) at least one Group I plant extract, at least one Group II plant extract, and at least one Group IV plant extract, wherein the at least one Group I plant extract, the at least one Group II plant extract, and the at least one Group IV plant extract are different;   i) at least one Group I plant extract, at least one Group III plant extract, and at least one Group IV plant extract, wherein the at least one Group I plant extract, the at least one Group III plant extract, and the at least one Group IV plant extract are different; or   j) at least one Group II plant extract, at least one Group III plant extract, and at least one Group IV plant extracts, wherein the at least one Group II plant extract, the at least one Group III plant extract, and the at least one Group IV plant extract are different;   wherein:   Group I comprises a plant extract obtained from a plant selected from the group consisting of:  Althaea officinalis; Ervum lens; Populas alba; Populus tremuloides; Conium maculatium; Sambucus nigra; Hamamelis virginiana;  and  Phytolacca decendra;      Group II comprises a plant extract obtained from a plant selected from the group consisting of:  Conium maculatium; Phytolacca decendra; Pimpinella saxifraga; Rhus toxicodendron;  and  Vincetoxicum officinale;      Group III comprises a plant extract obtained from a plant selected from the group consisting of:  Avena sativa; Aesuculus hippocastanum; Capsella Bursa Pastoris; Hamamelis virginiana; Hydrastis canadensis; Achillea millefolium;  and  Sanguinaria Canadensis;  and   Group IV comprises a plant extract obtained from a plant selected from the group consisting of:  Berberis vulgaris; Matricaria chamomilla; Cochlearia officinalis; Hydrastis canadensis; Nasturtium officinale; Scrophularia nodosa; Smilax medica; Tussilago farfara;  and  Veronica officinalis.      
     
     
         2 . The composition of  claim 1 , wherein the composition comprises at least two herbal extracts each of which is present in the following amount (w/w):  Achillea millefolium  from about 0.01% to about 20%;  Aesuculus hippocastanum  from about 0.01% to about 20%;  Althaea officinalis  from about 0.01% to about 20%;  Avena sativa  from about 0.01% to about 25%;  Berberis vulgaris  from about 0.01% to about 20%;  Capsella Bursa Pastoris  from about 0.01% to about 20%;  Cochlearia officinalis  from about 0.01% to about 20%;  Conium maculatium  from about 0.01% to about 35%;  Ervum lens  from about 0.01% to about 20%;  Hamamelis virginiana  from about 0.01% to about 25%;  Hydrastis canadensis  from about 0.01% to about 20%;  Matricaria chamomilla  from about 0.01% to about 20%;  Nasturtium officinale  from about 0.01% to about 15%;  Phytolacca decendra  from about 0.01% to about 20%;  Pimpinella saxifraga  from about 0.01% to about 20%;  Populas alba  from about 0.01% to about 20%;  Populus tremuloides  from about 0.01% to about 20%;  Rhus toxicodendron  from about 0.01% to about 25%;  Sambucus nigra  from about 0.01% to about 20;  Sanguinaria Canadensis  from about 0.01% to about 20%;  Scrophularia nodosa  from about 0.01% to about 20%;  Smilax medico  from about 0.01% to about 20%;  Tussilago farfara  from about 0.01% to about 15%;  Veronica officinalis  from about 0.01% to about 15%; and  Vincetoxicum officinale  from about 0.01% to about 15%. 
     
     
         3 . The composition of  claim 1 , comprising an extract selected from the group consisting of:
 i)  Althaea officinalis  from about 1% to about 15%; or from about 1% to about 10%; or from about 1% to about 8%; or from about 1.5% to about 7%; or from about 1.5% to about 5%;   ii)  Ervum lens  from about 1% to about 17%; or from about 1% to about 15%; or from about 3% to about 12%; or from about 3% to about 10%;   iii)  Populas alba  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 4% to about 10%;   iv)  Populus tremuloides  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 4% to about 10%;   v)  Conium maculatium  from about 1% to about 30%; or from about 1% to about 25%; or or from about 3.5% to about 23%;   vi) S ambucus nigra  from about 1% to about 15%; or from about 1% to about 10%; or from about 1% to about 8%; or from about 1.5% to about 7%; or from about 1.5% to about 6%;   vii)  Hamamelis virginiana  from about 1% to about 25%; or from about 3% to about 20%; or from about 5% to about 17%; or from about 5% to about 15%; and   viii)  Phytolacca decendra  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 3.5% to about 10%.   
     
     
         4 . The composition of  claim 1 , comprising an extract selected from the group consisting of:
 i)  Conium maculatium  from about 1% to about 30%; or from about 1% to about 25%; or or from about 3.5% to about 23%;   ii)  Phytolacca decendra  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 3.5% to about 10%;   iii)  Pimpinella saxifraga  from about 0% to about 12%; or from about 0% to about 10%; or from about 0.1% to about 8%; or from about 0.5% to about 5%;   iv)  Rhus toxicodendron  from about 1% to about 25%; or from about 3% to about 20%; or from about 5% to about 20%; or from about 7% to about 20%; and   v)  Vincetoxicum officinale  from about 0% to about 12%; or from about 0% to about 10%; or from about 0.1% to about 8%; or from about 0.1% to about 5%.   
     
     
         5 . The composition of  claim 1 , comprising an extract selected from the group consisting of:
 i)  Avena sativa  from about 1% to about 25%; or from about 3% to about 20%; or from about 5% to about 17%; or from about 5% to about 15%;   ii)  Aesuculus hippocastanum  from about 1% to about 15%; or from about 1% to about 10%; or from about 1% to about 8%; or from about 1.5% to about 7%; or from about 2% to about 6%;   iii)  Capsella Bursa Pastoris  from about 1% to about 17%; or from about 1% to about 15%; or from about 1.5% to about 12%; or from about 1.5% to about 10%;   iv)  Hamamelis virginiana  from about 1% to about 25%; or from about 3% to about 20%; or from about 5% to about 17%; or from about 5% to about 15%;   v)  Hydrastis canadensis  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 3.5% to about 10%.   vi)  Achillea millefolium  from about 1% to about 15%; or from about 1% to about 10%; or from about 1% to about 8%; or from about 1.5% to about 7%; or from about 2% to about 6%; and   vii)  Sanguinaria Canadensis  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 4% to about 10.   
     
     
         6 . The composition of  claim 1 , comprising an extract selected from the group consisting of:
 i)  Berberis vulgaris  from about 1% to about 17%; or from about 1% to about 15%; or from about 3% to about 12%; or from about 3% to about 10%;   ii)  Matricaria chamomilla  from about 1% to about 17%; or from about 1% to about 15%; or from about 1.5% to about 12%; or from about 1.5% to about 10%;   iii)  Cochlearia officinalis  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 4% to about 10%;   iv)  Hydrastis canadensis  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 3.5% to about 10%.   v)  Nasturtium officinale  from about 0% to about 12%; or from about 0% to about 10%; or from about 0.1% to about 8%; or from about 0.1% to about 5%;   vi)  Scrophularia nodosa  from about 1% to about 17%; or from about 3% to about 15%; or from about 3% to about 12%; or from about 4% to about 10%;   vii)  Smilax medica  from about 1% to about 15%; or from about 1% to about 10%; or from about 1% to about 8%; or from about 1.5% to about 7%; or from about 2% to about 6.5%;   viii)  Tussilago farfara  from about 0% to about 12%; or from about 0% to about 10%; or from about 0.1% to about 8%; or from about 0.1% to about 5%; and   ix)  Veronica officinalis  from about 0% to about 12%; or from about 0% to about 10%; or from about 0.1% to about 8%; or from about 0.1% to about 5%.   
     
     
         7 . The composition of  claim 1 , further comprising a physiologically acceptable carrier, diluent, or excipient. 
     
     
         8 . The composition of  claim 1 , wherein the composition is formulated for topical application. 
     
     
         9 . The composition of  claim 1 , wherein the composition is an aqueous solution. 
     
     
         10 . A method of reducing symptoms associated with a skin condition in a subject, comprising identifying the subject in need thereof and administering to the subject an effective amount of the composition of  claim 1 . 
     
     
         11 . The method of  claim 10 , wherein the skin condition is associated with acne vulgaris, psoriasis, eczema, or atopic dermatitis. 
     
     
         12 . The method of  claim 10 , wherein the skin condition is pruritis, erythema, or excoriations.